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Cytotoxic Chalcones and Flavanones from the Tree Bark of Cryptocarya costata Hanapi Usman

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Cytotoxic Chalcones and Flavanones from the Tree Bark of Cryptocarya costata

Hanapi Usman

a

, Euis H. Hakim

b,*

, Tjodi Harlim

a

, Muhammad N. Jalaluddin

a

, Yana M. Syah

b

, Sjamsul A. Achmad

b

, and Hiromitsu Takayama

c

a Chemistry Department, Hasanuddin University, Jalan Perintis Kemerdekaan, Makassar 90245, Indonesia

b Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia. E-mail: euis@indo.net.id

c Graduate School of Pharmaceutical Sciences, Chiba University, 1Ð33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

* Author for correspondence and reprint requests

Z. Naturforsch.61 c, 184Ð188 (2006); received September 22, 2005

A new flavanone, 7-hydroxy-5,6-dimethoxyflavanone (1), together with three other flavon- oids, didymocarpin (2), 2⬘,4⬘-dihydroxy-5⬘,6⬘-dimethoxychalcone (3), and isodidymocarpin (4), had been isolated from the methanol extract of the tree bark ofCryptocarya costata.

The structures of these compounds were determined based on spectral evidence, including UV, IR, 1-D and 2-D NMR, and mass spectra. Cytotoxic properties of compounds1Ð4were evaluated against murine leukemia P-388 cells. The chalcones3and 4were found to have substantial cytotoxicity with IC50of 5.7 and 11.1µm, respectively.

Key words: 7-Hydroxy-5,6-dimethoxyflavanone, Cryptocarya costata, Murine Leukemia P- 388 Cells

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