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Table S1. C-fiber ex vivo skin nerve preparation recorded from the hindpaw hairy skin. C- mechanoheat (CMH), C-mechanoheatcold (CMHC) and C-mechanocold (CMC) fibers were recorded from Npr2

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Table S1. C-fiber ex vivo skin nerve preparation recorded from the hindpaw hairy skin. C- mechanoheat (CMH), C-mechanoheatcold (CMHC) and C-mechanocold (CMC) fibers were recorded from Npr2fl/fl;Wnt1Cre mice and littermate controls. Mean CVs are shown +/- SEM.

Npr2fl/fl Npr2fl/fl;Wnt1Cre

Fiber Type % Total CV m/s % Total CV m/s

CMH 63.5

(21/33)

0.45 +/-0.06 62.5

(15/24)

0.41 +/-0.05

CMHC 24.5

(8/33)

0.27 +/-0.03 25

(6/24)

0.49 +/-0.13

CMC 12

(4/33)

0.78 +/-0.15 12.5

(3/24)

0.38 +/-0.15

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