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Phytochemical Studies on Alstonia scholaris Nighat Sultana

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Phytochemical Studies on Alstonia scholaris

Nighat Sultanaaand Muhammad Saleemb

aPharmaceutical Research Center, PCSIR Laboratories Complex, Karachi-75280, Pakistan

bDepartment of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan Reprint requests to Dr. Nighat Sultana. Fax: (92-21) 8141847. E-mail: nighat2001us@hotmail.com Z. Naturforsch.2010,65b,203 – 210; received February 15, 2009

Reinvestigation of the flowers ofAlstonia scholarisof Pakistan origin have resulted in the isolation of three new triterpenoids, two of the ursane type, 3β-acetate-24-nor-urs-4,12-diene ester triterpene (1) and 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene (2), and one of the oleanane type, 3,28-β- diacetoxy-5-olea-triterpene (3), together with two known triterpenes,α-amyrin acetate (4) and ursolic acid (5). This is the first report of the isolation of4and5from the flower part of this species. The structures of1–5were elucidated with the aid of extensive NMR-spectroscopic studies.

Key words: Alstonia scholaris, Apocynaceae, Triterpene, Flowers, Spectroscopic Studies

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