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SUPPLEMENTARY MATERIAL

Fig 1s. ISTERP-1. Schematic representation of the ISTERP-1 study protocol. All people from the Intervention Group, after being been followed-up until T+6, were enrolled in the ISTERP-2.

KP = KwikPen; Hypos = Hypoglycemic Episodes; GV = Glycemic Variability; CG = Control Group; IG = Intervention Group; SMBG = self-monitoring of blood glucose [reference 14]

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Fig 2s. Changes in needle reuse (%), missing site rotation (%), injection into LH nodules (%), and Daily Insulin Dose requirement (IU), with significance of observed differences. ** p <

0.001; * p< 0.05

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