NK and CD4+ T cell changes in blood after seizures in temporal lobe epilepsy.
Exp Neurol, 2008. 211:370-377.
11. Billiau AD, Witters P, Ceulemans B, Kasran A, Wouters C, and Lagae L.
Intravenous immunoglobulins in refractory childhood-onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokine profile.
Epilepsia, 2007. 48:1739-1749.
12. Blaheta RA and Cinatl J, Jr. Anti-tumor mechanisms of valproate: a novel role for an old drug. Med Res Rev, 2002. 22:492-511.
13. Blumcke I, Beck H, Lie AA, and Wiestler OD. Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res, 1999. 36:205-223.
14. Blumcke I, Thom M, and Wiestler OD. Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy. Brain Pathol, 2002. 12:199-211.
15. Boer K, Spliet WG, van Rijen PC, Redeker S, Troost D, and Aronica E.
Evidence of activated microglia in focal cortical dysplasia. J Neuroimmunol, 2006. 173:188-195.
16. Borish LC and Steinke JW. 2. Cytokines and chemokines. J Allergy Clin Immunol, 2003. 111:S460-S475.
17. Bumanglag AV and Sloviter RS. Minimal latency to hippocampal epileptogenesis and clinical epilepsy after perforant pathway stimulation-induced status epilepticus in awake rats. J Comp Neurol, 2008. 510:561-580.
18. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, and Mucke L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A, 1993. 90:10061-10065.
19. Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, and Gahring LC.
Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol, 1999.
163:3963-3968.
20. Carta S, Tassi S, Semino C, Fossati G, Mascagni P, Dinarello CA, and Rubartelli A. Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood, 2006.
108:1618-1626.
21. Chaplin DD. 1. Overview of the human immune response. J Allergy Clin Immunol, 2006. 117:S430-S435.
22. Chen G, Castro WL, Chow HH, and Reichlin S. Clearance of 125I-labeled interleukin-6 from brain into blood following intracerebroventricular injection in rats. Endocrinology, 1997. 138:4830-4836.
23. Crespel A, Coubes P, Rousset MC, Brana C, Rougier A, Rondouin G, Bockaert J, Baldy-Moulinier M, and Lerner-Natoli M. Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis. Brain Res, 2002. 952:159-169.
24. Curfs JH, Meis JF, and Hoogkamp-Korstanje JA. A primer on cytokines:
sources, receptors, effects, and inducers. Clin Microbiol Rev, 1997. 10:742-780.
25. D'Arcangelo G, Tancredi V, Onofri F, D'Antuono M, Giovedi S, and Benfenati F. Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex. Eur J Neurosci, 2000. 12:1241-1252.
26. De Laurentiis A, Pisera D, Lasaga M, Diaz M, Theas S, Duvilanski B, and Seilicovich A. Effect of interleukin-6 and tumor necrosis factor-alpha on GABA release from mediobasal hypothalamus and posterior pituitary.
Neuroimmunomodulation, 2000. 7:77-83.
27. De Sarro G, Russo E, Ferreri G, Giuseppe B, Flocco MA, Di Paola ED, and De Sarro A. Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice. Pharmacol Biochem Behav, 2004. 77:761-766.
28. De Simoni MG, Perego C, Ravizza T, Moneta D, Conti M, Marchesi F, De Luigi A, Garattini S, and Vezzani A. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur J Neurosci, 2000. 12:2623-2633.
29. Dube C, Vezzani A, Behrens M, Bartfai T, and Baram TZ. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol, 2005. 57:152-155.
30. Egger G. Die Akute Entzündung - Grundlagen, Pathophysiologie und klinische Erscheinungsbilder der Unspezifischen Immunität. Springer Wien New York 2005.
31. Engel J, Jr. Mesial temporal lobe epilepsy: what have we learned?
Neuroscientist, 2001. 7:340-352.
32. Fisher RS, van Emde BW, Blume W, Elger C, Genton P, Lee P, and Engel J, Jr. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005. 46:470-472.
33. Frost RA, Nystrom GJ, and Lang CH. Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity. Am J Physiol Endocrinol Metab, 2004.
286:E809-E817.
34. Geng Y, Zhang B, and Lotz M. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J Immunol, 1993. 151:6692-6700.
35. Gibson RM, Rothwell NJ, and Le Feuvre RA. CNS injury: the role of the cytokine IL-1. Vet J, 2004. 168:230-237.
36. Gorter JA, van Vliet EA, Aronica E, Breit T, Rauwerda H, Lopes da Silva FH, and Wadman WJ. Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci, 2006. 26:11083-11110.
37. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH, Jr., Heimovitz H, Cohen HJ, and Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med, 1999.
106:506-512.
38. Haspolat S, Mihci E, Coskun M, Gumuslu S, Ozben T, and Yegin O.
Interleukin-1beta, tumor necrosis factor-alpha, and nitrite levels in febrile seizures. J Child Neurol, 2002. 17:749-751.
39. Heida JG and Pittman QJ. Causal links between brain cytokines and experimental febrile convulsions in the rat. Epilepsia, 2005. 46:1906-1913.
40. Hulkkonen J, Koskikallio E, Rainesalo S, Keranen T, Hurme M, and Peltola J.
The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients. Epilepsy Res, 2004. 59:199-205.
41. Ichiyama T, Okada K, Lipton JM, Matsubara T, Hayashi T, and Furukawa S.
Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB. Brain Res, 2000. 857:246-251.
42. Jamali S, Bartolomei F, Robaglia-Schlupp A, Massacrier A, Peragut JC, Regis J, Dufour H, Ravid R, Roll P, Pereira S, Royer B, Roeckel-Trevisiol N, Fontaine M, Guye M, Boucraut J, Chauvel P, Cau P, and Szepetowski P.
Large-scale expression study of human mesial temporal lobe epilepsy:
evidence for dysregulation of the neurotransmission and complement systems in the entorhinal cortex. Brain, 2006. 129:625-641.
43. Juttler E, Tarabin V, and Schwaninger M. Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity. Neuroscientist, 2002. 8:268-275.
44. Kang JS, Yoon YD, Lee KH, Park SK, and Kim HM. Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. Biochem Biophys Res Commun, 2004.
313:171-177.
45. Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther, 2006. 8 Suppl 2:S2-
46. Koj A. Initiation of acute phase response and synthesis of cytokines. Biochim Biophys Acta, 1996. 1317:84-94.
47. Lehtimaki KA, Keranen T, Huhtala H, Hurme M, Ollikainen J, Honkaniemi J, Palmio J, and Peltola J. Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration. J Neuroimmunol, 2004. 152:121-125.
48. Lehtimaki KA, Keranen T, Palmio J, Makinen R, Hurme M, Honkaniemi J, and Peltola J. Increased plasma levels of cytokines after seizures in localization-related epilepsy. Acta Neurol Scand, 2007. 116:226-230.
49. Leoni F, Fossati G, Lewis EC, Lee JK, Porro G, Pagani P, Modena D, Moras ML, Pozzi P, Reznikov LL, Siegmund B, Fantuzzi G, Dinarello CA, and Mascagni P. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med, 2005. 11:1-15.
50. Li AJ, Katafuchi T, Oda S, Hori T, and Oomura Y. Interleukin-6 inhibits long-term potentiation in rat hippocampal slices. Brain Res, 1997. 748:30-38.
51. Lohrer P, Gloddek J, Nagashima AC, Korali Z, Hopfner U, Pereda MP, Arzt E, Stalla GK, and Renner U. Lipopolysaccharide directly stimulates the intrapituitary interleukin-6 production by folliculostellate cells via specific receptors and the p38alpha mitogen-activated protein kinase/nuclear factor-kappaB pathway. Endocrinology, 2000. 141:4457-4465.
52. Luders H, Acharya J, Baumgartner C, Benbadis S, Bleasel A, Burgess R, Dinner DS, Ebner A, Foldvary N, Geller E, Hamer H, Holthausen H, Kotagal P, Morris H, Meencke HJ, Noachtar S, Rosenow F, Sakamoto A, Steinhoff BJ, Tuxhorn I, and Wyllie E. Semiological seizure classification. Epilepsia, 1998.
39:1006-1013.
53. Manford M, Hart YM, Sander JW, and Shorvon SD. The National General Practice Study of Epilepsy. The syndromic classification of the International League Against Epilepsy applied to epilepsy in a general population. Arch Neurol, 1992. 49:801-808.
54. Marz P, Heese K, Dimitriades-Schmutz B, Rose-John S, and Otten U. Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia, 1999. 26:191-200.
55. McEachern JC and Shaw CA. The plasticity-pathology continuum: defining a role for the LTP phenomenon. J Neurosci Res, 1999. 58:42-61.
56. Meador KJ, Loring DW, Ray PG, Helman SW, Vazquez BR, and Neveu PJ.
Role of cerebral lateralization in control of immune processes in humans. Ann Neurol, 2004. 55:840-844.
57. Moller JC, Kruttgen A, Burmester R, Weis J, Oertel WH, and Shooter EM.
Release of interleukin-6 via the regulated secretory pathway in PC12 cells.
Neurosci Lett, 2006. 400:75-79.
58. Munoz-Fernandez MA and Fresno M. The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system. Prog Neurobiol, 1998.
56:307-340.
59. Neveu PJ. Cerebral lateralization and the immune system. Int Rev Neurobiol, 2002. 52:303-323.
60. Pacifici R, Paris L, Di Carlo S, Bacosi A, Pichini S, and Zuccaro P. Cytokine production in blood mononuclear cells from epileptic patients. Epilepsia, 1995.
36:384-387.
61. Peltola J, Hurme M, Miettinen A, and Keranen T. Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures. Epilepsy Res, 1998. 31:129-133.
62. Peltola J, Palmio J, Korhonen L, Suhonen J, Miettinen A, Hurme M, Lindholm D, and Keranen T. Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures. Epilepsy Res, 2000. 41:205-211.
63. Perneger TV. What's wrong with Bonferroni adjustments. BMJ, 1998.
316:1236-1238.
64. Romero LI, Kakucska I, Lechan RM, and Reichlin S. Interleukin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1 beta in rats. Am J Physiol, 1996. 270:R518-R524.
65. Rosenow F and Luders H. Presurgical evaluation of epilepsy. Brain, 2001.
124:1683-1700.
66. Sallmann S, Juttler E, Prinz S, Petersen N, Knopf U, Weiser T, and Schwaninger M. Induction of interleukin-6 by depolarization of neurons. J Neurosci, 2000. 20:8637-8642.
67. Sander JW. The epidemiology of epilepsy revisited. Curr Opin Neurol, 2003.
16:165-170.
68. Sano K and Kirino T. Ammon's horn sclerosis: its pathogenesis and clinical significance. Tohoku J Exp Med, 1990. 161 Suppl:273-295.
69. Scheller J and Rose-John S. Interleukin-6 and its receptor: from bench to bedside. Med Microbiol Immunol, 2006. 195:173-183.
70. Semah F, Picot MC, Adam C, Broglin D, Arzimanoglou A, Bazin B, Cavalcanti D, and Baulac M. Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology, 1998. 51:1256-1262.
71. Sharma AK, Reams RY, Jordan WH, Miller MA, Thacker HL, and Snyder PW.
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions. Toxicol Pathol, 2007. 35:984-999.
72. Sheng JG, Boop FA, Mrak RE, and Griffin WS. Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy:
association with interleukin-1 alpha immunoreactivity. J Neurochem, 1994.
63:1872-1879.
73. Sloviter RS. The neurobiology of temporal lobe epilepsy: too much information, not enough knowledge. C R Biol, 2005. 328:143-153.
74. Spangelo BL and Gorospe WC. Role of the cytokines in the neuroendocrine-immune system axis. Front Neuroendocrinol, 1995. 16:1-22.
75. Sperling MR and Guina L. The necessity for sphenoidal electrodes in the presurgical evaluation of temporal lobe epilepsy: pro position. J Clin Neurophysiol, 2003. 20:299-304.
76. Sriram K and O'Callaghan JP. Divergent roles for tumor necrosis factor-alpha in the brain. J Neuroimmune Pharmacol, 2007. 2:140-153.
77. Steffensen SC, Campbell IL, and Henriksen SJ. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res, 1994. 652:149-153.
78. Sun Y, Marz P, Otten U, Ge J, and Rose-John S. The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons. Biochem Biophys Res Commun, 2002. 295:532-539.
79. Tellez-Zenteno JF, Dhar R, and Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain, 2005. 128:1188-1198.
80. Terreni L and De Simoni MG. Role of the brain in interleukin-6 modulation.
Neuroimmunomodulation, 1998. 5:214-219.
81. Tilg H, Trehu E, Atkins MB, Dinarello CA, and Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood, 1994. 83:113-118.
82. Tomoum HY, Badawy NM, Mostafa AA, and Harb MY. Plasma interleukin-1beta levels in children with febrile seizures. J Child Neurol, 2007. 22:689-692.
83. Tomson T, Nashef L, and Ryvlin P. Sudden unexpected death in epilepsy:
current knowledge and future directions. Lancet Neurol, 2008. 7:1021-1031.
84. Tosi MF. Innate immune responses to infection. J Allergy Clin Immunol, 2005.
116:241-249.
85. Tutuncuoglu S, Kutukculer N, Kepe L, Coker C, Berdeli A, and Tekgul H.
Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions.
Pediatr Int, 2001. 43:235-239.
86. van Gassen KL, de Wit M, Koerkamp MJ, Rensen MG, van Rijen PC, Holstege FC, Lindhout D, and de Graan PN. Possible role of the innate immunity in temporal lobe epilepsy. Epilepsia, 2008. 49:1055-1065.
87. Van Wagoner NJ and Benveniste EN. Interleukin-6 expression and regulation in astrocytes. J Neuroimmunol, 1999. 100:124-139.
88. Verrotti A, Basciani F, Trotta D, Greco R, Morgese G, and Chiarelli F. Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1. Clin Exp Med, 2001. 1:133-136.
89. Vezzani A and Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia, 2005. 46:1724-1743.
90. Vgontzas AN, Bixler EO, Lin HM, Prolo P, Trakada G, and Chrousos GP. IL-6 and its circadian secretion in humans. Neuroimmunomodulation, 2005.
12:131-140.
91. Vincent P and Mulle C. Kainate receptors in epilepsy and excitotoxicity.
Neuroscience, 2009. 158:309-323.
92. Virta M, Hurme M, and Helminen M. Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia, 2002.
43:920-923.
93. Vitkovic L, Bockaert J, and Jacque C. "Inflammatory" cytokines:
neuromodulators in normal brain? J Neurochem, 2000. 74:457-471.
94. Wang CX and Shuaib A. Involvement of inflammatory cytokines in central nervous system injury. Prog Neurobiol, 2002. 67:161-172.
95. Yamamoto Y and Gaynor RB. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest, 2001. 107:135-142.
96. Yu Z, Zhou D, Bruce-Keller AJ, Kindy MS, and Mattson MP. Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury. J Neurosci, 1999. 19:8856-8865.
Lebenslauf
Vor- und Zuname: Sebastian Bauer
Geburtsdatum, -ort: 26. Juni 1978 in Wiesbaden Familienstand: ledig
Staatsangehörigkeit : deutsch
Anschrift Alter Kirchhainer Weg 29, 35039 Marburg
Schulausbildung:
1984 – 1988 Grundschule Zornheim
1988 – 1997 Rabanus-Maurus-Gymnasium Mainz 07/1997 Allgemeine Hochschulreife
Hochschulstudium:
1997 – 2000 Studium der Humanmedizin, Otto-von-Guericke- Universität Magdeburg
1999 Ärztliche Vorprüfung (Note „Gut“)
2000 1. Teil der Ärztlichen Prüfung (Note „Sehr Gut“)
2000 – 2004 Studium der Humanmedizin, Johann-Wolfgang-Goethe-Universität Frankfurt
2003 2. Teil der Ärztlichen Prüfung (Note „Sehr Gut“) 2004 3. Teil der Ärztlichen Prüfung (Note „Sehr Gut“) Gesamtnote der Ärztlichen Prüfung „Sehr Gut“
2004 Ärztliche Approbation
Beruflicher Werdegang:
seit 11/2004 Wissenschaftlicher Mitarbeiter der Klinik für Neurologie der Philipps-Universität Marburg, AG Epileptologie unter Leitung von Prof. Dr. F. Rosenow
Forschungsschwerpunkte 1. Epilepsie und unspezifisches Immunsystem 2. Automatische Anfallsdetektion und Closed-loop- Tiefenhirnstimulation zur Anfallsunterbrechung 3. Antiepileptika und Knochenstoffwechsel
4. Klinische Studien (Ausbildung als klinischer Monitor)
Publikationen
Zeitschriftenbeiträge
Rosenow F, Hamer HM, Bauer S. Valproat und Knochenstoffwechsel. Z Epileptol 2005 Aug;18(3):170–3.
Miller D, Knake S, Bauer S, Krakow K, Pagenstecher A, Sure U, Rosenow F.
Intraoperative ultrasound to define focal cortical dysplasia in epilepsy surgery.
Epilepsia. 2008 Jan;49(1):156-8.
Bauer S, Köller M, Cepok S, Todorova-Rudolph A, Nowak M, Nockher WA, Lorenz R, Tackenberg B, Oertel WH, Rosenow F, Hemmer B, Hamer HM. NK and CD4(+) T cell changes in blood after seizures in temporal lobe epilepsy. Exp Neurol. 2008 Feb 9.
Bauer S, Knake S, Haag A, Hermsen A, Strzelczyk A, Hamer HM, Rosenow F.
Seizures induced by the sight of moving water. Epileptic Disord. 2008 Mar;10(1):49-52.
Strzelczyk A, Bauer S, Knake S, Oertel WH, Hamer HM, Rosenow F. Ictal asystole in temporal lobe epilepsy before and after pacemaker implantation. Epileptic Disord.
2008 Mar;10(1):39-44.
Knake S, Gruener J, Hattemer K, Klein KM, Bauer S, Oertel WH, Hamer HM, Rosenow F. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2008 May;79(5):588-9.
Bauer S, Hamer HM. Stellenwert neuerer Antiepileptika in der Praxis. DNP Der Neurologe & Psychiater 07/2008, 45-49.
Bauer S, Cepok S, Todorova-Rudolph A, Nowak M, Köller M, Lorenz R, Oertel WH, Rosenow F, Hemmer B, Hamer HM. Etiology and site of temporal lobe epilepsy influence postictal cytokine release. Epilepsy Res. 2009 Sep;86(1):82-8.
Wehner T, Bauer S, Hamer HM, Hattemer K, Immisch I, Knake S, Nowak M, Reif PS, Strzelczyk A, Rosenow F. Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany. Epilepsy Behav. 2009 Nov;16(3):423-5
Strzelczyk A, Nowak M, Bauer S, Reif PS, Oertel WH, Knake S, Hamer HM, Rosenow F. Localizing and lateralizing value of ictal flatulence. Epilepsy Behav. 2010 Jan 9. [Epub ahead of print]
Bauer S, Rudd GD, Mylius V, Hamer HM, Rosenow F. Lacosamide intoxication in attempted suicide – A case report. Epilepsy and Behavior, in press.
Buchbeiträge
S. Bauer, H.M. Hamer, and F. Rosenow. Premotor and Central Lobe Epilepsy. in:
Textbook of Epilepsy Surgery (edited by H. Luders), Informa Healthcare, London 2008.
S. Bauer, H. Hamer. Schwerbehandelbare Epilepsie. In: Epilepsietherapie. UniMed-Verlag. Im Druck.
Preise
Video-Preis DGN 2007 Video-Preis DGN 2008 Dr.-Volker-Helbig-Preis 2008
Verzeichnis der akademischen Lehrer
Meine akademischen Lehrer waren die Damen/Herren
- in Magdeburg: Ansorge, Aurin, Becker, Fröhlich, Höllt, Hoffmann, Kasten, König, Läuter, Linke, Luley, Müller, Pape, Reiser, Robra, Röse, Roessner, Roskoden, Sabel, Schwarzberg, Schwegler, von Specht, Staak, Voigt, Wendler, Wolf, Zlatner
- in Frankfurt: Ackermann, Adili, Badenhoop, Bechstein, Böhles, Bratzke, Brodt, Caspary, Enke, Geiger, Geißlinger, Hansmann, Hermans, Hornung, Jonas, Kahles, M. Kaufmann, R. Kaufmann, Kempf, Kessler, Klingebiel, Kloes, Marzi, Maurer, Moritz, Ohrloff, Pession, Rickerts, Schmandra, Schmidt-Matthiesen, Schmitz-Rixen, Seifert, Sommerlad, Steinmetz, Wagner, Woeste, Zeuzem, Ziemann
- in Mainz: Atahi, Dillenburg, Dippold, Heintz, Junginger - in Zornheim: Endrulat, Kirsch.
9 Danksagung
Ich danke Herrn Professor Hamer sehr herzlich für die Betreuung und die kontinuierliche und vielfältige Unterstützung sowohl im Rahmen der Dissertation als auch in allen klinischen Fragen.
Herrn Professor Rosenow und allen Mitgliedern der Arbeitsgruppe Epileptologie danke ich für das angenehme Arbeitsklima und die konstruktive, offene Zusammenarbeit.
Ich danke Dr. Anelia Todorova-Rudolph und Mareike Nowak für die Unterstützung insbesondere in der Anfangsphase des Projektes.
Bei Jasmin Marczinski, Karina Wulf, Petra Müller, Kerstin Hallenberger, Daniela Siebert und Daniel Scholvien bedanke ich mich herzlich für die geduldige Hilfe bei der Blutentnahme während des Video-EEG-Monitorings.
Für zahlreiche aufschlussreiche Diskussionen der Ergebnisse und der Methodik sowie für ihre beständige Motivation danke ich Frau Dr. Anja Haag besonders herzlich.
Mein herzlichster Dank gilt meiner Mutter, die stets ein großer Rückhalt für mich ist und mir Ausbildung und Studium ermöglicht hat.