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S1 Fig: Flowchart on available studies2513 publications screened on the basis of publicly available information16 studies

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S1 Fig: Flowchart on available studies

2513 publications screened

on the basis of publicly available information

16 studies

dit not respond to multiple screening contacts

513 studies known to be ineligible

610 studies potentially eligible

60 cohorts known to be eligible

18 study teams declined collaboration

9 study teams failed to deliver data in

time 42 study teams

assured collaboration

2 cohorts could not be used as no

endpoints remained after exclusions 33 cohorts

delivered data

31 cohorts used in this report

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