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HelenaD.Smolarz ,EwarystMendyk ,AnnaBogucka-Kocka ,andJanuszKocki lapathifolium L.ssp. nodosum (Pers.)Dans Pinostrobin Ð AnAnti-LeukemicFlavonoidfrom Polygonum

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lapathifolium L. ssp. nodosum (Pers.) Dans

Helena D. Smolarz

a,*

, Ewaryst Mendyk

b

, Anna Bogucka-Kocka

a

, and Janusz Kocki

c

a Chief and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodz˙ki Str., 20-093 Lublin, Poland. E-mail: smolarz@am.lublin.pl

b Department of Chemistry, Analytical Laboratory, UMCS, M. Curie-Skłodowska Sq., Lublin, Poland

c Department of Medical Genetics, Medical University of Lublin, Lublin, Poland

* Author for correspondence and reprint requests

Z. Naturforsch.61 c, 64Ð68 (2006); received July 22/August 22, 2005

Aim of study: Search for plant compounds possessing anti-leukemic properties.

Results: We have shown that 5-hydroxy-7-methoxy flavanone (pinostrobin) isolated from Polygonum lapathifoliumssp.nodosumquickly penetrates through cytoplasm to the cellular nucleus of the cultured cells, and gives intensive apoptotic response in stimulating leukemic cellsin vitro.The number of apoptotic cells increased with the concentration of pinostrobin:

10 nmÐ25% and 60%; 100 nmÐ45% and 76%; 1µmÐ70% and 88% for Jurkat and HL60 cell lines, respectively.

Conclusion: Pinostrobin may be considered as a good candidate for a leukemia chemopre- ventic agent.

Key words:Pinostrobin,Polygonum lapathifoliumssp.nodosum, Anti-Leukemic Activity

Pinostrobin Ð An Anti-Leukemic Flavonoid from Polygonum

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