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New Anti-Inflammatory Agents

Mosaad S. Mohamed

a

, Aymn E. Rashad

b,

* Mostafa Adbel-Monem

c

, and Samar S. Fatahalla

a

a Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

b Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt.

E-mail: aymnelzeny@yahoo.com

c Pharmacology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

* Author for correspondence and reprint requests

Z. Naturforsch.62 c, 27Ð31 (2007); received May 22/July 3, 2006

The pyrrole derivatives1a,band2a,bwere used as precursors for the preparation ofN- substituted pyrrole derivatives3a,bÐ9a,band pyrrolo[2,3-d]pyrimidines13Ð16. Also, all the newly prepared products were tested for anti-inflammatory activity as analogues to fenam- ates, and some of them revealed moderate anti-inflammatory activity compared to the stand- ard drug indomethacin.

Key words:Pyrrole, Pyrrolo[2,3-d]pyrimidine, Fenamates, Anti-Inflammatory Activity

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