Reactions 1871, p393 - 4 Sep 2021
Tozinameran S
Leukocytoclastic vasculitis exacerbation: case report
A 46-year-old woman experienced exacerbation of leukocytoclastic vasculitis following Covid-19 vaccination with tozinameran.
The woman, whose past medical history was significant for irritable bowel syndrome, psoriasis, psoriatic arthritis and biopsy- proven leukocytoclastic vasculitis successfully treated with a prednisone taper, presented to hospital with a flare-up of vasculitis.
She denied experiencing any flares for 2 years, until he time she received tozinameran [BNT162b2 mRNA COVID-19 vaccine; route and dosage not stated]. Within 2 days of receiving the vaccine, she noted a mild aggravation of the palpable purpuric papules on her bilateral lower legs. Clinical differential diagnoses included small vessel vasculitis, like IgA vasculitis. The vasculitis gradually stabilised; however, 2 days following the second dose of the vaccine, the vasculitis aggravated again, with remarkable tender palpable purpuric papules distributed bilaterally on her feet, lower legs, upper extremities, abdomen and lower back. No systemic manifestations were evidenced. The exacerbation of leukocytoclastic vasculitis was thus attributed to Covid-19 vaccination with tozinameran.
The woman was treated with unspecified topical steroids and a prednisone taper [outcome not stated].
Cohen SR, et al. Leukocytoclastic vasculitis flare following the COVID-19 vaccine. International Journal of Dermatology 60: 1032-1033, No. 8, Aug 2021. Available from:
URL: http://doi.org/10.1111/ijd.15623 803591830
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Reactions 4 Sep 2021 No. 1871 0114-9954/21/1871-0001/$14.95 Adis © 2021 Springer Nature Switzerland AG. All rights reserved
