VolaƟ le Organic Compounds (VOC) sampled during bronchoscopy in lung cancer paƟ ents
* Korea InsƟ tute of Science and Technology Europe ForschungsgesellschaŌ mbH (KIST Europe) Campus E 7 1 - 66123 Saarbrücken - Germany
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Head of Department Microfl uidics and Clinical DiagnosƟ cs baumbach@kist-europe.de
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K. Darwiche 1 , J.I. Baumbach 2,3 , U. Sommerwerck 1 , H. Teschler 1 , L. Freitag 2
1 Ruhrlandklinik, Clinic for Pulmonology, University Hospital Essen, Tüschener Weg 40, 45239 Essen, Germany 2 KIST Europe, Department Microfl uidics and Clinical DiagnosƟ cs, Campus E 71, 66123 Saarbrücken, Germany
3 B&S AnalyƟ k, BioMedicalCenter Dortmund, OƩ o-Hahn-Str. 15, 44227 Dortmund, Germany
Acknowledgements The fi nancial support of the Ministry of Educa on,
Science and Technology (MEST) of the Republic Korea is acknowledged thankfully. Part of the work on this paper has been supported by Deutsche For- schungsgemeinscha (DFG) within the Collabora - ve Research Center (Sonderforschungsbereich) SFB 876 „Providing Informa on by Resource-Constrai- ned Analysis“, project TB1 “Resource-Constrained
Analysis of Spectrometry Data“.
In addi on, the work was supported partly by the German Federal Ministry of Economics and Tech- nology based on a decision of the German Bundes-
tag within the project KF2368102AKO.
Part Part Part Part Partartr
Ion mobility spectrome-
try coupled to a mul capillary co-
lumn (MCC/IMS) has the poten al for di-
agnosis of lung cancer. However, the origin of
specifi c vola le organic compounds (VOC) detected in pa ents with non-small-cell lung cancer (NSCLC) s ll
remains unknown. We wondered whether if the spectrum of VOCs in bronchi close to the tumour is diff erent to the VOCs in the bronchi of the contralateral lung in lung cancer pa ents.
10 Pa ents with histologically proven peripheral NSCLC were included in the study. During the diagnos c fl exible bron- choscopy a catheter connected to an MCC/IMS was in- troduced through the working channel of the bron- choscope. Gas samples were aspirated from the tumour bearing side and the contralateral
lung before biopsies of the tumour have been taken.
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