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Inhibitory Effect of a Cyclic Urea Derivative on Rubella Virus Replication Angel S. Galabov

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Inhibitory Effect of a Cyclic Urea Derivative on Rubella Virus Replication

Angel S. Galabov

a,

*, Zefira Mihneva

b

,

Vessela Hadjiathanassova

b

and Vera Zhukovec

a

a Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia. Fax: (359Ð2) 700 109.

E-mail: galabov@microbio.bas.bg

b National Centre of Infectious and Parasitic Diseases, 1504 Sofia, Bulgaria

* Author for correspondence and reprint requests Z. Naturforsch.55 c,292Ð294 (2000);

received August 9, 1999/February 10, 2000 Cyclic Ureas, 1-(4-Morpholinomethyl)-tetrahydro- 2(1H)-pyrimidinone, Rubella Virus

1-(4-Morpholinomethyl)-tetrahydro-2(1H)-pyrimidi- none (mopyridone) exhibited a marked activity against rubella virus (Judith and RA27/3 strains), a MIC50value of 0.9µm and selectivity ratio of 557.7 been found in the case of Judith strain. These data, in addition to the previous ones about its anti-alphavirus effects suggest the compound to be considered as a broad spectrum in- hibitor of togavirus replication.

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