• Keine Ergebnisse gefunden

Role of Peroxisome Proliferator Activated Receptor-alpha (PPARalpha) in cardiomyogenesis of mouse embryonic stem cells

N/A
N/A
Protected

Academic year: 2021

Aktie "Role of Peroxisome Proliferator Activated Receptor-alpha (PPARalpha) in cardiomyogenesis of mouse embryonic stem cells"

Copied!
146
0
0

Wird geladen.... (Jetzt Volltext ansehen)

Volltext

(1)    .   .  

(2)               

(3)

(4)  

(5)      

(6)  

(7)       .  

(8)

(9)  

(10)                          

(11) 

(12) !   " # 

(13) $

(14)

(15) %$       &     .  !". .  ' %    $

(16)

(17) ())*.

(18)       

(19)   +

(20)  %      %  

(21) 

(22) !  " # 

(23) $

(24)

(25) %  $     ,  -    .  + /     ,  ,  

(26) 

(27) !  " # 

(28) $

(29)

(30)    0 # 1 .  +  &    +

(31)  

(32)   

(33) 

(34) !  " # 

(35) $

(36)

(37)     +2 3

(38)

(39)         

(40)   

(41) 

(42) !  " # 

(43) $

(44)

(45)    4-  .  +"  5    $   

(46) 

(47)   

(48) 

(49) !  " # 

(50) $

(51)

(52)     4-  .  66   ())*               .

(53) ' 

(54) 

(55) 

(56)   

(57) 

(58)

(59) 1         7 ())8  ())*  

(60)  #

(61) +  &  

(62)   +

(63)  %     %

(64) 

(65) !   " # 

(66) %$

(67)

(68) %$ ' 

(69)  

(70)     

(71)  

(72)

(73)  1

(74) 

(75) 

(76)         $  0

(77)    % $   9  :;8 $ $0/ :;8%   $ 4-   , 

(78)   ,   &

(79)   4,,+&%     " # 

(80)   $

(81)

(82)  , #

(83)   0

(84)  ,   "$,<0                             .        .

(85)                 .  . .

(86)   

(87)            .

(88) 

(89)    . 2 1 9

(90)     =    #

(91)    

(92)  

(93)  9. 

(94) =   %1 9 

(95)  %    

(96)  1       9

(97) #    1 

(98)        

(99) 

(100)

(101)      #

(102)         

(103)   

(104) 

(105)   1 

(106) 

(107)

(108)  

(109) .   '      #     %        

(110) 

(111)       

(112) 

(113)         

(114)  

(115)        #      1

(116) 1  9 9 %    %  #         

(117)    .    #   

(118)   

(119)    >     

(120)

(121)    

(122)

(123)  #     %  %   

(124)

(125)       9   

(126) #     #   

(127)   

(128)  9

(129)   

(130)  

(131) %  % 

(132) % 9   

(133)    #    

(134)

(135)    .  1  9   -

(136)

(137)  

(138)        !" "   .  #       %          

(139)

(140)    

(141)     

(142) 

(143)                  

(144)  9     % 

(145)

(146)

(147)    

(148) 

(149)  

(150)  #   

(151)     

(152)   

(153) 

(154)

(155)  19

(156)   

(157)  .  

(158)  

(159) 

(160) 

(161) # 

(162)  

(163)  

(164)      .  

(165)  1       !" "    !% ,    . +

(166)   

(167)   %   #         19   

(168)

(169)     +

(170)  

(171)   % 

(172)    

(173) =  .  1  9   9    #$               .

(174)   

(175)  -

(176)

(177)      9

(178)     %&

(179)  '&  '  (%')* 

(180) 

(181) ?  

(182) 3  %1  #  #     #  $  . 1  9  -

(183)

(184) 

(185)           % . +%         

(186)

(187)   .  1  9   9  &   , -       . 

(188)   

(189) 

(190)

(191)   $ . . .

(192) . '9

(193)  %, -   &   + $ . .    !     $       /  0  $ 

(194)   

(195)  /   / !   & $    

(196) 

(197)

(198) 

(199)  

(200) 

(201)  

(202) 1

(203)  

(204)     1    9 

(205) 1  1   =#   

(206)  

(207) 1  #    1  =

(208)    

(209)     . 1 

(210)  9 9,   $, .  - .    

(211)

(212)

(213)   . 1  9 9  

(214)  

(215)   

(216)  +

(217)  

(218)   .    

(219)     . 19  

(220)  1 1

(221)  

(222)  $ %%"/%  "&.   

(223)       

(224)    . 3

(225)      ?   -

(226)

(227)   9

(228)   " $, 

(229) % ".   1,% "   %   " /    1    ? 

(230)

(231)  

(232)    .   %1  9 9 #  1

(233)    1. #    '  1 @  

(234)   1            . . .

(235)   .    #$"%&'()" ******************************************************************************************************! #%"" ******************************************************************************************************************************!!! '! %+' *************************************************************************************************************** ,!! '! %!)- ************************************************************************************************************,!!! ++,!!%" ***************************************************************************************************************** . /*!"%(-#!%"************************************************************************************************************** /0 6 6& ,

(236)  6: 6 6 6  

(237)  

(238)  6A 6 6 (+ 

(239) 

(240)  

(241)  6B 6 6 ;'

(242) 

(243)  

(244)  6* 6 6 ; 64 

(245)  

(246)  6* 6 6 ; (4  

(247)  () 6 6 ; ;C  

(248)  

(249)  () 6 ('      (6 6 ( 6+ -

(250)     #   

(251)  (( 6 ( 6 6

(252)  (( 6 ( 6 ($   

(253)   ++C0

(254)  (; 6 ( 6 ;++C0

(255) 

(256)  (A 6 ( 6 ; 6++C0  (A 6 ( 6 ; (++C0  (B 6 ( 6 ; ;++C0 (B 6 ;   -

(257)    (* 6 ; 6<

(258)   -

(259)    (D 6 ; (&

(260) 07&  (D 6 ; ( 62C+- 

(261)  (D 6 ; ( 6 6& 2C+- 

(262)  ;) 6 ; ( 6 (2C+- 

(263) 07&    ;( 6 ; ( ('      ;;. . .

(264) 6 ; ( ( 6&      ;; 6 ; ( ( (     ;8 6 ; ( ( ;  

(265)

(266)      ;A 6 8C  =  #

(267)  ;* 1*!' "(%( *************************************************************************************** 02 ( 6  

(268)  ;D ( 6 6& 

(269)  1

(270)  

(271) 

(272)  ;D ( 6 (    

(273)  8) ( 6 ;4?   8( ( 6 8 % 

(274)  

(275)   

(276)  8; ( ( 

(277)  8: ( ( 6,    8: ( ( 6 64 

(278)      8: ( ( 6 (,  #    

(279)  8A ( ( 6 ;, 

(280)    8B ( ( 6 8&  

(281)    

(282) 9

(283)  8* ( ( 6 :'  

(284)    #   

(285)  8* ( ( ('   

(286)  8D ( ( ;C

(287)

(288)

(289)

(290)      :) ( ( 8

(291)   4&  #  

(292)  :) ( ( : 

(293)

(294) 

(295)  :6 ( ( : 6

(296)  

(297)  :6 ( ( : (!

(298)  

(299)   

(300)   :( ( ( : ; 

(301)   

(302) >      :8 ( ( : 807&   

(303)

(304)   :: ( ( A4-   

(305) 1 02C  :: ( ( A 602C

(306)    :: ( ( A (2

(307)  

(308)    :A ( ( A ;4

(309)   02C  ?    :B ( ( A 82C

(310) 

(311)

(312)  :B ( ( A :0     # 

(313) 

(314)  

(315) +,0

(316)

(317)  :*. . <.

(318) ( ( A : 6+      ?  :* ( ( A : (4-   

(319)   A) ( ( A : ;4  

(320)   A( ( ( A A$  

(321)

(322)  A( ( ( B&

(323)    

(324)

(325)  A; 0* -' **************************************************************************************************************************** 34 ; 64-

(326)

(327) ++C0% % 02C        

(328) 4&

(329)  A8 ; (&     

(330)

(331)  

(332) 4&

(333) ++C0%EE 

(334) 

(335)  AB ; ( 6C

(336)

(337)

(338)

(339)   

(340) 

(341)  

(342)    

(343)    1 ++C0

(344) 

(345)  AB ; ( (4#   

(346) >      1 ++C0 

(347) 

(348)  AD ; ;"   # 

(349)

(350) ++C0

(351)   

(352) >   

(353)  B( ; 8C  ++C002C -

(354)

(355)   1 ++C0

(356)  3F68A8;  B; ; :4  ++C0 #   1 ++C0

(357) 3F68A8;  B8 ; AC #  

(358)    02C -

(359)

(360)   1 3F68A8; B: ; B 

(361)  02C -

(362)

(363)    

(364)   

(365)  1  ++C0

(366)    BD ; *4        

(367)

(368)  

(369) 

(370) ++C0    #   *) ; D$   07&  1 ++C0

(371) 

(372)  *8 ; 6)"   # 

(373)

(374) ++C0 E

(375)   07&     *A ; 66   ++C0   07&     

(376) #      *B ; 6(C  ++C0   07&   2C+- 

(377)    

(378)  *D ; 6;4 0  ++C0   07&    D6 ; 68       

(379) #  

(380) ++C0     

(381)

(382)  D(. . <.

(383) ; 6:1    ++C0     

(384)

(385)     2C+ - 

(386)  #  D8 ; 6A"    2C+- 

(387) 

(388) 

(389)   1 3F68A8; DA 4*(! #-. !%" ********************************************************************************************************************* 22. 8 6&     

(390)   66) 5* -6*********************************************************************************************************************** /// : 6&  666 : (G

(391)  

(392)

(393)  66( 3*'!- ***************************************************************************************************************** //0 7*! #''"%- ********************************************************************************************************* /07 B 6+    6;B B (7  

(394)  

(395)  

(396)  6;B B ;C #  6;D 8*#-!#-'-,! ************************************************************************************************** /49                         . . <.

(397)    .    ' 6.!

(398)     

(399) 

(400)  8( ' (.!

(401)  # 

(402) 

(403)  

(404) 

(405)    8; ' ;.,

(406)        

(407)  88 ' 8.

(408) 

(409) 1      

(410)  8D ' :.!

(411) 

(412) 

(413) 

(414) 1      

(415)  :) ' A.  

(416)   

(417)   

(418)   :( ' B.&     

(419)   :8 ' *.&    

(420) 

(421)  A6                             . . <.

(422)    .     6.     4&

(423)  6B   (.&   

(424) 

(425)   6D   ;.&   -

(426)     #     (8   8.7 >      

(427)  ++C0    #  

(428)  # ++C0.+H0 - (:   :.& 2C+- 

(429)  ;6   A.' 

(430) 

(431) 07&         

(432)    ;:   B.&   

(433)                 

(434)

(435)   ;A   *."     4&

(436)  8A   D.C

(437)   

(438)    

(439)      !,&  :;   6).02C -

(440)

(441) !!.%#% 2  4&        A*   66. 

(442) 

(443)  

(444)      1  ++C0

(445) 

(446)   A*   6(.4 ++C0

(447) 

(448)  

(449) > 4&  #     

(450)  B6   6;.4 ++C0

(451)  

(452) >   

(453)   B(   68.4 

(454)  ++C0

(455) 3F68A8;02C -

(456)

(457) !!. B;   6:.4 ++C0

(458)   # 

(459)   ++C0   

(460)  B8   6A.4 ++C0

(461)  

(462)    

(463)     

(464)  B*   6B.4 ++C0

(465) 02C -

(466)

(467)    

(468)    

(469)  *6   6*.4       ++C0   #  *;   6D.4 ++C0

(470) 

(471) 07&    *:   ().07&     1 ++C0 E

(472) 

(473)  *A   (6.0    

(474) #  

(475)  - 2+$++C0   07&    **. . <.

(476)   ((.4 2C+- 

(477)     ++C0   07&     D)   (;.0      -      3F68A8;    07&     D6   (8.       

(478) #  

(479) ++C0      

(480)

(481)   D;   (:.   ++C0        

(482)

(483)  2C+- 

(484)        D:   (A. 

(485)  02C -

(486)

(487)    

(488) 

(489) 2C+- 

(490)    1 ++C0

(491)  D*   (B.C    

(492)     

(493) 

(494) 

(495)   6)D                              . . H.

(496)      . ,  ( 4  C2  C2+  C&,

(497)       ,+  2C    ,04 ,(  ,;  ,:    ,   ! 4 &7 2C . 2'+  +  ''  4

(498)   4,

(499)  4'C 4$

(500)  4$  40/  400  4&

(501)  4',  C  ,&  ',    (, (, C (7(  4+4&  . .                                         .   

(502) 

(503)       C      C        C  

(504)  

(505)  

(506)   ,  ,04     ,  2C    C+

(507) 

(508)       ,         2C      (I%BI    

(509)   

(510)        I

(511)   4 I

(512)     

(513)  -   -     -    

(514)               4 

(515)  4  

(516)  4         4  

(517)  4  1 4-  

(518)     9 

(519)  4

(520)       4 

(521)  

(522)  4 

(523)    #           

(524)   

(525)  

(526)     (I%BI      

(527)   (I%BI      

(528)        + -  8 (  -    >  6 

(529)     -     . H.

(530) 

(531) B( 

(532) D) ,  ! 6  ! A   27&  C/  2/  9  /(+78 !  !,& !!  !    C+/

(533)  4  4  , (          02C 2C 'C 2(+78 2,   2C 2C+ 26  2C 24C  2     2+$ 27  27&  20  7(:;  7277 ;*  +&  +&' . .                                              .  

(534) 9 B(  

(535) 9 D)   

(536)

(537)    9 6   9 A 

(538) #

(539)     I

(540)        - 

(541) 

(542)  

(543) 9 

(544)    2(   9 

(545)  9   +

(546)

(547)    

(548)   !       !

(549)  

(550)   

(551)   !1 

(552)    ! 9        J!     #  9 

(553)

(554)  

(555)     

(556)    4

(557)   

(558)               

(559)

(560)          2C     

(561)    C. E&   

(562)      &    0            2         

(563)     2C   

(564) 6 2 2C 2

(565)

(566)    

(567)  2 9 2   2  2 (        2  -  2  - 

(568) 

(569)  2 

(570)   & -  + -    ;*    #  9 

(571)  +

(572)    

(573)    +

(574)    

(575)   1 ' H 6)). H.

(576) +,0   +$   +$, 6  +;/   +/,      ++C0

(577)   ++C0  ++C0  ++C0  ++04   +'+   ?+,0   02C   02

(578)   02&   07&   02C   0'   0H0  

(579)    &7   &'C'  &   '2  '0   '

(580)    ' H 6))  02C   "   ",+   <4$   #    <&,  3J7              . +  

(581)     +    # 1 ++C0 # 6 +

(582)  

(583)  ; 9 

(584)  + 9 

(585) , +   + -

(586)     #   

(587)  + -

(588)     #    + -

(589)     #    + -

(590)     #    ++C0

(591) 

(592)   

(593)  + 

(594)  

(595) 

(596)

(597)  K  #   

(598)      0    0  

(599)  0  #   

(600)  

(601)  0  # - 

(602)  

(603)  0 

(604)      0    0   H   &   & - 

(605) 

(606)  &  

(607)  

(608)   #

(609) 

(610)    & ' 

(611)

(612)  '     (   (  -   6%;    7  -  -   '

(613)      "  "  

(614)  <

(615)      1 <   <

(616)  

(617) 

(618)    3 . H.

(619) 6;.      . .      .      

(620)  

(621)   = 

(622)    #

(623)           . 1 C-  6:E(L     AE6)L   # A:  

(624)     1 

(625)   

(626) 

(627)        '          

(628) 

(629) .

(630)      #  

(631)        

(632)  -   : E 6)L   

(633)  1   

(634) 

(635) %   #  

(636)

(637)   ;) E 8)L   

(638)  1   #       ! 3444   " 5663 .     

(639)  

(640)     

(641)

(642)        

(643)  % 1 

(644)      .

(645)    

(646) 

(647)  

(648)   

(649)   

(650)  

(651)   # 

(652)

(653) %      

(654) % # 

(655)

(656) %     

(657)   1        - %       

(658)        1     

(659)  

(660)

(661)   '

(662)  #       

(663)   #        

(664)

(665) #      % 1  

(666)   =    

(667)   " 5665'   

(668)

(669) 

(670)   >    #    

(671)    

(672)

(673)   1  

(674)   

(675)     #

(676)   >       '   

(677)   ?

(678)     

(679) # #  

(680)       #    

(681)       #        

(682)

(683) 

(684)

(685)  . & #    

(686)       

(687) 

(688)   #  ? .    

(689)   

(690)    #     '     

(691)       

(692) %   #    

(693)  

(694)    #

(695)   > %   

(696) 

(697)  

(698) , 

(699)      

(700) % 1 # %      

(701)     

(702)        1 # %  

(703)   .  

(704) %   

(705)  

(706) 

(707)

(708) %    

(709) %  

(710)   

(711) %  #   

(712) 

(713)      

(714)          

(715)    . ,       

(716)      

(717)

(718) 

(719)  .   

(720)    

(721)    #       

(722)            #      '      #      

(723)    

(724)           

(725)

(726)       1 # %     9         E  # 

(727)  %   #   . .

(728)      . 68. 

(729)

(730)   

(731)  

(732) 1

(733)  #

(734)       

(735)

(736)

(737)         

(738) 1      

(739)   " 5667 .      

(740)  

(741) %   

(742)  #      % +9 

(743) @

(744) 

(745) 

(746) %  

(747) %.     =

(748)  

(749)     %       

(750)  

(751)  1            

(752) 

(753)

(754) %1 # %  #     

(755) 

(756)     

(757)  9 

(758)   9

(759) 

(760)   

(761)    . '   

(762)           M     

(763) N%  

(764)  .       

(765)    # 

(766)   %

(767)   

(768)     

(769)

(770)     

(771)        

(772)  '  

(773)  

(774)             

(775)   

(776)  1  1  

(777) 1   

(778)  #  % 1 #

(779) #   ?            

(780)      #   1    

(781)    0              

(782)   

(783)      #   

(784)           

(785)   

(786)     - 

(787)    #       

(788)  '   1     

(789)  

(790)      

(791)     -

(792)      1            

(793)      

(794)  >   #            

(795)       8   " 5669 . '  %

(796) 

(797) #  

(798)  

(799) 

(800)      .          -    

(801)     : 566; '

(802)         

(803)  -  " 344;   " 3444 <   " 5663%

(804) 9    

(805) 

(806)  

(807)  " 344; =

(808)   " 3447   " 5665%  >   

(809) 

(810)  ,  " 344;%   

(811) 

(812)  

(813)  " 344; 1   " 5665%

(814)  

(815)  

(816) -  " 3444%     # 

(817) -  " 5666    " 566>%  1  # 

(818)  

(819)   " 5663 ?  " 566;%   

(820)    #   

(821)   " 5665 ) -  " 5667%   

(822)   

(823)  1 

(824) 

(825)      

(826)  .  

(827)    91    

(828)  4& 

(829)  #        

(830)     .   

(831) %                

(832) %

(833) 

(834) 

(835)         

(836)    

(837)   

(838) %   

(839)  

(840)  

(841)               #   &     

(842) % 

(843)   91 

(844)   

(845)  4& 

(846)          

(847)     &        

(848)     .

(849)      . 6:. 

(850)  4& 

(851)     -.   &                    

(852)     " 347>'  

(853) 

(854)  

(855)   

(856)        

(857)          

(858)  

(859)       

(860)   9  '   

(861)   #

(862)      

(863)           

(864)        

(865)  

(866)  =

(867)   

(868)  

(869) 

(870) 

(871)  . 1 # %    

(872)

(873) 

(874)  1      

Referenzen

ÄHNLICHE DOKUMENTE

Anschließend unter Inkubation von Zelllinien HT 29, SW 480 und SW 620 mit Testsubstanzen Pioglitazon und Telmisartan, für maximal 72 Stunden MTT in den von uns

To test the hypothesis that the long-term stroke-protective effects of regular physical activity are mediated via up regulation of eNOS and enhanced neovascularization in a

In humanen und murinen Adipozyten wurde mit dem vollen PPAR γ -Agonisten Pioglitazon, sowie mit Telmisartan und Irbesartan, nicht jedoch mit Eprosartan, eine

Beim Vergleich der Gesamthemmung der Glitazone auf die MeWo Zellen ab einer Konzentration von 0,015 mM zeigt sich (siehe Abbildung 5.17.), dass Pioglitazone das Zellwachstum der

Enrichment  of  OCT4,  SOX2,  and  NANOG   within  various  classes  of  dynamic  genomic   regions  that  change  upon  differentiation  of   hESC. Values  are

H3K4me1 regions enriched for OCT4 binding sites frequently become HMRs in all three differentiated cell types, whereas NANOG and SOX2 sites are more prone to change to an HMR

Eine chronische Herzinsuffizienz hingegen entwickelt sich idiopathisch im Rahmen einer dilatativen Kardiomyopathie oder infolge koronarer Herzkrankheit, Myokardinfarkt,

Thus, the aim of this study was to investigate the role of PPAR α in the remodelling processes related to heart failure, in models of ischaemia (chronic