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Synthesis of C-Glycosides from S-Glycosyl Phosphorothioates

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Synthesis of C-Glycosides from S-Glycosyl Phosphorothioates

W. Kudelska

Institute of Chemistry, Faculty of Pharmacy, Medical University of Ło´dz´, 9 0Ð151 Ło´dz´, Muszyn´skiego 1, Poland

Reprint requests to Dr. W. Kudelska.

Fax: 48-42-678-83-98. E-mail: kudelska@ich.pharm.am.lodz.pl Z. Naturforsch.57b, 243Ð247 (2002); received October 16, 2001 S-Glycosyl Phosphorothioates,C-Glycosides, Synthesis

Treatment ofO-benzyl protectedS-glucosyl phosphorothioates with 1,3,5-trimethoxyben- zene in the presence of iodine or boron trifluoride etherate led to appropriate arylC-β-D- glucosides. The reaction ofO-benzyl andO-acetyl-protected phosphorothioates of monosac- charides with allyltrimethylsilane, using boron trifluoride etherate as activator, gave mainly or exclusively, the corresponding 3-(α-D- glycopyranosyl)-1-propenes.C-Glucosidation of fu- ran withO-benzyl protectedS- glucosyl phosphorothioate in the presence of boron trifluo- ride etherate afforded (2- furyl)-α-C-glucoside.

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