Excercises to the lecture „Modern Methods in Drug Discovery“ WS21/22 1st Assignment

In lectures 3 and 4 guidelines and criteria have been presented, which a chemical compound should possess for good oral bioavailability (molecular weight (MW), number of

The analgesic and anti-inflammatory Ibuprofen faced a series of „me-too“ drugs shortly after its commerical launch, since the corresponding patent claimed the structure

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Retrieve the amino acid sequences (FASTA format) of insulin of the following species from UniProt (www.uniprot.org) and perform a multiple alignment with Clustal Omega

Write down the actual effective substance.Try to find its chemical structure and some information about its molecular target e.g.. using PubMed or PubChem http://www.ncbi.nlm.nih.gov

For which other ACE-inhibitors were IC50 values reported in the same publication (and same CHEMBL assay ID: activate “Assay ChEMBLID” by “show columns”) as

The two different rhenium atoms are octahedrally coordinated by oxygen atoms with average Re-O distances of 193.1 and 187.7 pm for the six- and seven-valent rhenium

• 1/6/2011 – The institution in country A makes an award and advises the pensioner of its decision (it also advises the other institutions involved).. • 1/8/2011 –