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7. Literaturverzeichnis

Ananthan J, Goldberg AL, Voellmy R.

Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes.

Science. 1986 Apr 25;232(4749):522-4.

PMID: 3083508

Apolinario RM, van der Valk P, de Jong JS, Deville W, van Ark-Otte J, Dingemans AM, van Mourik JC, Postmus PE, Pinedo HM, Giaccone G.

Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer.

J Clin Oncol. 1997 Jun;15(6):2456-66.

PMID: 9196162

Arts HJ, Hollema H, Lemstra W, Willemse PH, De Vries EG, Kampinga HH, Van der Zee AG.

Heat-shock-protein-27 (hsp27) expression in ovarian carcinoma: relation in response to chemotherapy and prognosis.

Int J Cancer. 1999 Jun 21;84(3):234-8.

PMID: 10371339

Bakhshi A, Jensen JP, Goldman P, Wright JJ, McBride OW, Epstein AL, Korsmeyer SJ.

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

Cell. 1985 Jul;41(3):899-906.

PMID: 3924412 Baur X, Konietzko N.

[Environmental and occupational diseases]

Pneumologie. 1996 Sep;50 Suppl 2:604-6 PMID: 9157425

Becker N., Wahrendorf J.

Atlas of the cancer mortality in the Federal Republic of Germany 1981-1990 , 3rd Edition

Springer-Verlag, Berlin, Heidelberg (1997)

Borner MM, Brousset P, Pfanner-Meyer B, Bacchi M, Vonlanthen S, Hotz MA, Altermatt HJ, Schlaifer D, Reed JC, Betticher DC.

Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer.

Br J Cancer. 1999 Feb;79(5-6):952-8.

PMID: 10070896

Botzler C, Issels R, Multhoff G.

Heat-shock protein 72 cell-surface expression on human lung carcinoma cells in associated with an increased sensitivity to lysis mediated by adherent natural killer cells.

Cancer Immunol Immunother. 1996 Dec;43(4):226-30.

PMID: 9003468

Brabender J, Danenberg KD, Metzger R, Schneider PM, Park J, Salonga D, Holscher AH, Danenberg PV.

Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.

Clin Cancer Res. 2001 Jul;7(7):1850-5.

PMID: 11448895

Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T.

Retinoblastoma protein recruits histone deacetylase to repress transcription.

Nature. 1998 Feb 5;391(6667):597-601.

PMID: 9468139

Bronner MP, Culin C, Reed JC, Furth EE.

The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model.

Am J Pathol. 1995 Jan;146(1):20-6.

PMID: 7856728

Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N.

Induction of the growth inhibitor IGF-binding protein 3 by p53.

Nature. 1995 Oct 19;377(6550):646-9.

PMID: 7566179 Bukau B, Horwich AL.

The Hsp70 and Hsp60 chaperone machines.

Cell. 1998 Feb 6;92(3):351-66 PMID: 9476895

Capewell S, Sankaran R, Lamb D, McIntyre M, Sudlow MF.

Lung cancer in lifelong non-smokers. Edinburgh Lung Cancer Group.

Thorax. 1991 Aug;46(8):565-8.

PMID: 1656541 Carbone DP.

The biology of lung cancer.

Semin Oncol. 1997 Aug;24(4):388-401 PMID: 9280218

Cheng MY, Hartl FU, Martin J, Pollock RA, Kalousek F, Neupert W, Hallberg EM, Hallberg RL, Horwich AL.

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria.

Nature. 1989 Feb 16;337(6208):620-5.

PMID: 2645524

Chen-Levy Z, Nourse J, Cleary ML.

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

Mol Cell Biol. 1989 Feb;9(2):701-10.

PMID: 2651903

Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SA.

Biological and clinical implications of heat shock protein 27,000 (Hsp27):

J Natl Cancer Inst. 1993 Oct 6;85(19):1558-70 PMID: 8411230

Cox G, Walker RA, Muller S, Abrams KR, Steward WP, O'Byrne KJ.

Does immunointensity account for the differences in prognostic significance of Bcl-2 expression in non-small cell lung cancer?

Pathol Oncol Res. 2000;6(2):87-92.

PMID: 10938137

Dalquen P, Sauter G, Torhorst J, Schultheiss E, Jordan P, Lehmann S, Soler M, Stulz P, Mihatsch MJ, Gudat F.

Nuclear p53 overexpression is an independent prognostic parameter in node-negative non-small cell lung carcinoma.

J Pathol. 1996 Jan;178(1):53-8 PMID: 8778317

Denson KW.

Re: Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe.

J Natl Cancer Inst. 1999 May 5;91(9):803-4 PMID: 10328113

De Potter CR, Quatacker J.

The p185erbB2 protein is localized on cell organelles involved in cell motility.

Clin Exp Metastasis. 1993 Nov;11(6):453-61.

PMID: 7900945

Diez M, Pollan M, Maestro M, Torres A, Ortega D, Gomez A, Sanchez A, Hernando F, Balibrea JL.

Prediction of recurrence by quantification of p185neu protein in non-small-cell lung cancer tissue.

Br J Cancer. 1997;75(5):684-9.

PMID: 9043025

Dosaka-Akita H, Katabami M, Hommura H, Fujioka Y, Katoh H, Kawakami Y.

Bcl-2 expression in non-small cell lung cancers: higher frequency of expression in squamous cell carcinomas with earlier pT status.

Oncology. 1999 Apr;56(3):259-64.

PMID: 10202283

Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD.

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

Nature. 1984 Feb 9-15;307(5951):521-7.

PMID: 6320011

Dragovich T, Rudin CM, Thompson CB.

Signal transduction pathways that regulate cell survival and cell death.

Oncogene. 1998 Dec 24;17(25):3207-13 PMID: 9916983

Efferth T, Schulten HG, Thelen P, Bode ME, Beniers AJ, Granzen B, Ringert RH, Mertens R, Gefeller O, Jakse G, Fuzesi L.

Differential expression of the heat shock protein 70 in the histological compartments of nephroblastomas.

Anticancer Res. 2001 Jul-Aug;21(4B):2915-20.

PMID: 11712786

Fortin A, Raybaud-Diogene H, Tetu B, Deschenes R, Huot J, Landry J.

Overexpression of the 27 KDa heat shock protein is associated with thermoresistance and chemoresistance but not with radioresistance.

Int J Radiat Oncol Biol Phys. 2000 Mar 15;46(5):1259-66.

PMID: 10725639

Gething MJ, Sambrook J.

Protein folding in the cell.

Nature. 1992 Jan 2;355(6355):33-45 PMID: 1731198

Greenblatt MS, Bennett WP, Hollstein M, Harris CC.

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Cancer Res. 1994 Sep 15;54(18):4855-78 PMID: 8069852

F. Grossi, M. Loprevite, M. Chiaramondia, P. Ceppa, C. Pera, G.B. Ferrara, G.B.

Ratto, J. Serrano, L. Boni, A. Ardizzoni

Prognostic Significance of k-ras, p53, bcl-2, PCNA, CD34 in radically resected NSCLC: An analysis of 269 patients

-noch nicht veröffentlichte

Arbeit-Häußinger K.E., Kohlhäufl M.

Tumorzentrum München an den Medizinischen Fakultäten der Ludwig-Maximilians-Universität und derTechnischen Ludwig-Maximilians-Universität (Hrsg.):

Tumoren der Lunge und des Mediastinums; Empfehlungen zur Diagnostik,Therapie und Nachsorge; Tumorzentrum München; 4. Auflage;1997

Han H, Landreneau RJ, Santucci TS, Tung MY, Macherey RS, Shackney SE, Sturgis CD, Raab SS, Silverman JF.

Prognostic value of immunohistochemical expressions of p53, HER-2/neu, and bcl-2 in stage I non-small-cell lung cancer.

Hum Pathol. 2002 Jan;33(1):105-10.

PMID: 11823980

Harris JR, Lippman ME, Veronesi U, Willett W.

Breast cancer (3).

N Engl J Med. 1992 Aug 13;327(7):473-80 PMID: 1625737

Hartman DJ, Hoogenraad NJ, Condron R, Hoj PB.

Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro.

Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3394-8.

PMID: 1348860

Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M.

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

Genes Dev. 1995 Sep 1;9(17):2170-83.

PMID: 7657168

Haussinger K, Huber RM.

[Bronchial carcinoma (lung cancer)]

Pneumologie. 1996 Sep;50 Suppl 2:599-603 PMID: 9157424

Hengstschlager M, Braun K, Soucek T, Miloloza A, Hengstschlager-Ottnad E.

Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle.

Mutat Res. 1999 Jan;436(1):1-9 PMID: 9878675

Hightower LE.

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides.

J Cell Physiol. 1980 Mar;102(3):407-27.

PMID: 6901532 Hillerdal G.

Pleural plaques and risk for bronchial carcinoma and mesothelioma. A prospective study.

Chest. 1994 Jan;105(1):144-50.

PMID: 8275722

Hirsch FR, Varella-Garcia M, Franklin WA, Veve R, Chen L, Helfrich B, Zeng C, Baron A, Bunn PA Jr.

Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas.

Br J Cancer. 2002 May 6;86(9):1449-56.

PMID: 11986780

Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ.

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

Nature. 1990 Nov 22;348(6299):334-6.

PMID: 2250705

Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ.

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):6961-5.

PMID: 1871110

Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ.

Bcl-2 functions in an antioxidant pathway to prevent apoptosis.

Cell. 1993 Oct 22;75(2):241-51.

PMID: 7503812

Hollstein M, Sidransky D, Vogelstein B, Harris CC.

p53 mutations in human cancers.

Science. 1991 Jul 5;253(5015):49-53 PMID: 1905840

Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW, Yansura D, Abadi N, Raab H, Lewis GD, et al.

Identification of heregulin, a specific activator of p185erbB2.

Science. 1992 May 22;256(5060):1205-10.

PMID: 1350381

Hueber AO, Zornig M, Lyon D, Suda T, Nagata S, Evan GI.

Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis.

Science. 1997 Nov 14;278(5341):1305-9.

PMID: 9360929 Hunter T.

Oncoprotein networks.

Cell. 1997 Feb 7;88(3):333-46 PMID: 9039260

Jaattela M, Wissing D, Kokholm K, Kallunki T, Egeblad M.

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

EMBO J. 1998 Nov 2;17(21):6124-34.

PMID: 9799222

Jones DB, Coulson AF, Duff GW.

Sequence homologies between hsp60 and autoantigens.

Immunol Today. 1993 Mar;14(3):115-8 PMID: 8466626

Karre K.

MHC gene control of the natural killer system at the level of the target and the host.

Semin Cancer Biol. 1991 Oct;2(5):295-309.

PMID: 1773046

Khuri FR, Kurie JM, Hong WK.

Chemoprevention of respiratory tract cancer.

Hematol Oncol Clin North Am. 1997 Jun;11(3):387-408 PMID: 9209902

Kiang JG, Carr FE, Burns MR, McClain DE.

HSP-72 synthesis is promoted by increase in [Ca2+]i or activation of G proteins but not pHi or cAMP.

Am J Physiol. 1994 Jul;267(1 Pt 1):C104-14.

PMID: 8048473

Kim YC, Park KO, Kern JA, Park CS, Lim SC, Jang AS, Yang JB.

The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients.

Lung Cancer. 1998 Dec;22(3):181-90.

PMID: 10048471

King KL, Li AF, Chau GY, Chi CW, Wu CW, Huang CL, Lui WY.

Prognostic significance of heat shock protein-27 expression in hepatocellular carcinoma and its relation to histologic grading and survival.

Cancer. 2000 Jun 1;88(11):2464-70.

PMID: 10861421

Kinzler KW, Vogelstein B.

Lessons from hereditary colorectal cancer.

Cell. 1996 Oct 18;87(2):159-70 PMID: 8861899

Kinzler KW, Vogelstein B.

Cancer-susceptibility genes. Gatekeepers and caretakers.

Nature. 1997 Apr 24;386(6627):761, 763 PMID: 9126728

Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD.

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.

Science. 1997 Feb 21;275(5303):1132-6.

PMID: 9027315

Knudson AG Jr.

Hereditary cancer, oncogenes, and antioncogenes.

Cancer Res. 1985 Apr;45(4):1437-43 PMID: 2983882

Koomagi R, Stammler G, Manegold C, Mattern J, Volm M.

Expression of resistance-related proteins in tumoral and peritumoral tissues of patients with lung cancer.

Cancer Lett. 1996 Dec 20;110(1-2):129-36.

PMID: 9018091 Korsmeyer SJ.

Bcl-2 initiates a new category of oncogenes: regulators of cell death.

Blood. 1992 Aug 15;80(4):879-86 PMID: 1498330

Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Cox J, Krammer B, Gatter KC, Harris AL.

bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer.

Clin Exp Metastasis. 1999;17(7):545-54.

PMID: 10845553

Kristiansen G, Yu Y, Petersen S, Kaufmann O, Schluns K, Dietel M, Petersen I.

Overexpression of c-erbB2 protein correlates with disease-stage and chromosomal gain at the c-erbB2 locus in non-small cell lung cancer.

Eur J Cancer. 2001 Jun;37(9):1089-95.

PMID: 11378338

Laudanski J, Chyczewski L, Niklinska WE, Kretowska M, Furman M, Sawicki B, Niklinski J.

Expression of bcl-2 protein in non-small cell lung cancer: correlation with clinicopathology and patient survival.

Neoplasma. 1999;46(1):25-30.

PMID: 10355530

Laudanski J, Niklinska W, Burzykowski T, Chyczewski L, Niklinski J.

Prognostic significance of p53 and bcl-2 abnormalities in operable nonsmall cell lung cancer.

Eur Respir J. 2001 Apr;17(4):660-6.

PMID: 11401061

Lazaris AC, Theodoropoulos GE, Davaris PS, Panoussopoulos D, Nakopoulou L, Kittas C, Golematis BC.

Heat shock protein 70 and HLA-DR molecules tissue expression. Prognostic implications in colorectal cancer.

Dis Colon Rectum. 1995 Jul;38(7):739-45.

PMID: 7607036

Lazaris ACh, Chatzigianni EB, Panoussopoulos D, Tzimas GN, Davaris PS, Golematis BCh.

Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified.

Breast Cancer Res Treat. 1997 Mar;43(1):43-51.

PMID: 9065598

Lee JS, Yoon A, Kalapurakal SK, Ro JY, Lee JJ, Tu N, Hittelman WN, Hong WK.

Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor.

J Clin Oncol. 1995 Aug;13(8):1893-903.

PMID: 7636531 Levine AJ.

p53, the cellular gatekeeper for growth and division.

Cell. 1997 Feb 7;88(3):323-31 PMID: 9039259

Lopez-Guerrero JA, Bolufer-Gilabert P, Vera-Sempere FJ, Marugan de la Concha I, Barragan-Gonzalez E.

C-erbB-2 expression and its relationship with ploidy, p53 abnormalities and epidermal growth factor receptor content in human non-small cell lung cancer.

Clin Chim Acta. 1999 Jul;285(1-2):105-20.

PMID: 10481927

Lu QL, Poulsom R, Wong L, Hanby AM.

Bcl-2 expression in adult and embryonic non-haematopoietic tissues.

J Pathol. 1993 Apr;169(4):431-7.

PMID: 8501540

Lupu R, Colomer R, Zugmaier G, Sarup J, Shepard M, Slamon D, Lippman ME.

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

Science. 1990 Sep 28;249(4976):1552-5.

PMID: 2218496

Mairesse N, Horman S, Mosselmans R, Galand P.

Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cells.

Cell Biol Int. 1996 Mar;20(3):205-12.

PMID: 8673069

Malusecka E, Zborek A, Krzyzowska-Gruca S, Krawczyk Z.

Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study.

Anticancer Res. 2001 Mar-Apr;21(2A):1015-21.

PMID: 11396134

McKay DB.

Structure and mechanism of 70-kDa heat-shock-related proteins.

Adv Protein Chem. 1993;44:67-98 PMID: 8317298

Mehlen P, Kretz-Remy C, Preville X, Arrigo AP.

Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

EMBO J. 1996 Jun 3;15(11):2695-706.

PMID: 8654367

Mivechi NF, Murai T, Hahn GM.

Inhibitors of tyrosine and Ser/Thr phosphatases modulate the heat shock response.

J Cell Biochem. 1994 Feb;54(2):186-97.

PMID: 8175893 Muller KM, Theile A.

[Lung tumors. Pathologic-anatomic diagnosis]

Internist (Berl). 1994 Aug;35(8):710-23 PMID: 7960551

Neidhardt FC, VanBogelen RA, Vaughn V.

The genetics and regulation of heat-shock proteins.

Annu Rev Genet. 1984;18:295-329 PMID: 6442118

Noguchi T, Takeno S, Shibata T, Uchida Y, Yokoyama S, Muller W.

Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.

Ann Thorac Surg. 2002 Jul;74(1):222-6.

PMID: 12118763

Oesterreich S, Weng CN, Qiu M, Hilsenbeck SG, Osborne CK, Fuqua SA.

The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines.

Cancer Res. 1993 Oct 1;53(19):4443-8.

PMID: 8402609

Ohsaki Y, Toyoshima E, Fujiuchi S, Matsui H, Hirata S, Miyokawa N, Kubo Y, Kikuchi K.

bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time.

Clin Cancer Res. 1996 May;2(5):915-20.

PMID: 9816250

Passlick B, Izbicki JR, Riethmuller G, Pantel K.

p53 in non-small-cell lung cancer.

J Natl Cancer Inst. 1994 May 18;86(10):801-3 PMID: 8169981

Preville X, Salvemini F, Giraud S, Chaufour S, Paul C, Stepien G, Ursini MV, Arrigo AP.

Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery.

Exp Cell Res. 1999 Feb 25;247(1):61-78.

PMID: 10047448

Prisco M, Hongo A, Rizzo MG, Sacchi A, Baserga R.

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

Mol Cell Biol. 1997 Mar;17(3):1084-92.

PMID: 9032235

Raybaud-Diogene H, Tetu B, Morency R, Fortin A, Monteil RA.

p53 overexpression in head and neck squamous cell carcinoma: review of the literature.

Eur J Cancer B Oral Oncol. 1996 May;32B(3):143-9 PMID: 8762869

Reinmuth N, Brandt B, Kunze WP, Junker K, Thomas M, Achatzy R, Scheld HH, Semik M.

Ploidy, expression of erbB1, erbB2, P53 and amplification of erbB1, erbB2 and erbB3 in non-small cell lung cancer.

Eur Respir J. 2000 Nov;16(5):991-6.

PMID: 11153605

Ricaniadis N, Kataki A, Agnantis N, Androulakis G, Karakousis CP.

Long-term prognostic significance of HSP-70, c-myc and HLA-DR expression in patients with malignant melanoma.

Eur J Surg Oncol. 2001 Feb;27(1):88-93.

PMID: 11237497

Ritter JH, Dresler CM, Wick MR.

Expression of bcl-2 protein in stage T1N0M0 non-small cell lung carcinoma.

Hum Pathol. 1995 Nov;26(11):1227-32.

PMID: 7590697

Robert J, Gantress J, Rau L, Bell A, Cohen N.

Minor histocompatibility antigen-specific MHC-restricted CD8 T cell responses elicited by heat shock proteins.

J Immunol. 2002 Feb 15;168(4):1697-703.

PMID: 11823499

Rosler JA, Woitowitz HJ.

Recent data on cancer due to asbestos in Germany.

Med Lav. 1995 Sep-Oct;86(5):440-8.

PMID: 8684294

Rosse T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C.

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c.

Nature. 1998 Jan 29;391(6666):496-9.

PMID: 9461218

Ruggeri B, DiRado M, Zhang SY, Bauer B, Goodrow T, Klein-Szanto AJ.

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.

Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1013-7.

PMID: 8430068 Samet JM.

The epidemiology of lung cancer.

Chest. 1993 Jan;103(1 Suppl):20S-29S.

PMID: 8416770

Scheurle D, Jahanzeb M, Aronsohn RS, Watzek L, Narayanan R.

HER-2/neu expression in archival non-small cell lung carcinomas using FDA-approved Hercep test.

Anticancer Res. 2000 May-Jun;20(3B):2091-6.

PMID: 10928158

Schiller JH, Adak S, Feins RH, Keller SM, Fry WA, Livingston RB, Hammond ME, Wolf B, Sabatini L, Jett J, Kohman L, Johnson DH.

Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern

Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy.

J Clin Oncol. 2001 Jan 15;19(2):448-57.

PMID: 11208838 [

Schneider E, Montenarh M, Wagner P.

Regulation of CAK kinase activity by p53.

Oncogene. 1998 Nov 26;17(21):2733-41.

PMID: 9840937

Schneider J, Jimenez E, Marenbach K, Romero H, Marx D, Meden H.

Immunohistochemical detection of HSP60-expression in human ovarian cancer.

Correlation with survival in a series of 247 patients.

Anticancer Res. 1999 May-Jun;19(3A):2141-6.

PMID: 10470162

Shiseki M, Kohno T, Nishikawa R, Sameshima Y, Mizoguchi H, Yokota J.

Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma.

Cancer Res. 1994 Nov 1;54(21):5643-8.

PMID: 7923210

Shopland DR, Pechacek TF, Cullen JW.

Toward a tobacco-free society.

Semin Oncol. 1990 Aug;17(4):402-12 PMID: 2201086

Srivastava PK.

Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation.

Adv Cancer Res. 1993;62:153-77 PMID: 8109317

Srivastava PK, Udono H, Blachere NE, Li Z.

Heat shock proteins transfer peptides during antigen processing and CTL priming.

Immunogenetics. 1994;39(2):93-8 PMID: 8276462

Statistische Bundesamt Deutschland 2002

http://www.destatis.de/basis/d/gesu/gesutab3.htm Statistische Bundesamt Deutschland 2002

http://www.destatis.de/presse/deutsch/pm2001/p3840092.htm Subjeck JR, Shyy TT.

Stress protein systems of mammalian cells.

Am J Physiol. 1986 Jan;250(1 Pt 1):C1-17 PMID: 3510555

Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G.

Molecular characterization of mitochondrial apoptosis-inducing factor.

Nature. 1999 Feb 4;397(6718):441-6.

PMID: 9989411

Tammemagi MC, McLaughlin JR, Mullen JB, Bull SB, Johnston MR, Tsao MS, Casson AG.

A study of smoking, p53 tumor suppressor gene alterations and non-small cell lung cancer.

Ann Epidemiol. 2000 Apr;10(3):176-85.

PMID: 10813511

Tamura Y, Tsuboi N, Sato N, Kikuchi K.

70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity.

J Immunol. 1993 Nov 15;151(10):5516-24.

PMID: 8228242

Tonato M., on behalf of the ALPI/EORTC-LCG investigators, Policlinico Hospital, Perugia, Italy

Final report of the Adjuvant Lung Project Italy (ALPI): an Italian/EORTC-LCG

randomised trial of adjuvant chemotherapy in completely resected non-small cell lung cancer (NSCLC).

ASCO Year: 2002 Abstract No: 1157 Category: Non-Small-Cell Lung Cancer Tsuchiya E, Nakamura Y, Weng SY, Nakagawa K, Tsuchiya S, Sugano H, Kitagawa T.

Allelotype of non-small cell lung carcinoma--comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma.

Cancer Res. 1992 May 1;52(9):2478-81.

PMID: 1314694

Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM.

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.

Science. 1984 Nov 30;226(4678):1097-9.

PMID: 6093263

Udono H, Srivastava PK.

Heat shock protein 70-associated peptides elicit specific cancer immunity.

J Exp Med. 1993 Oct 1;178(4):1391-6.

PMID: 8376942

Vaux DL, Aguila HL, Weissman IL.

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.

Int Immunol. 1992 Jul;4(7):821-4.

PMID: 1498090

Vega FJ, Iniesta P, Caldes T, Sanchez A, Lopez JA, de Juan C, Diaz-Rubio E, Torres A, Balibrea JL, Benito M.

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer.

Br J Cancer. 1997;76(1):44-51.

PMID: 9218731

Vilaboa NE, Galan A, Troyano A, de Blas E, Aller P.

Regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1).

J Biol Chem. 2000 Aug 11;275(32):24970-6.

PMID: 10816597

Volm M, Mattern J, Stammler G.

Up-regulation of heat shock protein 70 in adenocarcinomas of the lung in smokers.

Anticancer Res. 1995 Nov-Dec;15(6B):2607-9.

PMID: 8669833

Warri AM, Laine AM, Majasuo KE, Alitalo KK, Harkonen PL.

Estrogen suppression of erbB2 expression is associated with increased growth rate of ZR-75-1 human breast cancer cells in vitro and in nude mice.

Int J Cancer. 1991 Oct 21;49(4):616-23.

PMID: 1680817 Watson K.

Microbial stress proteins.

Adv Microb Physiol. 1990;31:183-223 PMID: 2264523

Welch WJ.

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease.

Physiol Rev. 1992 Oct;72(4):1063-81 PMID: 1438579

Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC.

Early age at smoking initiation and tobacco carcinogen DNA damage in the lung.

J Natl Cancer Inst. 1999 Apr 7;91(7):614-9.

PMID: 10203280

Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y.

Heat shock protein 27 was up-regulated in cisplatin resistant human ovarian tumor cell line and associated with the cisplatin resistance.

Cancer Lett. 2001 Jul 26;168(2):173-81.

PMID: 11403922

Yang E, Korsmeyer SJ.

Molecular thanatopsis: a discourse on the BCL2 family and cell death.

Blood. 1996 Jul 15;88(2):386-401 PMID: 8695785

Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X.

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.

Science. 1997 Feb 21;275(5303):1129-32.

PMID: 9027314

Yoshino I, Goedegebuure PS, Peoples GE, Lee KY, Eberlein TJ.

Human tumor-infiltrating CD4+ T cells react to B cell lines expressing heat shock protein 70.

J Immunol. 1994 Nov 1;153(9):4149-58.

PMID: 7930618 Yu DH, Hung MC.

Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells.

Oncogene. 1991 Nov;6(11):1991-6.

PMID: 1682865