1. Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV),
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Chronische Herzinsuffizienz -
Langfassung. 2012;(Version 1.5). Available at:
http://versorgungsleitlinien.de/themen/herzinsuffizienz/pdf/nvl_hi_lang.pdf
&lnkname= nvl_herzinsuffizienz_lang. Accessed August 19, 2012.
2. Bruckenberger E. Herzbericht 2010. Hannover; 2011:258.
3. Deutsches Herzzentrum Berlin. Jahresbericht 2011. 2011. Available at:
http://www.dhzb.de/fileadmin/user_upload/deutsche_Seite/download/Jahresberic ht_2011.pdf. Accessed August 18, 2012.
4. Kirklin JK, Naftel DC, Pagani FD, et al. Sixth INTERMACS annual report: A 10,000-patient database. J Heart Lung Transplant. 2014;33(6):555–64.
doi:10.1016/j.healun.2014.04.010.
5. Deutsche Stiftung Organtransplantation. Neuanmeldungen und Herztransplantationen. 2012. Available at:
http://www.dso.de/uploads/tx_dsodl/Grafiken_JB_2011_d_OT.zip. Accessed September 16, 2012.
6. Hsu DT, Pearson GD. Heart failure in children: part I: history, etiology, and pathophysiology. Circ Heart Fail. 2009;2(1):63–70.
doi:10.1161/CIRCHEARTFAILURE.108.820217.
7. Kantor PF, Lougheed J, Dancea A, et al. Presentation, diagnosis, and medical management of heart failure in children: Canadian Cardiovascular Society
guidelines. Can J Cardiol. 2013;29(12):1535–52. doi:10.1016/j.cjca.2013.08.008.
8. MacLaren G, Dodge-Khatami A, Dalton HJ, et al. Joint statement on mechanical circulatory support in children: a consensus review from the Pediatric Cardiac Intensive Care Society and Extracorporeal Life Support Organization. Pediatr Crit Care Med. 2013;14(5 Suppl 1):S1–2. doi:10.1097/PCC.0b013e318292dc09.
9. Davies RR, Haldeman S, McCulloch MA, Pizarro C. Ventricular assist devices as a bridge-to-transplant improve early post-transplant outcomes in children. J Heart Lung Transplant. 2014. doi:10.1016/j.healun.2014.02.010.
10. Mallidi HR, Anand J, Cohn WE. State of the art of mechanical circulatory support.
Tex Heart Inst J. 2014;41(2):115–20. doi:10.14503/THIJ-14-4143.
11. Berlin Heart GmbH. Berlin Heart EXCOR Pediatric. Available at:
http://www.berlinheart.de/index.php/mp/content/produkte/excor_pediatric/excor_p ediatric_pumpen. Accessed June 23, 2014.
size of Berlin Heart EXCOR pediatric device influences clinical outcome in children. J Heart Lung Transplant. 2014. doi:10.1016/j.healun.2014.03.007.
13. Almond CS, Morales DL, Blackstone EH, et al. Berlin Heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children.
Circulation. 2013;127(16):1702–11. doi:10.1161/CIRCULATIONAHA.112.000685.
14. HeartWare Inc. HeartWare Datasheet. Available at:
http://www.heartware.com/sites/default/files/uploads/resources/gl0007rev04_hvad _datasheet_rgb.pdf. Accessed August 17, 2014.
15. Miera O, Potapov E V, Redlin M, et al. First experiences with the HeartWare ventricular assist system in children. Ann Thorac Surg. 2011;91(4):1256–60.
doi:10.1016/j.athoracsur.2010.12.013.
16. Hayek S, Sims DB, Markham DW, Butler J, Kalogeropoulos AP. Assessment of right ventricular function in left ventricular assist device candidates. Circ
Cardiovasc Imaging. 2014;7(2):379–89. doi:10.1161/CIRCIMAGING.113.001127.
17. Ochiai Y, McCarthy PM, Smedira NG, et al. Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation. 2002;106(12 Suppl 1):I198–202. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/12354733. Accessed June 24, 2014.
18. Drakos SG, Janicki L, Horne BD, et al. Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am J Cardiol.
2010;105(7):1030–5. doi:10.1016/j.amjcard.2009.11.026.
19. Kirklin JK, Naftel DC, Stevenson LW, et al. INTERMACS database for durable devices for circulatory support: first annual report. J Heart Lung Transplant.
2008;27(10):1065–72. doi:10.1016/j.healun.2008.07.021.
20. INTERMACS. Interagency Registry for Mechanically Assisted Circulatory Support - Appendix A - Adverse Event Definitions. 2013. Available at:
http://www.uab.edu/medicine/intermacs/appendices-4-0/appendix-a-4-0.
Accessed June 24, 2014.
21. Pettinari M, Jacobs S, Rega F, Verbelen T, Droogne W, Meyns B. Are right ventricular risk scores useful? Eur J Cardiothorac Surg. 2012;42(4):621–6.
doi:10.1093/ejcts/ezs104.
22. Kalogeropoulos AP, Siwamogsatham S, Weinberger JF, et al. Clinical Scores and Echocardiography for Right Ventricular Failure Risk Prediction after Implantation of Continuous-Flow Left Ventricular Assist Devices. J Heart Lung Transplant.
2013;32(4):S273. Available at:
http://linkinghub.elsevier.com/retrieve/pii/S1053249813007298?showall=true.
23. Karimova A, Pockett CR, Lasuen N, et al. Right ventricular dysfunction in children supported with pulsatile ventricular assist devices. J Thorac Cardiovasc Surg.
2014;147(5):1691–1697.e1. doi:10.1016/j.jtcvs.2013.11.012.
24. Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and t. J Am Soc
Echocardiogr. 2010;23(7):685–713; quiz 786–8. doi:10.1016/j.echo.2010.05.010.
25. Potapov E V, Stepanenko A, Dandel M, et al. Tricuspid incompetence and geometry of the right ventricle as predictors of right ventricular function after implantation of a left ventricular assist device. J Heart Lung Transplant.
2008;27(12):1275–81. doi:10.1016/j.healun.2008.08.012.
26. Kukucka M, Stepanenko A, Potapov E, et al. Right-to-left ventricular end-diastolic diameter ratio and prediction of right ventricular failure with continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2011;30(1):64–9.
doi:10.1016/j.healun.2010.09.006.
27. Raina A, Seetha Rammohan HR, Gertz ZM, Rame JE, Woo YJ, Kirkpatrick JN.
Postoperative right ventricular failure after left ventricular assist device placement is predicted by preoperative echocardiographic structural, hemodynamic, and functional parameters. J Card Fail. 2013;19(1):16–24.
doi:10.1016/j.cardfail.2012.11.001.
28. Sachdeva R, Frazier EA, Jaquiss RDB, Imamura M, Swearingen CJ, Vyas H V.
Echocardiographic evaluation of ventricular assist devices in pediatric patients. J Am Soc Echocardiogr. 2013;26(1):41–9. doi:10.1016/j.echo.2012.08.012.
29. Feldman D, Pamboukian S V, Teuteberg JJ, et al. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support:
executive summary. J Heart Lung Transplant. 2013;32(2):157–87.
doi:10.1016/j.healun.2012.09.013.
30. Fan Y, Zhang A-M, Weng Y-G, et al. Factors associated with the need of biventricular mechanical circulatory support in children with advanced heart failure. Eur J Cardiothorac Surg. 2013;43(5):1028–35. doi:10.1093/ejcts/ezs481.
31. Sluysmans T, Colan SD. Structural Measurements and Adjustment for Growth. In:
Lai WW, Mertens LL, Cohen MS, Geva T, eds. Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult. Wiley-Blackwell Publishing;
2009:53 – 62.
32. Abbott RD, Gutgesell HP. Effects of heteroscedasticity and skewness on
prediction in regression: modeling growth of the human heart. Methods Enzymol.
1994;240:37–51. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7823839.
Accessed August 29, 2014.
surface area: a height-weight formula validated in infants, children, and adults. J Pediatr. 1978;93(1):62–6. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/650346. Accessed August 30, 2014.
34. Sluysmans T, Colan SD. Theoretical and empirical derivation of cardiovascular allometric relationships in children. J Appl Physiol. 2005;99(2):445–57.
doi:10.1152/japplphysiol.01144.2004.
35. Chubb H, Simpson JM. The use of Z-scores in paediatric cardiology. Ann Pediatr Cardiol. 2012;5(2):179–84. doi:10.4103/0974-2069.99622.
36. Robert Koch Institut. Referenzperzentile für anthropometrische Maßzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland.; 2010:56. Available at:
https://www.rki.de/DE/Content/Gesundheitsmonitoring/Gesundheitsberichterstattu ng/GBEDownloadsB/KiGGS_Referenzperzentile.pdf?__blob=publicationFile.
37. INO Therapeutics. The Effects of Nitric Oxide for Inhalation During Left
Ventricular Assists Device (LVAD) Implantation - iNOT-41 - ClinicalTrials.gov.
Available at: http://clinicaltrials.gov/ct2/show/study/NCT00060840. Accessed June 25, 2014.
38. Wernovsky G, Wypij D, Jonas RA, et al. Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest. Circulation.
1995;92(8):2226–35. Available at: http://www.ncbi.nlm.nih.gov/pubmed/7554206.
Accessed August 17, 2014.
39. Cruz DN, Antonelli M, Fumagalli R, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA.
2009;301(23):2445–52. doi:10.1001/jama.2009.856.
40. Shanewise JS, Cheung AT, Aronson S, et al. ASE/SCA guidelines for performing a comprehensive intraoperative multiplane transesophageal echocardiography examination: recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovasc.
Anesth Analg. 1999;89(4):870–84. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/10512257. Accessed June 25, 2014.
41. Henry WL, DeMaria A, Gramiak R, et al. Report of the American Society of Echocardiography Committee on Nomenclature and Standards in Two-dimensional Echocardiography. Circulation. 1980;62(2):212–7. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/7397962. Accessed September 7, 2014.
42. Koestenberger M, Ravekes W, Everett AD, et al. Right ventricular function in infants, children and adolescents: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values. J Am Soc Echocardiogr. 2009;22(6):715–9.
doi:10.1016/j.echo.2009.03.026.
43. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7(2):79–108.
doi:10.1016/j.euje.2005.12.014.
44. Dell’Italia LJ. The right ventricle: anatomy, physiology, and clinical importance.
Curr Probl Cardiol. 1991;16(10):653–720. Available at:
http://www.ncbi.nlm.nih.gov/pubmed/1748012. Accessed August 31, 2014.
45. Haddad F, Hunt SA, Rosenthal DN, Murphy DJ. Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation. 2008;117(11):1436–48.
doi:10.1161/CIRCULATIONAHA.107.653576.
46. Petitjean C, Rougon N, Cluzel P. Assessment of myocardial function: a review of quantification methods and results using tagged MRI. J Cardiovasc Magn Reson.
2005;7(2):501–16. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15881535.
Accessed August 31, 2014.
47. Kaul S, Tei C, Hopkins JM, Shah PM. Assessment of right ventricular function using two-dimensional echocardiography. Am Heart J. 1984;107(3):526–31.
Available at: http://www.ncbi.nlm.nih.gov/pubmed/6695697. Accessed August 31, 2014.
48. Koestenberger M, Nagel B, Ravekes W, et al. Systolic right ventricular function in preterm and term neonates: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 258 patients and calculation of Z-score values.
Neonatology. 2011;100(1):85–92. doi:10.1159/000322006.
49. Núñez-Gil IJ, Rubio MD, Cartón AJ, et al. Determination of normalized values of the tricuspid annular plane systolic excursion (TAPSE) in 405 Spanish children and adolescents. Rev española Cardiol. 2011;64(8):674–80.
doi:10.1016/j.recesp.2011.04.006.
50. López-Candales A, Rajagopalan N, Saxena N, Gulyasy B, Edelman K, Bazaz R.
Right ventricular systolic function is not the sole determinant of tricuspid annular motion. Am J Cardiol. 2006;98(7):973–7. doi:10.1016/j.amjcard.2006.04.041.
51. Hashimoto I, Nakagawa H, Shibata K, et al. Abstract 10983: Complementary Relationship of Right Ventricular Contraction Between Longitudinal and Radial Directions. Circulation. 2012;126(21_MeetingAbstracts):A10983–. Available at:
http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/
A10983. Accessed August 31, 2014.
52. Brittain EL, Hemnes AR, Keebler M, Lawson M, Byrd BF, Disalvo T. Right ventricular plasticity and functional imaging. Pulm Circ. 2012;2(3):309–26.
doi:10.4103/2045-8932.101407.
53. Ling LF, Obuchowski NA, Rodriguez L, Popovic Z, Kwon D, Marwick TH.
Accuracy and interobserver concordance of echocardiographic assessment of
Echocardiogr. 2012;25(7):709–13. doi:10.1016/j.echo.2012.03.018.
54. Kim J, Cohen SB, Atalay MK, Maslow AD, Poppas A. Quantitative Assessment of Right Ventricular Volumes and Ejection Fraction in Patients with Left Ventricular Systolic Dysfunction by Real Time Three-Dimensional Echocardiography versus Cardiac Magnetic Resonance Imaging. Echocardiography. 2014.
doi:10.1111/echo.12715.
55. Renella P, Marx GR, Zhou J, Gauvreau K, Geva T. Feasibility and reproducibility of three-dimensional echocardiographic assessment of right ventricular size and function in pediatric patients. J Am Soc Echocardiogr. 2014;27(8):903–10.
doi:10.1016/j.echo.2014.04.008.
56. Fusini L, Tamborini G, Gripari P, et al. Feasibility of intraoperative three-dimensional transesophageal echocardiography in the evaluation of right ventricular volumes and function in patients undergoing cardiac surgery. J Am Soc Echocardiogr. 2011;24(8):868–77. doi:10.1016/j.echo.2011.05.002.
57. Jamal F, Bergerot C, Argaud L, Loufouat J, Ovize M. Longitudinal strain
quantitates regional right ventricular contractile function. Am J Physiol Heart Circ Physiol. 2003;285(6):H2842–7. doi:10.1152/ajpheart.00218.2003.
58. Kato TS, Jiang J, Schulze PC, et al. Serial echocardiography using tissue Doppler and speckle tracking imaging to monitor right ventricular failure before and after left ventricular assist device surgery. JACC Heart Fail. 2013;1(3):216–22.
doi:10.1016/j.jchf.2013.02.005.
59. Grant ADM, Smedira NG, Starling RC, Marwick TH. Independent and incremental role of quantitative right ventricular evaluation for the prediction of right ventricular failure after left ventricular assist device implantation. J Am Coll Cardiol.
2012;60(6):521–8. doi:10.1016/j.jacc.2012.02.073.
60. Kalogeropoulos AP, Georgiopoulou V V, Siwamogsatham S, et al. Abstract 18379: Echocardiography for Right Ventricular Failure Prediction After Implantation of Left Ventricular Assist Devices: Preliminary Results From a
Prospective Cohort Study. Circulation. 2013;128(22_MeetingAbstracts):A18379–.
Available at:
http://circ.ahajournals.org/cgi/content/meeting_abstract/128/22_MeetingAbstracts/
A18379?sid=305948fc-3335-4ab3-a3c2-323511a5ff69. Accessed September 7, 2014.
61. Cameli M, Lisi M, Righini FM, et al. Speckle tracking echocardiography as a new technique to evaluate right ventricular function in patients with left ventricular assist device therapy. J Heart Lung Transplant. 2013;32(4):424–30.
doi:10.1016/j.healun.2012.12.010.
62. Stein ML, Robbins R, Sabati AA, et al. Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)-defined morbidity and mortality associated with pediatric ventricular assist device support at a single US center:
the Stanford experience. Circ Heart Fail. 2010;3(6):682–8.
doi:10.1161/CIRCHEARTFAILURE.109.918672.
63. Wilmot I, Morales DLS, Price JF, et al. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail.
2011;17(6):487–94. doi:10.1016/j.cardfail.2011.02.008.
64. Hamdan R, Mansour H, Nassar P, Saab M. Prevention of Right Heart Failure After Left Ventricular Assist Device Implantation by Phosphodiesterase 5 Inhibitor.
Artif Organs. 2014. doi:10.1111/aor.12277.
65. Tousignant C, Desmet M, Bowry R, Harrington AM, Cruz JD, Mazer CD. Speckle tracking for the intraoperative assessment of right ventricular function: a feasibility study. J Cardiothorac Vasc Anesth. 2010;24(2):275–9.
doi:10.1053/j.jvca.2009.10.022.
„Ich, Matthias Hommel, versichere an Eides statt durch meine eigenhändige Unter-schrift, dass ich die vorgelegte Dissertation mit dem Thema: Echokardiographische Prognose eines Rechtsherzversagens nach Implantation eines pädiatrischen Left Ventricular Assist Device selbstständig und ohne nicht offengelegte Hilfe Dritter verfasst und keine anderen als die angegebenen Quellen und Hilfsmittel genutzt habe.
Alle Stellen, die wörtlich oder dem Sinne nach auf Publikationen oder Vorträgen ande-rer Autoren beruhen, sind als solche in korrekter Zitierung (siehe „Uniform Require-ments for Manuscripts (URM)“ des ICMJE -www.icmje.org) kenntlich gemacht. Die Ab-schnitte zu Methodik (insbesondere praktische Arbeiten, Laborbestimmungen, statisti-sche Aufarbeitung) und Resultaten (insbesondere Abbildungen, Graphiken und Tabel-len) entsprechen den URM (s.o) und werden von mir verantwortet.
Meine Anteile an etwaigen Publikationen zu dieser Dissertation entsprechen denen, die in der untenstehenden gemeinsamen Erklärung mit dem Betreuer, angegeben sind.
Sämtliche Publikationen, die aus dieser Dissertation hervorgegangen sind und bei de-nen ich Autor bin, entsprechen den URM (s.o) und werden von mir verantwortet.
Die Bedeutung dieser eidesstattlichen Versicherung und die strafrechtlichen Folgen einer unwahren eidesstattlichen Versicherung (§156,161 des Strafgesetzbuches) sind mir bekannt und bewusst.“
Datum Unterschrift
7 Lebenslauf
Mein Lebenslauf wird aus datenschutzrechtlichen Gründen in der elektronischen Versi-on der Arbeit nicht veröffentlicht.
Deja, M., Hommel, M., Goldmann, A., Pille, C., von Dossow, V., Lojewski, C., & Spies, C.
(2008). [Lung diseases--multimodal adult respiratory distress syndrome(ARDS)--therapy requires evidence-based studies with clear criteria of results]. Anästhesiologie, Intensiv-medizin, NotfallIntensiv-medizin, Schmerztherapie : AINS, 43(11-12), 756–7. doi:10.1055/s-0028-1104615
Deja, M., Hommel, M., Weber-Carstens, S., Moss, M., von Dossow, V., Sander, M., … Spies, C.
(2008). Evidence-based therapy of severe acute respiratory distress syndrome: an algo-rithm-guided approach. The Journal of International Medical Research, 36(2), 211–21. Ret-rieved from http://www.ncbi.nlm.nih.gov/pubmed/18380929
Deja, M., Lojewski, C., Hommel, M., Menk, M., & Weimann, J. (2008). [Epidemiology and Pa-thophysiology of the acute respiratory distress syndrome (ARDS)]. Anästhesiologie, Inten-sivmedizin, Notfallmedizin, Schmerztherapie : AINS, 43(11-12), 758–66; quiz 768.
doi:10.1055/s-0028-1104616
Gottschalk, A., Raabe, A., Hommel, M., Rempf, C., Freitag, M., & Standl, T. (2005). Influence of the hemoglobin solution HBOC-201 on tissue oxygenation in the rat R1H-tumor. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 33(4), 379–89. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16317957
Hommel, M., Deja, M., von Dossow, V., Diemel, K., Heidenhain, C., Spies, C., &
Weber-Carstens, S. (2008). Bronchial fistulae in ARDS patients: management with an extracorpo-real lung assist device. The European Respiratory Journal : Official Journal of the Euro-pean Society for Clinical Respiratory Physiology, 32(6), 1652–5.
doi:10.1183/09031936.00021008
Raabe, A., Gottschalk, A., Hommel, M., Dubben, H.-H., & Strandl, T. (2005). No effect of the hemoglobin solution HBOC-201 on the response of the rat R1H tumor to fractionated irra-diation. Strahlentherapie Und Onkologie : Organ Der Deutschen Röntgengesellschaft ... [et Al], 181(11), 730–7. doi:10.1007/s00066-005-1418-3
Weber-Carstens, S., Bercker, S., Hommel, M., Deja, M., MacGuill, M., Dreykluft, C., & Kaisers, U. (2009). Hypercapnia in late-phase ALI/ARDS: providing spontaneous breathing using pumpless extracorporeal lung assist. Intensive Care Med, 35(6), 1100–1105.
doi:10.1007/s00134-009-1426-3