Excercises to the lecture „Modern Methods in Drug Discovery“ WS16/17 1st Assignment hand in until 06.11.2017 before the lecture first name, family name: Matrikelnummer:

1st Lecture Modern Methods in Drug Discovery WS21/22 2.. Flow of information in a drug

Write down the actual effective substance.Try to find its chemical structure and some information about its molecular

Compare the X-ray structures of tACE with the bound inhibitors lisinopril (1O86.pdb) and captopril (1UZF.pdb). a) Which amino acids form interactions with the zinc ion?. (list

In lectures 3 and 4 guidelines and criteria have been presented, which a chemical compound should possess for good oral bioavailability (molecular weight (MW), number of

The analgesic and anti-inflammatory Ibuprofen faced a series of „me-too“ drugs shortly after its commerical launch, since the corresponding patent claimed the structure

The analgesic and anti-inflammatory Ibuprofen faced a series of „me-too“ drugs shortly after its commerical launch, since the corresponding patent claimed the structure

Retrieve the amino acid sequences (FASTA format) of insulin of the following species from UniProt (www.uniprot.org) and perform a multiple alignment with Clustal Omega

For which other ACE-inhibitors were IC50 values reported in the same publication (and same CHEMBL assay ID: activate “Assay ChEMBLID” by “show columns”) as