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1. Ananthaswamy HN, Pierceall WE (1990): Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol 52, 119-1136

2. Annett K, Hyland P, Duggan O, Barnett C, Barnett Y (2004): An investigation of DNA excision repair capacity in human CD4+ T cell clones as a function of age in vitro. Exp Gerontol 39, 491-498

3. Armstrong BK, Kricker A (1995): Skin cancer. Dermatol Clin 13, 583-594 4. Autier P, Joarlette M, Lejeune F, Lienard D, Andre J, Achten G (1991):

Cutaneous malignant melanoma and exposure to sunlamps and sunbeds: a descriptive study in Belgium. Melanoma Res 1, 69-74

5. Baccarelli A, Calista D, Minghetti P, Marinelli B, Albetti B, Tseng T, Hedayati M, Grossman L, Landi G, Struewing JP, Landi MT (2004): XPD gene polymorphism and host characteristics in the association with cutaneous malignant melanoma risk. Br J Cancer 90, 497-502

6. Berwick M, Vineis P (2000): Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst 92, 874-897

7. Boddie AW Jr., McBride CM: Das Melanom bei Kindern und Jugendlichen; in:

Hautmelanome Diagnose, Therapie und weltweite Ergebnisse; hrsg. v. Balch CM, Milton GW, Shaw HM, Soong SJ;. Springer Verlag, Berlin 1988, 67-73 8. Boiteux S, Radicella JP (1999): Base excision repair of 8-hydroxyguanine

protects DNA from endogenous oxidative stress. Biochimie 81, 59-67

9. Bootsma D, Kraemer KH, Cleaver JE, Hoeijmakers JH: Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrom, and trichodthiodystrophy; in: The Genetic Basis of Human Cancer; hrsg. v.

Vogelstein B, Kinzler KW; McGraw-Hill, NewYork: 2002, 211-237

10. Brett D, Hanke J, Lehmann G, Haase S, Delbruck S, Krueger S, Reich J, Bork P (2000): EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. FEBS Lett 474, 83-86

11. Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NG, Fawcett H, Raams A, Garritsen VH, Stary A, Avril MF, Boudsocq F, Masutani C, Hanaoka F, Fuchs RP, Sarasin A, Lehmann AR (2002): Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc Natl Acad Sci U S A 99, 815-820

12. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES (1999): Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 22, 231-238

13. Chakravarti A (1999): Population genetics--making sense out of sequence.

Nat Genet 21, 56-60

14. Chavanne F, Broughton BC, Pietra D, Nardo T, Browitt A, Lehmann AR, Stefanini M (2000): Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.

Cancer Res 60, 1974-1982

15. Cheng L, Eicher SA, Guo Z, Hong WK, Spitz MR, Wei Q (1998): Reduced DNA repair capacity in head and neck cancer patients. Cancer Epidemiol Biomarkers Prev 7, 465-468

16. Cheng L, Spitz MR, Hong WK, Wei Q (2000): Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis.

Carcinogenesis 21, 1527-1530

17. Clark WH Jr., Evans HL, Everett MA, Farmer ER, Graham JH, Mihm MC Jr., Rosai J, Sagebiel RW, Wick MR (1991): Early melanoma. Histologic terms.

Am J Dermatopathol 13, 579-582

18. Cleaver JE, Charles WC, McDowell ML, Sadinski WJ, Mitchell DL (1995):

Overexpression of the XPA repair gene increases resistance to ultraviolet radiation in human cells by selective repair of DNA damage. Cancer Res 55, 6152-6160

19. Cooper PK, Nouspikel T, Clarkson SG, Leadon SA (1997): Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science 275, 990-993

20. de Boer BJ, Hoeijmakers JH (2000): Nucleotide excision repair and human syndromes. Carcinogenesis 21, 453-460

21. Demple B, Harrison L (1994): Repair of oxidative damage to DNA:

enzymology and biology. Annu Rev Biochem 63, 915-948

22. Denissenko MF, Pao A, Tang M, Pfeifer GP (1996): Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274, 430-432

23. Dybdahl M, Vogel U, Frentz G, Wallin H, Nexo BA (1999): Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma. Cancer Epidemiol Biomarkers Prev 8, 77-81

24. Elder DE, Goldman LI, Goldman SC, Greene MH, Clark WH, Jr. (1980):

Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer 46, 1787-1794

25. Emmert S, Kobayashi N, Khan SG, Kraemer KH (2000): The xeroderma pigmentosum group C gene leads to selective repair of cyclobutane pyrimidine dimers rather than 6-4 photoproducts. Proc Natl Acad Sci U S A 97, 2151-2156

26. Emmert S, Schneider TD, Khan SG, Kraemer KH (2001): The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms. Nucleic Acids Res 29, 1443-1452

27. Emmert S, Slor H, Busch DB, Batko S, Albert RB, Coleman D, Khan SG, bu-Libdeh B, DiGiovanna JJ, Cunningham BB, Lee MM, Crollick J, Inui H, Ueda T, Hedayati M, Grossman L, Shahlavi T, Cleaver JE, Kraemer KH (2002):

Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients. J Invest Dermatol 118, 972-982

28. Fritsch P, Zelger B, Stepp N: Tumoren der Haut; in: Dermatologie und Venerologie Lehrbuch und Atlas; hrsg. v. Fritsch P; Springer Verlag, Berlin 1998, 585-599

29. Garbe C, Schaumburg-Lever G: Klinik und Histologie des malignen Melanoms; in: Dermatologische Onkologie; hrsg. v. Garbe C, Dummer R, Kaufmann R, Tilgen W; Springer Verlag, Berlin 1997, 247-270

30. Garbe C, Blum A (2001): Epidemiology of cutaneous melanoma in Germany and worldwide. Skin Pharmacol Appl Skin Physiol 14, 280-290

31. Garbe C, Buttner P, Ellwanger U, Orfanos CE (1995): Management of primary malignant melanoma of the skin in German-speaking countries 1983-1993. A study of the Malignant Melanoma Central Register of the German Society of Dermatology. Hautarzt 46, 762-770

32. Gilchrest BA, Eller MS, Geller AC, Yaar M (1999): The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 340, 1341-1348 33. Goukassian D, Gad F, Yaar M, Eller MS, Nehal US, Gilchrest BA (2000):

Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J 14, 1325-1334

34. Gozukara EM, Khan SG, Metin A, Emmert S, Busch DB, Shahlavi T, Coleman DM, Miller M, Chinsomboon N, Stefanini M, Kraemer KH (2001): A stop codon in xeroderma pigmentosum group C families in Turkey and Italy: molecular genetic evidence for a common ancestor. J Invest Dermatol 117, 197-204 35. Greene MH, Clark WH, Jr., Tucker MA, Elder DE, Kraemer KH, Guerry D,

Witmer WK, Thompson J, Matozzo I, Fraser MC (1985a): Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome. N Engl J Med 312, 91-97

36. Greene MH, Clark WH, Jr., Tucker MA, Kraemer KH, Elder DE, Fraser MC (1985b): High risk of malignant melanoma in melanoma-prone families with dysplastic nevi. Ann Intern Med 102, 458-465

37. Haenssle HA, Vente C, Bertsch HP, Rupprecht R, Abuzahra F, Junghans V, Ellinghaus B, Emmert S, Hallermann C, Rosenberger A, Neumann C (2004):

Results of a surveillance programme for patients at high risk of malignant melanoma using digital and conventional dermoscopy. Eur J Cancer Prev 13, 133-138

38. Hemminki K, Xu G, Angelini S, Snellman E, Jansen CT, Lambert B, Hou SM (2001): XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ. Carcinogenesis 22, 1185-1188

39. Hey T, Lipps G, Sugasawa K, Iwai S, Hanaoka F, Krauss G (2002): The XPC-HR23B complex displays high affinity and specificity for damaged DNA in a true-equilibrium fluorescence assay. Biochemistry 41, 6583-6587

40. Higgins EM, Du Vivier AW (1992): Possible induction of malignant melanoma by sunbed use. Clin Exp Dermatol 17, 357-359

41. Hoeijmakers JH (2001): Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374

42. Jeon HS, Kim KM, Park SH, Lee SY, Choi JE, Lee GY, Kam S, Park RW, Kim IS, Kim CH, Jung TH, Park JY (2003): Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer. Carcinogenesis 24, 1677-1681 43. Johnson TM, Hamilton T, Lowe L (1998): Multiple primary melanomas. J Am

Acad Dermatol 39, 422-427

44. Khan SG, Levy HL, Legerski R, Quackenbush E, Reardon JT, Emmert S, Sancar A, Li L, Schneider TD, Cleaver JE, Kraemer KH (1998): Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia. J Invest Dermatol 111, 791-796

45. Khan SG, Metter EJ, Tarone RE, Bohr VA, Grossman L, Hedayati M, Bale SJ, Emmert S, Kraemer KH (2000): A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism. Carcinogenesis 21, 1821-1825 46. Khan SG, Muniz-Medina V, Shahlavi T, Baker CC, Inui H, Ueda T, Emmert S,

Schneider TD, Kraemer KH (2002): The human XPC DNA repair gene:

arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function. Nucleic Acids Res 30, 3624-3631

47. Klungland A, Hoss M, Gunz D, Constantinou A, Clarkson SG, Doetsch PW, Bolton PH, Wood RD, Lindahl T (1999): Base excision repair of oxidative DNA damage activated by XPG protein. Mol Cell 3, 33-42

48. Kraemer KH, Greene MH, Tarone R, Elder DE, Clark WH, Jr., Guerry D (1983): Dysplastic naevi and cutaneous melanoma risk. Lancet 1983,2, 1076-1077

49. Kraemer KH, Lee MM, Scotto J (1984): DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum.

Carcinogenesis 5, 511-514

50. Kraemer KH, Lee MM, Scotto J (1987): Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 123, 241-250

51. Kraemer KH, Lee MM, Andrews AD, Lambert WC (1994): The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol 130, 1018-1021

52. Kumar R, Hoglund L, Zhao C, Forsti A, Snellman E, Hemminki K (2003):

Single nucleotide polymorphisms in the XPG gene: determination of role in DNA repair and breast cancer risk. Int J Cancer 103, 671-675

53. Lindahl T, Wood RD (1999): Quality control by DNA repair. Science 286, 1897-1905

54. Malarstig A, Tenno T, Jossan S, Aberg M, Siegbahn A (2003): A quantitative real-time PCR method for tissue factor mRNA. Thromb Res 112, 175-183 55. Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T,

Takio K, Tanaka K, van der Spek PJ, Bootsma D (1994): Purification and cloning of a nucleotide excision repair complex involving the xeroderma

pigmentosum group C protein and a human homologue of yeast RAD23.

EMBO J 13, 1831-1843

56. Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (1999): The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature 399, 700-704 57. Matsui MS, DeLeo VA (1991): Longwave ultraviolet radiation and promotion of

skin cancer. Cancer Cells 3, 8-12

58. Mitchell DL, Nairn RS (1989): The biology of the (6-4) photoproduct.

Photochem Photobiol 49, 805-819

59. Mohrenweiser HW, Jones IM (1998): Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation? Mutat Res 400, 15-24

60. Moriwaki S, Ray S, Tarone RE, Kraemer KH, Grossman L (1996): The effect of donor age on the processing of UV-damaged DNA by cultured human cells:

reduced DNA repair capacity and increased DNA mutability. Mutat Res 364, 117-123

61. Mu D, Sancar A (1997): Model for XPC-independent transcription-coupled repair of pyrimidine dimers in humans. J Biol Chem 272, 7570-7573

62. Mu D, Hsu DS, Sancar A (1996): Reaction mechanism of human DNA repair excision nuclease. J Biol Chem 271, 8285-8294

63. Nashan D, Kocer B, Schiller M, Luger T, Grabbe S (2003): Significant risk of a second melanoma in patients with a history of melanoma but no further predisposing factors. Dermatology 206, 76-77

64. Nelemans PJ, Groenendal H, Kiemeney LA, Rampen FH, Ruiter DJ, Verbeek AL (1993): Effect of intermittent exposure to sunlight on melanoma risk among indoor workers and sun-sensitive individuals. Environ Health Perspect 101, 252-255

65. Nelson HH, Kelsey KT, Mott LA, Karagas MR (2002): The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. Cancer Res 62, 152-155

66. Newton Bishop JA, Harland M, Bishop DT (1998): The genetics of melanoma:

the UK experience. Clin Exp Dermatol 23, 158-161

67. Nouspikel T, Clarkson SG (1994): Mutations that disable the DNA repair gene XPG in a xeroderma pigmentosum group G patient. Hum Mol Genet 3, 963-967

68. Nouspikel T, Lalle P, Leadon SA, Cooper PK, Clarkson SG (1997): A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function. Proc Natl Acad Sci U S A 94, 3116-3121

69. Nystrom K, Biller M, Grahn A, Lindh M, Larson G, Olofsson S (2004): Real time PCR for monitoring regulation of host gene expression in herpes simplex virus type 1-infected human diploid cells. J Virol Methods 118, 83-94

70. Oesch F, Aulmann W, Platt KL, Doerjer G (1987): Individual differences in DNA repair capacities in man. Arch Toxicol Suppl 10, 172-179

71. Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J (1997): Cancer incidence in five continents. (IARC Sci. Publ.,Volume VII); IARC Sci. Publ., Lyon 1997

72. Qiao Y, Spitz MR, Shen H, Guo Z, Shete S, Hedayati M, Grossman L, Mohrenweiser H, Wei Q (2002): Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. Carcinogenesis 23, 295-299

73. Reardon JT, Mu D, Sancar A (1996): Overproduction, purification, and characterization of the XPC subunit of the human DNA repair excision nuclease. J Biol Chem 271, 19451-19456

74. Reardon JT, Bessho T, Kung HC, Bolton PH, Sancar A (1997): In vitro repair of oxidative DNA damage by human nucleotide excision repair system:

possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc Natl Acad Sci U S A 94, 9463-9468

75. Runger TM (1999): Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer. A short review. Photodermatol Photoimmunol Photomed 15, 212-216

76. Runger TM, Epe B, Moller K (1995): Repair of ultraviolet B and singlet oxygen-induced DNA damage in xeroderma pigmentosum cells. J Invest Dermatol 104, 68-73

77. Sanyal S, Festa F, Sakano S, Zhang Z, Steineck G, Norming U, Wijkstrom H, Larsson P, Kumar R, Hemminki K (2004): Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis 25, 729-734

78. Schneider TD (1997): Sequence walkers: a graphical method to display how binding proteins interact with DNA or RNA sequences. Nucleic Acids Res 25, 4408-4415

79. Setlow RB, Grist E, Thompson K, Woodhead AD (1993): Wavelengths effective in induction of malignant melanoma. Proc Natl Acad Sci U S A 90, 6666-6670

80. Shen H, Sturgis EM, Khan SG, Qiao Y, Shahlavi T, Eicher SA, Xu Y, Wang X, Strom SS, Spitz MR, Kraemer KH, Wei Q (2001): An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study. Cancer Res 61, 3321-3325

81. Shen MR, Jones IM, Mohrenweiser H (1998): Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res 58, 604-608

82. Stang K, Stang A, Stegmaier C, Ziegler H, Eisinger B, Stabenow R, Jockel KH (2000): Descriptive epidemiology of cutaneous malignant melanoma. Analyses of German Cancer Registry data. Stud Health Technol Inform 77,139-142

83. Sturgis EM, Zheng R, Li L, Castillo EJ, Eicher SA, Chen M, Strom SS, Spitz MR, Wei Q (2000): XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis. Carcinogenesis 21, 2219-2223

84. Sugasawa K, Ng JM, Masutani C, Maekawa T, Uchida A, van der Spek PJ, Eker AP, Rademakers S, Visser C, Aboussekhra A, Wood RD, Hanaoka F, Bootsma D, Hoeijmakers JH (1997): Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol Cell Biol 17, 6924-6931

85. Sugasawa K, Ng JM, Masutani C, Iwai S, van der Spek PJ, Eker AP, Hanaoka F, Bootsma D, Hoeijmakers JH (1998): Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.

Mol Cell 2, 223-232

86. Sugasawa K, Shimizu Y, Iwai S, Hanaoka F (2002): A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst) 1, 95-107

87. Swerdlow AJ, English JS, MacKie RM, O'Doherty CJ, Hunter JA, Clark J, Hole DJ (1988): Fluorescent lights, ultraviolet lamps, and risk of cutaneous melanoma. BMJ 297, 647-650

88. Swift M, Chase C (1979): Cancer in families with xeroderma pigmentosum. J Natl Cancer Inst 62, 1415-1421

89. Takahashi E, Shiomi N, Shiomi T (1992): Precise localization of the excision repair gene, ERCC5, to human chromosome 13q32.3-q33.1 by direct R-banding fluorescence in situ hybridization. Jpn J Cancer Res 83, 1117-1119 90. Tomescu D, Kavanagh G, Ha T, Campbell H, Melton DW (2001): Nucleotide

excision repair gene XPD polymorphisms and genetic predisposition to melanoma. Carcinogenesis 22, 403-408

91. Traupe H: Genetische Erkrankungen mit erhöhtem krebsrisiko und ihre Betreuung; in: Dermatologische Onkologie: hrsg. v. Garbe C, Dummer R, Kaufmann R, Tilgen W; Springer Verlag, Berlin 1997, 599-607

92. Tucker MA, Fraser MC, Goldstein AM, Elder DE, Guerry D, Organic SM (1993): Risk of melanoma and other cancers in melanoma-prone families. J Invest Dermatol 100, 350S-355S

93. van Steeg SH, Kraemer KH (1999): Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer. Mol Med Today 5, 86-94

94. Vodicka P, Kumar R, Stetina R, Sanyal S, Soucek P, Haufroid V, Dusinska M, Kuricova M, Zamecnikova M, Musak L, Buchancova J, Norppa H, Hirvonen A, Vodickova L, Naccarati A, Matousu Z, Hemminki K (2004): Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis 25, 757-763

95. Volker M, Mone MJ, Karmakar P, van HA, Schul W, Vermeulen W, Hoeijmakers JH, van DR, van Zeeland AA, Mullenders LH (2001): Sequential assembly of the nucleotide excision repair factors in vivo. Mol Cell 8, 213-224 96. Wakasugi M, Reardon JT, Sancar A (1997): The non-catalytic function of XPG

protein during dual incision in human nucleotide excision repair. J Biol Chem 272, 16030-16034

97. Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L (1993): DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.

Proc Natl Acad Sci U S A 90, 1614-1618

98. Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L (1995): DNA repair capacity for ultraviolet light-induced damage is reduced in peripheral lymphocytes from patients with basal cell carcinoma. J Invest Dermatol 104, 933-936

99. Wei Q, Cheng L, Hong WK, Spitz MR (1996): Reduced DNA repair capacity in lung cancer patients. Cancer Res 56, 4103-4107

100. Wei Q, Lee JE, Gershenwald JE, Ross MI, Mansfield PF, Strom SS, Wang LE, Guo Z, Qiao Y, Amos CI, Spitz MR, Duvic M (2003): Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J Natl

101. Wood RD (1999): DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie 81, 39-44

102. Wood RD, Mitchell M, Sgouros J, Lindahl T (2001): Human DNA repair genes.

Science 291, 1284-1289

103. Wu X, Zhao H, Wei Q, Amos CI, Zhang K, Guo Z, Qiao Y, Hong WK, Spitz MR (2003): XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity. Carcinogenesis 24, 505-509

104. Yaar M, Gilchrest BA (2001): Ageing and photoageing of keratinocytes and melanocytes. Clin Exp Dermatol 26, 583-591

105. Youl P, Aitken J, Hayward N, Hogg D, Liu L, Lassam N, Martin N, Green A (2002): Melanoma in adolescents: a case-control study of risk factors in Queensland, Australia. Int J Cancer 98, 92-98

106. Yuspa SH, Dlugosz AA, Cheng CK, Denning MF, Tennenbaum T, Glick AB, Weinberg WC (1994): Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J Invest Dermatol 103, 90S-95S

Danksagung

Für die Möglichkeit, die Arbeit in der Abteilung Dermatologie und Venerologie der Georg-August-Universität Göttingen absolvieren zu können, bedanke ich mich herzlich bei Frau Prof. Dr. Ch. Neumann.

Herrn PD. Dr. med. S. Emmert danke ich für die Bereitstellung des Themas, die hervorragende wissenschaftliche Betreuung dieser Arbeit, die Besprechung der Ergebnisse und die freundschaftliche Zusammenarbeit. Die Arbeitsgruppe wurde von der Deutschen Forschungsgemeinschaft (DFG) gefördert.

Frau Laspe und Frau Zachmann danke ich sehr für die Unterstützung bei der Durchführung und Auswertung der Experimente.

Frau Dr. rer. biol. hum. I. König und Herrn Prof. Dr. rer. nat. A. Ziegler vom Institut für Medizinische Biometrie und Statistik des Universitätsklinikums Schleswig-Holstein, Campus Lübeck, danke ich für die Unterstützung bei der statistischen Auswertung der Daten.

Herrn Dr. med. V. Blaschke möchte ich für die Unterstützung in der Etablierung der LightCycler Experimente danken.

Mein Dank gilt ebenso allen hier namentlich nicht-genannten Mitarbeitern des Forschungslabors der Hautklinik für die gute Zusammenarbeit.

Lebenslauf

Am 10. Februar 1980 wurde ich, Sandra Blankenburg, als einziges Kind von Jutta Blankenburg, geb. Schwabrow, und Bernd Blankenburg, in Reinbek geboren.

Von 1986-1990 besuchte ich die Grund- und Hauptschule Nordost in Schwarzenbek.

Im August 1990 wechselte ich zum Gymnasium Schwarzenbek. Das Schuljahr 1996/1997 verbrachte ich an der GlenOak Highschool in Canton, OH, USA. 1999 verließ ich das Gymnasium Schwarzenbek mit der Allgemeinen Hochschulreife.

Im Oktober 1999 begann ich das Medizinstudium an der Georg-August-Universität Göttingen. Im September 2001 legte ich erfolgreich die Ärztliche Vorprüfung ab. Im August 2002 bestand ich das 1. Staatsexamen. Im Herbst 2004 strebe ich das 2.

Staatsexamen an und werde ein Tertial meines praktischen Jahres am Kantonsspital Chur in der Schweiz ableisten.

Einen Monat meiner Famulaturen absovierte ich in der Abteilung Innere Medizin des Johanniter Krankenhauses in Geesthacht. Für eine 15-tägige Famulatur besuchte ich die Abteilung Anästhesie-, Rettungs- und Intensivmedizin des Universitätsklinikums Göttingen. Einen weiteren Monat verbrachte ich in den Abteilungen Gynäkologie und Geburtshilfe sowie Kinderchirurgie des Tokai Universitätshospitals in Isehara, Japan.

Eine 3-wöchige Famulatur leistete ich zudem in der Abteilung Hals-Nasen-Ohrenheilkunde im Krankenhaus Winsen an der Luhe ab. Meine Praxisfamulaturen habe ich in der radiologischen Gemeinschaftspraxis Kretsch, Klengl, Samse und Leinweber in Göttingen und der Abteilung Dermatologie und Venerologie des Universitätsklinikums Göttingen durchgeführt.