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Figure S1 Flowchart of the cohort process.AP: acute pancreatitis; MAP: mild acute pancreatitis; MSAP: moderately severe acute pancreatitis; SAP: severe acute pancreatitis;

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Figure S1 Flowchart of the cohort process.

AP: acute pancreatitis; MAP: mild acute pancreatitis; MSAP: moderately severe acute pancreatitis; SAP: severe acute pancreatitis;

Pancreatic necrosis (n=472)

Treatment choices

Infected pancreatic necrosis (n=164) Sterile pancreatic necrosis (n=87)

Carbapenem resistant Enterobacteriaceae infected pancreatic necrosis (n=75)

Risk analysis Antimicrobial Susceptibility

Clinical outcome after 90 days of

intervention

Alive (n=37) Death (n=38)

Klebsiella pneumoniae

(n=84)

Microbial culture

Category AP (n=3960)

MAP (n=2693) MSAP (n=1069) SAP (n=198)

Conservative treatment (n=221) Therapeutic intervention (n=251)

Exclusion criteria:

(a) Age <18 or >80 years old;

(b) Incomplete medical records;

(c) Duplicated patients;

(d) Loss to follow-up Inclusion criteria:

(a) Clinical manifestations of carbapenem resistant Enterobacteriaceaeinfected

pancreatic necrosis;

(b) Hospitalization and complete clinical data

Escherichia coli (n=21)

Klebsiella ozaenae

(n=17)

Enterobacter cloacae

(n=5)

Proteus mirabilis

(n=4)

Proteus mirabilis

(n=4)

Enterobacter aerogenes

(n=2)

Klebsiella oxytoca

(n=2)

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