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Supplementary Figure 4. Individual Aldosterone, PRA-S and ACE-S levels before and after placebo or eplerenone treatment in CKD patients with T2DM.

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Supplementary Figure 4. Individual Aldosterone, PRA-S and ACE-S levels before and after placebo or eplerenone treatment in CKD patients with T2DM. (PRA-S=

angiotensin based marker for renin, ACE-S= angiotensin based marker for angiotensin- converting enzyme). For better visualization data are plotted logarithmically on the y-axis.

Placebo pre

Placebo post

1 1 0 1 0 0 1 0 0 0

Aldosterone [pmol/L]

Eplerenone pre

Eplerenone post

1 1 0 1 0 0 1 0 0 0 1 0 0 0 0

Aldosterone [pmol/L]

Placebo pre

Placebo post

1 1 0 1 0 0 1 0 0 0 1 0 0 0 0

PRA-S [pmol/L]

Eplerenone pre

Eplerenone post

1 1 0 1 0 0 1 0 0 0 1 0 0 0 0

PRA-S [pmol/L]

Placebo pre

Placebo post

0 .0 0 1 0 .0 1 0 .1 1

ACE-S [(pmol/L/pmol/L)]

Eplerenone pre

Eplerenone post

0 .0 0 1 0 .0 1 0 .1 1

ACE-S [(pmol/L/pmol/L)]

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