Abbott, L. F. & Regehr, W. G. (2004). Synaptic computation. Nature 431, 796-803.
Allen, R. C. (1999). David Hartley on Human Nature State University of New York Press.
Atwood, H. L. & Karunanithi, S. (2002). Diversification of synaptic strength: presynaptic elements. Nat.Rev.Neurosci. 3, 497-516.
Bernard, C. (1883). Lecons sur les Effets du Substances Toxiques et Medicamenteuses.
Blatow, M., Caputi, A., Burnashev, N., Monyer, H., & Rozov, A. (2003). Ca2+ buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals. Neuron 38, 79-88.
Bliss, T. V. & Collingridge, G. L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
Bortolotto, Z. A., Clarke, V. R., Delany, C. M., Parry, M. C., Smolders, I., Vignes, M., Ho, K.
H., Miu, P., Brinton, B. T., Fantaske, R., Ogden, A., Gates, M., Ornstein, P. L., Lodge, D., Bleakman, D., & Collingridge, G. L. (1999). Kainate receptors are involved in synaptic plasticity. Nature 402, 297-301.
Bortolotto, Z. A., Nistico, R., More, J. C., Jane, D. E., & Collingridge, G. L. (2005). Kainate receptors and mossy fiber LTP. Neurotoxicology 26, 769-777.
Bredt, D. S. & Nicoll, R. A. (2003). AMPA receptor trafficking at excitatory synapses.
Neuron 40, 361-379.
Breustedt, J., Vogt, K. E., Miller, R. J., Nicoll, R. A., & Schmitz, D. (2003). Alpha1E-containing Ca2+ channels are involved in synaptic plasticity. Proc.Natl.Acad.Sci.U.S.A 100, 12450-12455.
Calakos, N., Schoch, S., Sudhof, T. C., & Malenka, R. C. (2004). Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron 42, 889-896.
Carter, A. G., Vogt, K. E., Foster, K. A., & Regehr, W. G. (2002). Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. J.Neurosci. 22, 21-28.
Castillo, P. E., Janz, R., Sudhof, T. C., Tzounopoulos, T., Malenka, R. C., & Nicoll, R. A.
(1997). Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature 388, 590-593.
Castillo, P. E., Schoch, S., Schmitz, F., Sudhof, T. C., & Malenka, R. C. (2002). RIM1alpha is required for presynaptic long-term potentiation. Nature 415, 327-330.
Castillo, P. E., Weisskopf, M. G., & Nicoll, R. A. (1994). The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation. Neuron 12, 261-269.
Catterall, W. A., Perez-Reyes, E., Snutch, T. P., & Striessnig, J. (2005). International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol.Rev. 57, 411-425.
Collingridge, G. L., Isaac, J. T., & Wang, Y. T. (2004). Receptor trafficking and synaptic plasticity. Nat.Rev.Neurosci. 5, 952-962.
Collingridge, G. L., Olsen, R. W., Peters, J., & Spedding, M. (2009). A nomenclature for ligand-gated ion channels. Neuropharmacology 56, 2-5.
Contractor, A., Swanson, G., & Heinemann, S. F. (2001). Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 29, 209-216.
Dietrich, D., Kirschstein, T., Kukley, M., Pereverzev, A., von der, B. C., Schneider, T., &
Beck, H. (2003). Functional specialization of presynaptic Cav2.3 Ca2+ channels. Neuron 39, 483-496.
Dulubova, I., Lou, X., Lu, J., Huryeva, I., Alam, A., Schneggenburger, R., Sudhof, T. C., &
Rizo, J. (2005). A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? EMBO J. 24, 2839-2850.
Fessard, A. (1967). Claude Bernard and the physiology of junctional transmission. In Claude Bernard and Experimental Medicine, eds. Grande, F. & Visscher, M. B., pp. 105-124.
Schenkmann Pub. Co. Inc., Cambridge MA.
Forsythe, I. D. (1994). Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro. J.Physiol 479 ( Pt 3), 381-387.
Gasparini, S., Kasyanov, A. M., Pietrobon, D., Voronin, L. L., & Cherubini, E. (2001).
Presynaptic R-type calcium channels contribute to fast excitatory synaptic transmission in the rat hippocampus. J.Neurosci. 21, 8715-8721.
91
Geiger, J. R. & Jonas, P. (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K(+) channels in hippocampal mossy fiber boutons. Neuron 28, 927-939.
Harris, E. W. & Cotman, C. W. (1986). Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl D-aspartate antagonists. Neurosci.Lett. 70, 132-137.
Hartley, D. (1749). Observations on Man, His Frame, His Duty and His Expectations James Leake and WM Frederick, Bookfellers in Bath, London.
Henze, D. A., Urban, N. N., & Barrionuevo, G. (2000). The multifarious hippocampal mossy fiber pathway: a review. Neuroscience 98, 407-427.
Herlitze, S., Garcia, D. E., Mackie, K., Hille, B., Scheuer, T., & Catterall, W. A. (1996).
Modulation of Ca2+ channels by G-protein beta gamma subunits. Nature 380, 258-262.
Kaeser, P. S., Kwon, H. B., Blundell, J., Chevaleyre, V., Morishita, W., Malenka, R. C., Powell, C. M., Castillo, P. E., & Sudhof, T. C. (2008). RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.
Proc.Natl.Acad.Sci.U.S.A 105, 14680-14685.
Kajikawa, Y., Saitoh, N., & Takahashi, T. (2001). GTP-binding protein beta gamma subunits mediate presynaptic calcium current inhibition by GABA(B) receptor.
Proc.Natl.Acad.Sci.U.S.A 98, 8054-8058.
Kamiya, H. & Ozawa, S. (1999). Dual mechanism for presynaptic modulation by axonal metabotropic glutamate receptor at the mouse mossy fibre-CA3 synapse. J.Physiol 518 ( Pt 2), 497-506.
Kamiya, H., Ozawa, S., & Manabe, T. (2002). Kainate receptor-dependent short-term
plasticity of presynaptic Ca2+ influx at the hippocampal mossy fiber synapses. J.Neurosci. 22, 9237-9243.
Kamiya, H., Shinozaki, H., & Yamamoto, C. (1996). Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses. J.Physiol 493 ( Pt 2), 447-455.
Katsuki, H., Kaneko, S., Tajima, A., & Satoh, M. (1991). Separate mechanisms of long-term potentiation in two input systems to CA3 pyramidal neurons of rat hippocampal slices as revealed by the whole-cell patch-clamp technique. Neurosci.Res. 12, 393-402.
Katz, B. & Miledi, R. (1968). The role of calcium in neuromuscular facilitation. J.Physiol 195, 481-492.
Klausnitzer, J. & Manahan-Vaughan, D. (2008). Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats is regulated by adenosine A1 receptors. J.Neurosci. 28, 4836-4840.
Kobayashi, K. & Poo, M. M. (2004). Spike train timing-dependent associative modification of hippocampal CA3 recurrent synapses by mossy fibers. Neuron 41, 445-454.
Kukley, M., Schwan, M., Fredholm, B. B., & Dietrich, D. (2005). The role of extracellular adenosine in regulating mossy fiber synaptic plasticity. J.Neurosci. 25, 2832-2837.
Kwon, H. B. & Castillo, P. E. (2008a). Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses. Neuron 57, 108-120.
Kwon, H. B. & Castillo, P. E. (2008b). Role of glutamate autoreceptors at hippocampal mossy fiber synapses. Neuron 60, 1082-1094.
Lauri, S. E., Bortolotto, Z. A., Nistico, R., Bleakman, D., Ornstein, P. L., Lodge, D., Isaac, J.
T., & Collingridge, G. L. (2003). A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron 39, 327-341.
Lauri, S. E., Delany, C., VR, J. C., Bortolotto, Z. A., Ornstein, P. L., Isaac, T. R., &
Collingridge, G. L. (2001). Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.
Neuropharmacology 41, 907-915.
Leutgeb, J. K., Leutgeb, S., Moser, M. B., & Moser, E. I. (2007). Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 315, 961-966.
Li, J. Y., Plomann, M., & Brundin, P. (2003). Huntington's disease: a synaptopathy? Trends Mol.Med. 9, 414-420.
Li, L., Bischofberger, J., & Jonas, P. (2007). Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons. J.Neurosci. 27, 13420-13429.
Lin, D. T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K., & Huganir, R. L.
(2009). Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation. Nat.Neurosci. 12, 879-887.
Malenka, R. C. & Bear, M. F. (2004). LTP and LTD: an embarrassment of riches. Neuron 44, 5-21.
93
Malenka, R. C. & Nicoll, R. A. (1999). Long-term potentiation--a decade of progress? Science 285, 1870-1874.
Marr, D. (1971). Simple memory: a theory for archicortex. Philos.Trans.R.Soc.Lond B Biol.Sci. 262, 23-81.
Martin, S. J., Grimwood, P. D., & Morris, R. G. (2000). Synaptic plasticity and memory: an evaluation of the hypothesis. Annu.Rev.Neurosci. 23, 649-711.
McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007). Dentate gyrus NMDA
receptors mediate rapid pattern separation in the hippocampal network. Science 317, 94-99.
Mellor, J. & Nicoll, R. A. (2001). Hippocampal mossy fiber LTP is independent of postsynaptic calcium. Nat.Neurosci. 4, 125-126.
Miyazaki, K., Ishizuka, T., & Yawo, H. (2005). Synapse-to-synapse variation of calcium channel subtype contributions in large mossy fiber terminals of mouse hippocampus.
Neuroscience 136, 1003-1014.
Moore, K. A., Nicoll, R. A., & Schmitz, D. (2003). Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Proc.Natl.Acad.Sci.U.S.A 100, 14397-14402.
More, J. C., Nistico, R., Dolman, N. P., Clarke, V. R., Alt, A. J., Ogden, A. M., Buelens, F. P., Troop, H. M., Kelland, E. E., Pilato, F., Bleakman, D., Bortolotto, Z. A., Collingridge, G. L.,
& Jane, D. E. (2004). Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47, 46-64.
Nakazawa, K., Quirk, M. C., Chitwood, R. A., Watanabe, M., Yeckel, M. F., Sun, L. D., Kato, A., Carr, C. A., Johnston, D., Wilson, M. A., & Tonegawa, S. (2002). Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297, 211-218.
Nicoll, R. A. & Schmitz, D. (2005). Synaptic plasticity at hippocampal mossy fibre synapses.
Nat.Rev.Neurosci. 6, 863-876.
Nicoll, R. A., Tomita, S., & Bredt, D. S. (2006). Auxiliary subunits assist AMPA-type glutamate receptors. Science 311, 1253-1256.
Pinheiro, P. S., Perrais, D., Coussen, F., Barhanin, J., Bettler, B., Mann, J. R., Malva, J. O., Heinemann, S. F., & Mulle, C. (2007). GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses. Proc.Natl.Acad.Sci.U.S.A 104, 12181-12186.
Ramon y Cajal, S. (1899). Textura del Sistema Nervioso del Hombre y de los Vertebrados Moya, Madrid, Spain.
Reid, C. A., Dixon, D. B., Takahashi, M., Bliss, T. V., & Fine, A. (2004). Optical quantal analysis indicates that long-term potentiation at single hippocampal mossy fiber synapses is expressed through increased release probability, recruitment of new release sites, and activation of silent synapses. J.Neurosci. 24, 3618-3626.
Rolls, E. T. & Kesner, R. P. (2006). A computational theory of hippocampal function, and empirical tests of the theory. Prog.Neurobiol. 79, 1-48.
Rosenmund, C., Sigler, A., Augustin, I., Reim, K., Brose, N., & Rhee, J. S. (2002).
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron 33, 411-424.
Sachidhanandam, S., Blanchet, C., Jeantet, Y., Cho, Y. H., & Mulle, C. (2009). Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses. J.Neurosci. 29, 5000-5008.
Salin, P. A., Malenka, R. C., & Nicoll, R. A. (1996a). Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron 16, 797-803.
Salin, P. A., Scanziani, M., Malenka, R. C., & Nicoll, R. A. (1996b). Distinct short-term plasticity at two excitatory synapses in the hippocampus. Proc.Natl.Acad.Sci.U.S.A 93, 13304-13309.
Schmitz, D., Mellor, J., Frerking, M., & Nicoll, R. A. (2001a). Presynaptic kainate receptors at hippocampal mossy fiber synapses. Proc.Natl.Acad.Sci.U.S.A 98, 11003-11008.
Schmitz, D., Mellor, J., & Nicoll, R. A. (2001b). Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses. Science 291, 1972-1976.
Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Sudhof, T. C. (2002). RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature 415, 321-326.
Schwenk, J., Harmel, N., Zolles, G., Bildl, W., Kulik, A., Heimrich, B., Chisaka, O., Jonas, P., Schulte, U., Fakler, B., & Klocker, N. (2009). Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 323, 1313-1319.
Scott, R., Lalic, T., Kullmann, D. M., Capogna, M., & Rusakov, D. A. (2008). Target-cell specificity of kainate autoreceptor and Ca2+-store-dependent short-term plasticity at hippocampal mossy fiber synapses. J.Neurosci. 28, 13139-13149.
95
Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science 298, 789-791.
Shen, L., Liang, F., Walensky, L. D., & Huganir, R. L. (2000). Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J.Neurosci.
20, 7932-7940.
Sherrington, C. S. (1906). Integrative Action of the Nervous System Yale Univeristy,New Haven.
Shimizu, H., Fukaya, M., Yamasaki, M., Watanabe, M., Manabe, T., & Kamiya, H. (2008).
Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse. Proc.Natl.Acad.Sci.U.S.A 105, 11998-12003.
Smolders, I., Bortolotto, Z. A., Clarke, V. R., Warre, R., Khan, G. M., O'Neill, M. J., Ornstein, P. L., Bleakman, D., Ogden, A., Weiss, B., Stables, J. P., Ho, K. H., Ebinger, G., Collingridge, G. L., Lodge, D., & Michotte, Y. (2002). Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nat.Neurosci. 5, 796-804.
Takahashi, T., Kajikawa, Y., & Tsujimoto, T. (1998). G-Protein-coupled modulation of presynaptic calcium currents and transmitter release by a GABAB receptor. J.Neurosci. 18, 3138-3146.
Thomson, A. M. (2003). Presynaptic frequency- and pattern-dependent filtering.
J.Comput.Neurosci. 15, 159-202.
Tong, G., Malenka, R. C., & Nicoll, R. A. (1996). Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasticity. Neuron 16, 1147-1157.
Tottene, A., Volsen, S., & Pietrobon, D. (2000). alpha(1E) subunits form the pore of three cerebellar R-type calcium channels with different pharmacological and permeation properties.
J.Neurosci. 20, 171-178.
Turecek, R. & Trussell, L. O. (2001). Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse. Nature 411, 587-590.
Urban, N. N., Henze, D. A., & Barrionuevo, G. (2001). Revisiting the role of the hippocampal mossy fiber synapse. Hippocampus 11, 408-417.
Varoqueaux, F., Sigler, A., Rhee, J. S., Brose, N., Enk, C., Reim, K., & Rosenmund, C.
(2002). Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.
Proc.Natl.Acad.Sci.U.S.A 99, 9037-9042.
Weisskopf, M. G. & Nicoll, R. A. (1995). Presynaptic changes during mossy fibre LTP revealed by NMDA receptor-mediated synaptic responses. Nature 376, 256-259.
Weisskopf, M. G., Zalutsky, R. A., & Nicoll, R. A. (1993). The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation. Nature 365, 188.
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006). Learning induces long-term potentiation in the hippocampus. Science 313, 1093-1097.
Wojtowicz, J. M. & Atwood, H. L. (1986). Long-term facilitation alters transmitter releasing properties at the crayfish neuromuscular junction. J.Neurophysiol. 55, 484-498.
Xu-Friedman, M. A. & Regehr, W. G. (2004). Structural contributions to short-term synaptic plasticity. Physiol Rev. 84, 69-85.
Yamakawa, H. & Ohara, O. (2000). Comparison of mRNA and protein levels of four members of the protein 4.1 family: the type II brain 4.1/4.1B/KIAA0987 is the most predominant member of the protein 4.1 family in rat brain. Gene 248, 137-145.
Yeckel, M. F., Kapur, A., & Johnston, D. (1999). Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism. Nat.Neurosci. 2, 625-633.
Zalutsky, R. A. & Nicoll, R. A. (1990). Comparison of two forms of long-term potentiation in single hippocampal neurons. Science 248, 1619-1624.
Zalutsky, R. A. & Nicoll, R. A. (1992). Mossy fiber long-term potentiation shows specificity but no apparent cooperativity. Neurosci.Lett. 138, 193-197.
Zucker, R. S. & Regehr, W. G. (2002). Short-term synaptic plasticity. Annu.Rev.Physiol 64, 355-405.
97