Choroid Plexus Epithelial
Gdf11Ttr Neuroblast
Gdf11Dcx
Endothelial Pecam1
Gdf11
Additional Figure 1
Oligodendrocyte
& OPCs Pdgfra, Olig1
Gdf11
Microglia Itgam Gdf11 Endothelial
Pecam1 Gdf11
A) B)
A) B)
Additional Figure 2
Dentate Gyrus 0
1 2 3
puncta / cell
Gdf11 Mstn
Gdf11 Mstn
B) C)
YoungOld
A)
Dentate Gyrus CA1 CA3
Additional Figure 3
Gdf11 Alk4 Alk5 Tgfβ1
0.0 0.5 1.0 1.5 2.0
2-ΔΔCt
Young Old
ns
ns
ns ns
DG CA1 CA3
0 2 4 6 8 10 12 14
Gdf11puncta/cell OldYoung
ns ns
ns
Controls Gdf11cKO 0
5 10 15 20
Gdf11puncta / cell
Gdf11CAG-Creflox/floxER; Gdf11flox/flox Gdf11cKO
✱
RNAscope
A) B)
qPCR
Additional Figure 4 Controls Gdf11cKO
0.0 0.5 1.0 1.5
2-ΔΔCt
Gdf11flox/flox
CAG-CreER; Gdf11flox/flox Gdf11cKO
✱