Zusammenfassung
Abbildungsverzeichnis
Abbildungsverzeichnis
Abbildung 1.1: Überschneidungen metabolischer und entzündlicher
Signalwege ...6
Abbildung 1.2: Aktivierung des NF-κB-Signalweges durch TLR4...7
Abbildung 1.3: Adipozyten regulieren den Glukosestoffwechsel in Leber und Skelettmuskel via RBP4 ...10
Abbildung 1.4: Transport und Speicherung von Vitamin A ...13
Abbildung 2.1: 14-tägige adipozytäre Differenzierung der hMSC-Tert...22
Abbildung 2.2: 21-tägige adipozytäre Differenzierung der hMSC-Tert...23
Abbildung 3.1: Lipidakkumulation während der Differenzierung ...37
Abbildung 3.2: Differenzierungsabhängige RBP4-Expression ...39
Abbildung 3.3: Differenzierungsabhängige RBP4-Sekretion ...40
Abbildung 3.4: Inkubation mit VLDL (Transkriptionsebene) ...41
Abbildung 3.5: Inkubation mit VLDL (Sekretionsebene) ...42
Abbildung 3.6: Inkubation mit Liposomen und Retinol-Palmitat ...43
Abbildung 3.7: Inkubation der Liposomen mit Lipoproteinlipase (Transkriptionsebene)...44
Abbildung 3.8: Inkubation der Liposomen mit Lipoproteinlipase (Sekretionsebene)...45
Abbildung 3.9: Fettsäureabhängige Sekretion der Adipozytokine ...47
Abbildung 3.10: Inhibition des NF-κB-Signalweges (Transkriptionsebene) ...50
Abbildung 3.11: Inhibition des NF-κB-Signalweges (Sekretionsebene) ...52
Abbildung 3.12: Aktivierung des TLR4 ...54
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Danksagung
Danksagung
Frau Prof. Dr. Dr. h.c. Ulrike Beisiegel danke ich herzlich dafür, dass ich diese Arbeit am Institut für Biochemie und Molekularbiologie II durchführen durfte.
Mein ganz besonderer Dank gilt Privatdozent Dr. Jörg Heeren, nicht allein für das Thema, sondern insbesondere für die Betreuung und für die wertvollen Anregungen.
Den Mitarbeiterinnen des Labors Sandra Ehret, Dorothee Lasrich und Birgit Henkel danke ich für die Hilfsbereitschaft und die Unterstützung.
Des Weiteren gilt mein Dank Frau Dr. Janne Prawitt für die Überlassung von Arbeitsprotokollen.
Herrn Dr. Ludger Scheja möchte ich herzlich für viele interessante und hilfreiche Diskussionen danken.
Zuletzt möchte ich allen Kolleginnen und Kollegen des Instituts danken, die zu dieser Arbeit beigetragen haben.