1. A. Abad, J. Victoria Fernandez-Molina, J. Bikandi, A. Ramirez, J. Margareto, J.
Sendino, H. F. Luis, J. Ponton, J. Garaizar, A. Rementeria (2010) What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. Rev Iberoam Micol 27:155-182
2. M. Abe, S. Ohmomo, T. Ohashi, T. Tabuchi (1969) Isolation of chanoclavine-(I) and two new interconvertible alkaloids, rugulovasine A and B, from the cultures of Penicillium concavo-rugulosum. Agri Biol Chem 33:469-471
3. W. R. Abraham, H. A. Arfmann (1992) Penicillium camemberti: a new source of brefeldin A. Planta Med 58:484
4. A. M. Amici, Minghetti.A, T. Scotti, C. Spalla, L. Tognoli (1966) Production of ergotamine by a strain of Claviceps purpurea (Fr.) Tul. Experientia 22:415-416
5. D. L. Arnold, P. M. Scott, P. F. McGuire, J. Harwig, E. A. Nera (1978) Acute toxicity studies on roquefortine and PR toxin, metabolites of Penicillium roqueforti, in the mouse. Food Cosmet Toxicol 16:369-371
6. S. L. Arnold, D. G. Panaccione (2017) Biosynthesis of the pharmaceutically important fungal ergot alkaloid dihydrolysergic acid requires a specialized allele of cloA. Appl Environ Microbiol 83:e00805-e00817
7. H. Auerbach, E. Oldenburg, F. Weissbach (1998) Incidence of Penicillium roqueforti and roquefortine C in silages. J Sci Food Agric 76:565-572
8. K. Backhaus, L. Ludwig-Radtke, X. Xie, S.-M. Li (2017) Manipulation of the precursor supply in yeast significantly enhances the accumulation of prenylated beta-carbolines.
ACS Synth Biol 6:1056-1064
9. G. T. Banks, P. G. Mantle, C. A. Szczyrbak (1974) Large-scale production of clavine alkaloids by Claviceps fusiformis. J Gen Microbiol 82:345-361
10. K. D. Barrow, F. R. Quigley (1975) Ergot alkaloids III: The isolation of N-methyl-4-dimethylallyltryptophan from claviceps fusiformis. Tetrahedron Lett 16:4269-4270
151 11. S. Bergmann, A. N. Funk, K. Scherlach, V. Schroeckh, E. Shelest, U. Horn, C.
Hertweck, A. A. Brakhage (2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76:8143-8149
12. Y. Bilovol, D. G. Panaccione (2016) Functional analysis of the gene controlling hydroxylation of festuclavine in the ergot alkaloid pathway of Neosartorya fumigata.
Curr Genet 62:853-860
13. C. Bond, Y. Tang, L. Li (2016) Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genet Biol 89:52-61
14. U. Bonuccelli, P. Del Dotto, O. Rascol (2009) Role of dopamine receptor agonists in the treatment of early Parkinson´s disease. Parkins Rel Disord 15S:S44-S53
15. A. A. Brakhage (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11:21-32
16. A. A. Brakhage, V. Schroeckh (2011) Fungal secondary metabolites - strategies to activate silent gene clusters. Fungal Genet Biol 48:15-22
17. Bruna, J. M., Hierro, E. M., de la Hoz, L., Mottram, D. S., Fernández, M., und Ordóñez, J. A. Changes in selected biochemical and sensory parameters as affected by the superficial inoculation of Penicillium camemberti on dry fermented sausages.
International Journal of Food Microbiology 85(1-2), 111-125. 15-8-2003.
18. K. Cheeseman, J. Ropars, P. Renault, J. Dupont, J. Gouzy, A. Branca, A. L. Abraham, M. Ceppi, E. Conseiller, R. Debuchy, F. Malagnac, A. Goarin, P. Silar, S. Lacoste, E.
Sallet, A. Bensimon, T. Giraud, Y. Brygoo (2014) Multiple recent horizontal transfers of a large genomic region in cheese making fungi. Nat Commun 5:2876
19. A. S. Chilton, A. L. Ellis, A. L. Lamb (2014) Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis. Acta Crystallogr F Struct Biol Commun 70:1328-1332
20. Ciegler A, Vesonder RF, Cole RJ (1976) Tremorgenic mycotoxins. In: Rodricks, J. V.
(ed) Adv. Chem. Vol 149: Mycotoxins and Other Fungal Related Food Problems. pp 163-177
152 21. R. J. Cole, J. W. Dorner, R. H. Cox, L. W. Raymond (1983) Two classes of alkaloid mycotoxins produced by Penicillium crustosum Thom isolated from contaminated beer.
J Agric Food Chem 31:655-657
22. R. J. Cole, J. W. Kirksey, J. W. Dorner, D. M. Wilson, J. Johnson, Jr., D. Bedell, J. P.
Springer, K. K. Chexal, J. Clardy, R. H. Cox (1977a) Mycotoxins produced by Aspergillus fumigatus isolated from silage. Ann Nutr Aliment 31:685-691
23. R. J. Cole, J. W. Kirksey, J. W. Dorner, D. M. Wilson, J. C. Johnson, Jr., A. N. Johnson, D. M. Bedell, J. P. Springer, K. K. Chexal, J. C. Clardy, R. H. Cox (1977b) Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage. J Agr Food Chem 25:826-830
24. Cole RJ, Schweikert MA (2003) Indole Alkaloids. In: Handbook of secondary fungal metabolites, Volume 1 edn. Elsevier Science, pp 1-143
25. M. P. Curran, C. M. Perry (2004) Cabergoline: a review of its use in the treatment of Parkinson's disease. Drugs 64:2125-2141
26. C. De Costa (2002) St Anthony's fire and living ligatures: a short history of ergometrine.
Lancet 359:1768-1770
27. L. S. de Medeiros, J. V. da Silva, L. M. Abreu, L. H. Pfenning, C. L. Silva, S. S. Thomasi, T. Venâncio, K. H. van Pée, K. F. Nielsen, E. Rodrigues-Filho (2015) Dichlorinated and brominated rugulovasines, ergot alkaloids produced by Talaromyces wortmannii.
Molecules 20:17627-17644
28. A. Del-Cid, C. Gil-Durán, I. Vaca, J. F. Rojas-Aedo, R. O. Garcia-Rico, G. Levicán, R.
Chávez (2016) Identification and functional analysis of the mycophenolic acid gene cluster of Penicillium roqueforti. PLoS One 11:e0147047
29. Dwivedi, B. K. und Kinsella, J. E. Continuous production of blue-type cheese flavour by submerged fermentation of Penicillium roqueforti. Journal of Food Science 39(3), 620-622. 1974.
30. A. Fernández-Bodega, R. Álvarez-Álvarez, P. Liras, J. F. Martin (2017) Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster. Appl Microbiol Biotechnol 101:6111-6121
153 31. D. J. Fleetwood, B. Scott, G. A. Lane, A. Tanaka, R. D. Johnson (2007) A complex ergovaline gene cluster in epichloe endophytes of grasses. Appl Environ Microbiol 73:2571-2579
32. M. Flieger, M. Wurst, R. Shelby (1997) Ergot alkaloids--sources, structures and analytical methods. Folia Microbiol (Praha) 42:3-30
33. H. G. Floss (1976) Biosynthesis of ergot alkaloids and related compounds. Tetrahedron 32:873-912
34. J. C. Frisvad, C. Rank, K. F. Nielsen, T. O. Larsen (2009) Metabolomics of Aspergillus fumigatus. Med Mycol 47:S53-S71
35. H. M. Ge, Z. G. Yu, J. Zhang, J. H. Wu, R. X. Tan (2009) Bioactive alkaloids from endophytic Aspergillus fumigatus. J Nat Prod 72:753-755
36. J. C. Gebler, C. D. Poulter (1992) Purification and characterization of dimethylallyl tryptophan synthase from Claviceps purpurea. Arch Biochem Biophys 296:308-313 37. N. Gerhards, M. Matuschek, C. Wallwey, S. M. Li (2015) Genome mining of
ascomycetous fungi reveals their genetic potential for ergot alkaloid production. Arch Microbiol 197:701-713
38. N. Gerhards, L. Neubauer, P. Tudzynski, S.-M. Li (2014) Biosynthetic pathways of ergot alkaloids. Toxins (Basel) 6:3281-3295
39. G. A. Glister, T. I. Williams (1944) Production of gliotoxin by Aspergillus fumigatus mut.
helvola Yuill. Nature 153:651
40. K. E. Goetz, C. M. Coyle, J. Z. Cheng, S. E. O'Connor, D. G. Panaccione (2011) Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus. Curr Genet 57:201-211
41. T. Görnemann, S. Jahnichen, B. Schurad, K. P. Latte, R. Horowski, J. Tack, M. Flieger, H. H. Pertz (2008) Pharmacological properties of a wide array of ergolines at functional alpha1-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 376:321-330 42. D. Gröger, H. G. Floss (1998) Biochemistry of ergot alkaloids - Achievements and
challenges . The Alkaloids, Chem Biol 50:171-218
154 43. U. Güldener, S. Heck, T. Fielder, J. Beinhauer, J. H. Hegemann (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 24:2519-2524
44. T. Haarmann, N. Lorenz, P. Tudzynski (2008) Use of a nonhomologous end joining deficient strain (Deltaku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis. Fungal Genet Biol 45:35-44
45. T. Haarmann, C. Machado, Y. Lübbe, T. Correia, C. L. Schardl, D. G. Panaccione, P.
Tudzynski (2005) The ergot alkaloid gene cluster in Claviceps purpurea: Extension of the cluster sequence and intra species evolution. Phytochemistry 66:1312-1320 46. T. Haarmann, Y. Rolke, S. Giesbert, P. Tudzynski (2009) Ergot: from witchcraft to
biotechnology. Mol Plant Pathol 10:563-577
47. J. Havemann, D. Vogel, B. Loll, U. Keller (2014) Cyclolization of D-lysergic acid alkaloid peptides. Chem Biol 21:146-155
48. Helen S.Toogood, John M.Gardiner, Nigel S.Scrutton (2010) Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases. ChemCatChem 2:892-914
49. Hofmann A (1993) LSD - Mein Sorgenkind. Deutscher Taschenbuch Verlag GmbH &
Co. KG, München
50. T. M. Hohl, M. Feldmesser (2007) Aspergillus fumigatus: Principles of pathogenesis and host defense. Eukaryot Cell 6:1953-1963
51. T. Iwase, A. Tajima, S. Sugimoto, K. Okuda, I. Hironaka, Y. Kamata, K. Takada, Y.
Mizunoe (2013) A simple assay for measuring catalase activity: a visual approach. Sci Rep 3:3081
52. A. P. Jacobus, J. Gross (2015) Optimal cloning of PCR fragments by homologous recombination in Escherichia coli. PLoS One 10:e0119221
53. D. Jakubczyk, L. Caputi, A. Hatsch, C. A. Nielsen, M. Diefenbacher, J. Klein, A. Molt, H. Schroder, J. Z. Cheng, M. Naesby, S. E. O'Connor (2015) Discovery and reconstitution of the cycloclavine biosynthetic pathway-enzymatic formation of a cyclopropyl group. Angew Chem Int Ed Engl 54:5117-5121
155 54. D. Jakubczyk, L. Caputi, C. E. Stevenson, D. M. Lawson, S. E. O'Connor (2016) Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chem Commun (Camb ) 52:14306-14309
55. J. M. Jez, J. L. Ferrer, M. E. Bowman, R. A. Dixon, J. P. Noel (2000) Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39:890-902
56. G. Jourdan, P. Verwaerde, A. Pathak, M. A. Tran, J. L. Montastruc, J. M. Senard (2007) In vivo pharmacodynamic interactions between two drugs used in orthostatic hypotension--midodrine and dihydroergotamine. Fundam Clin Pharmacol 21:45-53 57. J. D. Keasling (2012) Synthetic biology and the development of tools for metabolic
engineering. Metab Eng 14:189-195
58. U. K. Laemmli (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
59. J.-P. Latgé (1999) Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 12:310-350
60. J.-P. Latgé (2001) The pathobiology of Aspergillus fumigatus. Trends Microbiol 9:382-389
61. Law BA, Tamime AY (2010) Technology of cheesemaking. Wiley
62. J. Le Bars (1979) Cyclopiazonic acid production by Penicillium camemberti Thom and natural occurrence of this mycotoxin in cheese. Appl Environ Microbiol 38:1052-1055 63. S.-M. Li, I. A. Unsöld (2006) Post genome research on the biosynthesis of ergot
alkaloids. Planta Med 72:1117-1120
64. X. Liu, L. Wang, N. Steffan, W.-B. Yin, S.-M. Li (2009) Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B.
Chembiochem 10:2325-2328
65. N. Lorenz, T. Haarmann, S. Pazoutova, M. Jung, P. Tudzynski (2009) The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects. Phytochemistry 70:1822-1932
156 66. N. Lorenz, J. Olšovská, M. Šulc, P. Tudzynski (2010) The alkaloid cluster gene ccsA of the ergot fungus Claviceps purpurea encodes the chanoclavine-I-synthase, an FAD-containing oxidoreductase mediating the transformation of N-methyl-dimethylallyltryptophan to chanoclavine-I. Appl Environ Microbiol 76:1822-1830 67. N. Lorenz, E. V. Wilson, C. Machado, C. L. Schardl, P. Tudzynski (2007) Comparison
of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C. fusiformis. Appl Environ Microbiol 73:7185-7191 68. B. V. Lovell, M. J. Marmura (2010) New therapeutic developments in chronic migraine.
Curr Opin Neurol 23:254-258
69. P. Martinez-Martin, M. M. Kurtis (2009) Systematic review of the effect of dopamine receptor agonists on patient health-related quality of life. Parkinsonism Relat Disord 15 Suppl 4:S58-S64
70. M. Matuschek (2012) Molecular biological and biochemical investigations on the biosynthesis of mycotoxins from Ascomycetes. Dissertation Universität Marburg 71. M. Matuschek, C. Wallwey, B. Wollinsky, X. Xie, S.-M. Li (2012) In vitro conversion of
chanoclavine-I aldehyde to the stereoisomers festuclavine and pyroclavine controlled by the second reduction step. RSC Advances 2:3662-3669
72. M. Matuschek, C. Wallwey, X. Xie, S.-M. Li (2011) New insights into ergot alkaloid biosynthesis in Claviceps purpurea: an agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine. Org Biomol Chem 9:4328-4335
73. O. D. Monera, C. M. Kay, R. S. Hodges (1994) Protein denaturation with guanidine hydrochloride or urea provides a different estimate of stability depending on the contributions of electrostatic interactions. Protein Sci 3:1984-1991
74. C. Nielsen, C. Folly, A. Hatsch, A. Molt, H. Schroder, S. E. O'Connor, M. Naesby (2014) The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus. Microbial cell factories 13:1-11
157 75. W. C. Nierman, A. Pain, M. J. Anderson, J. R. Wortman, H. S. Kim, J. Arroyo, M.
Berriman, K. Abe, D. B. Archer, C. Bermejo, J. Bennett, P. Bowyer, D. Chen, M. Collins, R. Coulsen, R. Davies, P. S. Dyer, M. Farman, N. Fedorova, N. Fedorova, T. V.
Feldblyum, R. Fischer, N. Fosker, A. Fraser, J. L. Garcia, M. J. Garcia, A. Goble, G. H.
Goldman, K. Gomi, S. Griffith-Jones, R. Gwilliam, B. Haas, H. Haas, D. Harris, H.
Horiuchi, J. Huang, S. Humphray, J. Jimenez, N. Keller, H. Khouri, K. Kitamoto, T.
Kobayashi, S. Konzack, R. Kulkarni, T. Kumagai, A. Lafton, J. P. Latgèé, W. Li, A. Lord, C. Lu, W. H. Majoros, G. S. May, B. L. Miller, Y. Mohamoud, M. Molina, M. Monod, I.
Mouyna, S. Mulligan, L. Murphy, S. O'Neil, I. Paulsen, M. A. Penalva, M. Pertea, C.
Price, B. L. Pritchard, M. A. Quail, E. Rabbinowitsch, N. Rawlins, M. A. Rajandream, U. Reichard, H. Renauld, G. D. Robson, S. Rodriguez de Cordoba, J. M. Rodriguez-Pena, C. M. Ronning, S. Rutter, S. L. Salzberg, M. Sanchez, J. C. Sanchez-Ferrero, D.
Saunders, K. Seeger, R. Squares, S. Squares, M. Takeuchi, F. Tekaia, G. Turner, C.
R. Vazquez de Aldana, J. Weidman, O. White, J. Woodward, J. H. Yu, C. Fraser, J. E.
Galagan, K. Asai, M. Machida, N. Hall, B. Barrell, D. W. Denning (2005) Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
Nature 438:1151-1156
76. C. M. O'Gorman, H. Fuller, P. S. Dyer (2009) Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus. Nature 457:471-474
77. K. Ochi, T. Hosaka (2013) New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl Microbiol Biotechnol 97:87-98
78. S. Ohmomo, T. Sato, T. Utagawa, M. Abe (1975) Isolation of festuclavine and 3 new indole alkaloids, roquefortine-A, roquefortine-B and roquefortine-C from cultures of Penicillium roqueforti. Agric Biol Chem 39:1333-1334
79. S. Ohmomo, T. Utagawa, M. Abe (1977) Identification of roquefortine C produced by Penicillium roqueforti. Agric Biol Chem 41:2097-2098
80. I. Palmer, P. T. Wingfield (2004) Preparation and extraction of insoluble (inclusion-body) proteins from Escherichia coli. Curr Protoc Protein Sci Chapter 6:Unit
81. D. G. Panaccione, C. M. Coyle (2005) Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigatus. Appl Environ Microbiol 71:3106-3111
158 82. D. G. Panaccione, R. D. Johnson, J. Wang, C. A. Young, P. Damrongkool, B. Scott, C.
L. Schardl (2001) Elimination of ergovaline from a grass-Neotyphodium endophyte symbiosis by genetic modification of the endophyte. Proc Natl Acad Sci U S A 98:12820-12825
83. V. L. Perrin (1985) Clinical pharmacokinetics of ergotamine in migraine and cluster headache. Clin Pharmacokinet 10:334-352
84. L. Polonelli, G. Morace, R. Rosa, M. Castagnola, J. C. Frisvad (1987) Antigenic characterization of Penicillium camemberti and related common cheese contaminants.
Appl Environ Microbiol 53:872-878
85. P. V. Rajan, D. A. Wing (2010) Postpartum hemorrhage: Evidence-based medical interventions for prevention and treatment. Clin Obst Gyn 53:165-181
86. T. A. Reshetilova, N. G. Vinokurova, V. N. Khmelenina, A. G. Kozlovskii (1995) The role of roquefortine in the synthesis of alkaloids, meleagrine, glandicolines A and B, and oxaline in Penicillum glandicola and P. atramentosum. Mikrobiology (Moscow) 64:27-29
87. O. Rigbers, S.-M. Li (2008) Ergot alkaloid biosynthesis in Aspergillus fumigatus:
overproduction and biochemical characterisation of a 4-dimethylallyltryptophan N-methyltransferase. J Biol Chem 283:26859-26868
88. C. E. Robertson, D. F. Black, J. W. Swanson (2010) Management of migraine headache in the emergency department. Semin Neurol 30:201-211
89. S. L. Robinson, D. G. Panaccione (2014) Heterologous expression of lysergic acid and novel ergot alkaloids in Aspergillus fumigatus. Appl Environ Microbiol 80:6465-6472 90. S. L. Robinson, D. G. Panaccione (2015) Diversification of ergot alkaloids in natural
and modified fungi. Toxins 7:201-218
91. J. Ropars, J. Dupont, E. Fontanillas, Rodriguez de la Vega RC, F. Malagnac, M. Coton, T. Giraud, M. Lopez-Villavicencio (2012) Sex in cheese: evidence for sexuality in the fungus Penicillium roqueforti. PLoS One 7:e49665
92. P. J. Rutledge, G. L. Challis (2015) Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat Rev Microbiol 13:509-523
159 93. K. L. Ryan, C. T. Moore, D. G. Panaccione (2013) Partial reconstruction of the ergot alkaloid pathway by heterologous gene expression in Aspergillus nidulans. Toxins (Basel) 5:445-455
94. J. R. Saper, S. Silberstein (2006) Pharmacology of dihydroergotamine and evidence for efficacy and safety in migraine. Headache 46 Suppl 4:S171-S181
95. C. L. Schardl, S. Florea, J. Pan, P. Nagabhyru, S. Bec, P. J. Calie (2013a) The epichloae: alkaloid diversity and roles in symbiosis with grasses. Curr Opin Plant Biol 16:480-488
96. C. L. Schardl, D. G. Panaccione, P. Tudzynski (2006) Ergot alkaloids--biology and molecular biology. The Alkaloids, Chem Biol 63:45-86
97. C. L. Schardl, C. A. Young, J. Pan, S. Florea, J. E. Takach, D. G. Panaccione, M. L.
Farman, J. S. Webb, J. Jaromczyk, N. D. Charlton, P. Nagabhyru, L. Chen, C. Shi, A.
Leuchtmann (2013b) Currencies of mutualisms: sources of alkaloid genes in vertically transmitted epichloae. Toxins 5:1064-1088
98. C. L. Schardl, C. A. Young, U. Hesse, S. G. Amyotte, K. Andreeva, P. J. Calie, D. J.
Fleetwood, D. C. Haws, N. Moore, B. Oeser, D. G. Panaccione, K. K. Schweri, C. R.
Voisey, M. L. Farman, J. W. Jaromczyk, B. A. Roe, D. M. O'Sullivan, B. Scott, P.
Tudzynski, Z. An, E. G. Arnaoudova, C. T. Bullock, N. D. Charlton, L. Chen, M. Cox, R.
D. Dinkins, S. Florea, A. E. Glenn, A. Gordon, U. Guldener, D. R. Harris, W. Hollin, J.
Jaromczyk, R. D. Johnson, A. K. Khan, E. Leistner, A. Leuchtmann, C. Li, J. Liu, J. Liu, M. Liu, W. Mace, C. Machado, P. Nagabhyru, J. Pan, J. Schmid, K. Sugawara, U.
Steiner, J. E. Takach, E. Tanaka, J. S. Webb, E. V. Wilson, J. L. Wiseman, R. Yoshida, Z. Zeng (2013c) Plant-symbiotic fungi as chemical engineers: multi-genome analysis of the clavicipitaceae reveals dynamics of alkaloid loci. PLoS Genet 9:e1003323 99. P. L. Schiff (2006) Ergot and its alkaloids. Am J Pharma Edu 70:1-10
100. B. Schumann, D. Erge, W. Maier, D. Gröger (1982) A new strain of Claviceps purpurea accumulating tetracyclic clavine alkaloids. Planta Med 45:11-14
101. P. M. Scott, B. P. Kennedy, J. Harwig, B. J. Blanchfield (1977) Study of conditions of production of roquefortine and other metabolites of Penicillin roqueforti. Appl Environ Microbiol 33:249-253
102. P. M. Scott, B. P. C. Kennedy (1976) Analysis of blue cheese for roquefortine and other alkaloids from Penicillium roqueforti. J Agric Food Chem 24:865-868
160 103. I. Setnikar, K. Schmid, L. C. Rovati, B. Vens-Cappell, D. Mazur, I. Kozak (2001) Bioavailability and pharmacokinetic profile of dihydroergotoxine from a tablet and from an oral solution formulation. Arzneimittelforschung 51:2-6
104. R. D. Simoni, R. L. Hill, M. Vaughan (2002) Alkaloid Chemistry: the work of Walter A.
Jacobs. Journal of Biological Chemistry 277:547-551
105. J. F. Spilsbury, S. Wilkinson (1961) Isolation of festuclavine and two new clavine alkaloids from Aspergillus fumigatus. J Chem Soc 0:2085-2091
106. A. Stoll (1955) Introductory remarks on ergotamine. Int Arch Allergy Appl Immunol 7:197-204
107. J. R. Strickland, M. L. Looper, J. C. Matthews, C. F. Rosenkrans, Jr., M. D. Flythe, K.
R. Brown (2011) St. Anthony's Fire in livestock: Causes, mechanisms, and potential solutions. J Anim Sci 89:1603-1626
108. Studier, F. W. Protein production by auto-induction in high density shaking cultures.
Protein Expression and purification 41(1), 207-234. 12-3-2005.
109. R. Stuermer, B. Hauer, M. Hall, K. Faber (2007) Asymmetric bioreduction of activated C=C bonds using enoate reductases from the old yellow enzyme family. Curr Opin Chem Biol 11:203-213
110. S. Tarcz (2014) Molecular biological and biochemical investigatuions on prenyltransferases and NRPS-like enzymes from Ascomycetes. Dissertation Philipps-Universität Marburg
111. F. Tekaia, J.-P. Latgé (2005) Aspergillus fumigatus: saprophyte or pathogen? Curr Opin Microbiol 8:385-392
112. Thom, C. Fungi in cheese ripening: Camembert and roquefort. 82, 1-39. 1906.
Washington : U.S. Dept. of Agriculture, Bureau of Animal Industry. Bulletin / United States. Bureau of Animal Industry.
113. J. G. Thomas, F. Baneyx (1996) Protein misfolding and inclusion body formation in recombinant Escherichia coli cells overexpressing heat-shock proteins. Journal of Biological Chemistry 271:11141-11147
161 114. H. F. Tsai, H. Wang, J. C. Gebler, C. D. Poulter, C. L. Schardl (1995) The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis. Biochem Biophys Res Commun 216:119-125
115. H. Tscherter, H. Hauth (1974) Three new ergot alkaloids from saprophytic culture of Claviceps paspali Stevens et Hall. Helv Chim Acta 57:113-121
116. P. Tudzynski, K. Holter, T. Correia, C. Arntz, N. Grammel, U. Keller (1999) Evidence for an ergot alkaloid gene cluster in Claviceps purpurea. Mol Gen Genet 261:133-141 117. L.-R. Tulasne (1853) Mémoire sur l'ergot des glumacées. Ann Sci Nat 20:5-56
118. I. A. Unsöld (2006) Molecular biological and biochemical investigations on the biosynthesis of fumigaclavines in Aspergillus fumigatus AF 293 / B 5233 and Penicillium commune NRRL2033. Dissertation Universität Tübingen
119. I. A. Unsöld, S.-M. Li (2005) Overproduction, purification and characterization of FgaPT2, a dimethylallyltryptophan synthase from Aspergillus fumigatus. Microbiology 151:1499-1505
120. I. A. Unsöld, S.-M. Li (2006) Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification and characterization of fumigaclavine C synthase FgaPT1. Chembiochem 7:158-164 121. P. W. van Dongen, A. N. de Groot (1995) History of ergot alkaloids from ergotism to
ergometrine. Eur J Obstet Gynecol Reprod Biol 60:109-116
122. R. E. Wagener, N. D. Davis, U. L. Diener (1980) Penitrem A and roquefortine production by Penicillium commune. Appl Environ Microbiol 39:882-887
123. C. Wallwey, C. Heddergott, X. Xie, A. A. Brakhage, S.-M. Li (2012) Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology 158:1634-1644 124. C. Wallwey, S.-M. Li (2011) Ergot alkaloids: structure diversity, biosynthetic gene
clusters and functional proof of biosynthetic genes. Nat Prod Rep 28:496-510
125. C. Wallwey, M. Matuschek, S.-M. Li (2010a) Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH. Arch Microbiol 192:127-134
162 126. C. Wallwey, M. Matuschek, X.-L. Xie, S.-M. Li (2010b) Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Org Biomol Chem 8:3500-3508
127. J. Wenke, H. Anke, O. Sterner (1993) Pseurotin A and 8-O-demethylpseurotin A from Aspergillus fumigatus and their inhibitory activities on chitin synthase. Biosci Biotechnol Biochem 57:961-964
128. R. E. Williams, N. C. Bruce (2002) 'New uses for an Old Enzyme'--the Old Yellow Enzyme family of flavoenzymes. Microbiology 148:1607-1614
129. X. Xie, C. Wallwey, M. Matuschek, K. Steinbach, S.-M. Li (2011) Formyl migration product of chanoclavine-I aldehyde in the presence of the old yellow enzyme FgaOx3 from Aspergillus fumigatus: a NMR structure elucidation. Magn Reson Chem 49:678-681
130. J. Xu, Y. C. Song, Y. Guo, Y. N. Mei, R. X. Tan (2014) Fumigaclavines D-H, new ergot alkaloids from endophytic Aspergillus fumigatus. Planta Med 80:1131-1137
131. Y. Yamamoto, N. Kiriyama, S. Arahata (1968) Metabolic products of Aspergillus fumigatus J-4. Chemical structure of metabolic products. Chem Pharm Bull 16:304-310
132. M. Yamazaki, S. Suzuki, K. Miyaki (1971) Tremorgenic toxins from Aspergillus fumigatus. Chem Pharm Bull 19:1739-1740
133. H. Zhu, C. Chen, J. Wang, X. N. Li, G. Wei, Y. Guo, G. Yao, Z. Luo, J. Zhang, Y. Xue, Y. Zhang (2015) Penicamedine A, a highly oxygenated hexacyclic indole alkaloid from Penicillium camemberti. Chem Biodivers 12:1547-1553
163