Reaction of Coumarin Derivatives with Nucleophiles in Aqueous Medium

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These include the use of surface-active ionic liquids for the extraction of natural products (Bica et al.), the an- timicrobial activity of imidazolium-based ionic liquids (Giernoth

Tetra-n-butyl ammonium bromide (TBAB) was found to be an efficient phase-transfer catalyst for the synthesis of pyrido[2,3-d]pyrimidines by one-pot reaction of 6-aminouracils,

The combined organic phases were evaporated, and the remain- ing residue was subjected to chromatography (silica gel, n- hexane-ethyl acetate 85:15) to afford 4 (1.72 g, 95.0 %) as

The use of base required in such reactions was obviated by performing the re- action in water which not only avoided the use of base but also gave good yields (75 – 90 %) within 4.0

A new series of coumarin and benzofuran derivatives were synthesized as potential non-nucleoside reverse transcriptase inhibitors (NNRTIs) by reacting,

Geiparvarin ( 1 ), a naturally occurring compound bear- ing a coumarin residue, has been shown to possess a significant inhibitory activity against a variety of cell lines

We can cleave the molecule into two main fragments: on the one hand there is a monomeric methylzinc bis(2- pyridylmethyl)amide with the metal atom in a distorted