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1. Bailes BK

Diabetes mellitus and its chronic complications AORN J 76:266-276, 2002

2. Baskin DG, Hahn TM, Schwartz MW Leptin sensititve neurons in the hypothalamus Horm Metab Res 31:345-50, 1999

3. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

Proc Natl Acad Sci USA 93:8374-8378, 1996

4. Beck F, Plummer S, Senior PV, Byrne S, Green S, Brammar WJ The ontogeny of peroxisome proliferator-activated receptor gene expression in the mouse and rat

Proc R Soc Lond[Biol]247:83-87, 1992

5. Bouchard C

The causes of obesity: advances in molecular biology but stagnation on the genetic front

Diabetologia 39:1532-1533, 1996

6. Bouchard C

The genetics of human obesity: recent progress Bull Mem Acad R Med Belg 156:455-62, 2001

7. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W

Differential expression of peroxisome proliferator-activated receptors:

tissue distribution of PPARα,βandγin the adult rat Endocrinology 137:354-366, 1996

8. Brun RP, Kim JB, Hu E and Spiegelman BM

Peroxisome proliferator-activated receptor gamma and the control of adipogenesis

Curr Opin Lipidol 8:212-218, 1997

9. Campfield LA, Smith FJ, Guisez Y, Devoz R, Burn P

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

Science 269:546-549, 1995

10. Chagnon YC, Pérusse L and Bouchard C

Familial aggregation of obesity, candidate genes and quantitative trait loci

Curr Opin Lipidol 8:205-211, 1997

11. Chen H, Charlat O, Tartaglia LA, Woolf EA, Wenig X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE et al.

Evidence that the diabetes gene encodes the leptin receptor:

identification of a mutation in the leptin receptor gene in db/db mice Cell 84:491-495, 1996

12. Clement K, Boutin P, Froguel P Genetics of obesity

Am J Pharmacogenomics 2:177-187, 2002

14. Coleman DL, Eicher EM

Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse

J Hered 88:424-427, 1990

15. Cook KS, Min HY, Johnson D, Chaplinsky RJ, Flier FS, Hunt CR, Spiegelman BM

Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve

Science 237:402-405, 1987

16. Cool DR, Normant E, Shen F, Chen H, Pannel L, Zhang Y, Loh YP Carboxypeptidase E is a regulated secretory pathway sorting receptor:

genetic obliteration leads to endocrine disorders in Cpe/fat mice Cell 88:73-83, 1997

17. Deedwania PC

Clinical significance of cardiovascular dysmetabolic syndrome Curr Control Trials Cardiovasc Med 3:2, 2002

18. Dulloo AG, Jaquet J

An adipose-specific control of thermogenesis in body weight regulation Int J Obes Relat Metab Disord 25 Suppl 5:22-29, 2001

19. Elmquist JK

Hypothalamic pathways underlying the endocrine, autonomic and behavioural effects of leptin

Physiol Behav 74:703-708, 2001

20. Ek J, Urhammer SA, Sorensen TI, Andersen T, Auwerx J, Pedersen O

Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men

Diabetologia 42:892-895, 1999

21. Evans RM

The steroid and thyroid hormone receptor superfamily Science 240:889-895, 1988

22. Erickson JC, Clegg KE, Palmiter RD

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

Nature 381:415, 1996

23. Froguel P, Guy-Grand B, Clement K

Genetics of obesity: towards the understanding of a complex syndrome Presse Med 29:564-571, 2000

24. Gerald C, Walker MW, Criscione L, Gustafson EL,

Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL et al.

A receptor subtype involved in neuropeptide-Y-induced food intake Nature 382:168-171, 1996

25. Green S and P Chambon

Nuclear receptors enhance our understanding of transcriptional regulation

Trends Genet 4:309-314, 1988

26. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM

Weight-reducing effects of the plasma protein encoded by the obese gene

Science 269:543-546, 1995

27. Hamer OE, Forstner D, Ottinger I, Ristow M, Bollheimer LC, Scholmerich J, Palitzsch KD

The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity

Exp Clin Endocrinol Diabetes 110:230-234, 2002

28. Hensrud DD

Dietary treatment and long-term weight loss and maintenance in type 2 diabetes

Obes Res 9 Suppl 4:348-353, 2001

29. Hotamisligil GS, Shargill NS, Spiegelman BM Adipose expression of tumor necrosis factor alpha:

direct role in obesity-linked insulin resistance Science 259:87-91, 1993

30. Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS Kasper DL

Harrisons Innere MEDIZIN

Blackwell Wissenschaftsverlag, 13. Auflage 1995

31. Isseman I and S Green

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Nature 347:645-650, 1990

32. Isseman I, Prince R, Tugwood JD, Green S

A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation

Biochem Soc Trans 20:842-827, 1992

33. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS

Interacting appetite-regulating pathways in the hypothalamic regulation of body weight

Endocr Rev 20:68-100, 1999

34. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors Nature 358:771-774, 1992

35. Kyulo N, Knutsen S, Singh P

Effect of history of overweight/obesity on health outcomes observed in those in the recommended range of body weight (19-25 kg/m(2))

Ann Epidemiol 12:500, 2002

36. Kwon HY, Bultman SJ, Loffler C, Chen WJ, Furdon PJ, Powell JG, Usala AL, Wilkison W, Hansmann I, Woychik RP Molecular strcture and chromosomal mapping of the human homolog of the agouti gene

Proc Natl Acad Sci U S A 91:9760-9764, 1994

37. Larsen PJ, Vrang N, Tang-Christensen M; Jensen PB, Hay-Schmidt A, Romer J, Bjerre-Knudsen L, Kristensen P Ups and downs for neuropeptides in body weight homeostasis:

pharmacological potential of cocaine amphetamine regulated transcript

38. Lei HH, Chen MH, Yang WS, Chiu MC, Chen MC, Tai TY, Chuang LM

Peroxisome proliferator-activated receptor gamma2 Pro12Ala gene variant is strongly associated with larger body mass in the Taiwanese Metabolism 49:1267-1270, 2000

39. Leonetti F, Lacobellis G, Zappaterreno A, Di Mario U

Clinical, physiopathological and dietic aspects of metabolic syndrome Dig liver Dis 34 Suppl 2:134-139, 2002

40. Lock EA, Mitchell AM, Elcombe CR

Biochemical mechanisms of induction of hepatic peroxisome proliferation

Annu Rev Pharmacol Toxicol 29:145-163, 1989

41. Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik R, Wilkison WO

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Nature 371:799-802, 1994

42. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O´Rahilly S Congenital leptin deficiency is associated with severe early-onset obesity in humans

Nature 387:903-908, 1997

43. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD Localisation of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

Mol Endocrinol 8:1298-1308, 1994

44. Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM

Genetic analysis of adipogenesis through PPARgamma isoforms J Biol Chem 277:41925-41930, 2002

45. Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, Steiner DF, Carroll RJ, Paigen BJ, Leiter EH

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity Nat Genet 10:135-142, 1995

46. Naggert J, Harris T and North M The genetics of obesity

Curr Opin of Genetics & Development 7:398-404, 1997

47. Norman RA, Leibel RL, Chung WK, Power-Kehoe L, Chua SC Jr., Knowler WL, Thompson DB, Bogardus C, Ravussin E

Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians Diabetes 45:1229-1232, 1996

48. Osmundsen H, Bremer J, Pedersen JI Metabolic aspects of peroxisomalβ-oxidation Biochim Biophys Acta 1085:141-158, 1991

49. Pathak R, Afaq A, Blonde L

Thiazolidinediones in the treatment of managed care patients with type 2 diabetes

Am J Manag Care 8:483-484, 2002

50. Peiris AN, Sothmann MS, Hoffmann RG, Hennes MI, Wilson CR, Gustafson AB, Kissebah AH

Adiposity, fat distribution and cardiovascular risk Ann Intern Med 110:867-872, 1989

51. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F

Effects of the obese gene product on body weight regulation in ob/ob mice

Science 269:540-543, 1995

52. Pi-Sunyer FX

The medical risks of obesity Obes Surg 12 Suppl 1:6-11, 2002

53. Ristow M, Müller-Wieland D, Pfeiffer A, Krone W and Kahn C R Obesity associated with a mutation in a genetic regulator of adipocyte differentiation

N Engl J Med 339:953-9, 1998

54. Rodriguez JC, Gil-Gomez G, Hegardt FG, Haro D

Peroxisome proliferator activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthetase gene by fatty acids

J Biol Chem 269:18767-18772, 1994

55. Rosenkranz K, Hinney A, Ziegler A, von Prittwitz S, Barth N, Roth H, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt M, Schafer H, Remschmidt H, Hebebrand J

Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extemes

Int J Obes Relat Metab Disord 22:157-63, 1998

56. Sahu A

Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin in neuropeptide Y neurones

J Neuroendocrinol 14:796-804, 2002

57. Saladin R, Fajas L, Dana S, Halvorsen YD, Auwerx J and Briggs M Differential regulation of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis

Cell Growth Differ 10(1):43-8, 1999

58. Schaffler A, Barth N, Schmitz G, Zietz B, Palitzsch KD, Scholmerich J

Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma

regarding metabolic parameters in a Caucasian cohort Endocrine 24:369-373, 2001

59. Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, Auwerx J

Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter

J Biol Chem 270:19269-19276, 1995

60. Schoonjans K, Staels B and Auwerx J

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression J. Lipid Res. 37:907-925, 1996

61. Schoonjans K, Staels B, Deeb S, Auwerx J

PPARαand PPARγactivators direct a tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene

Submitted, 1996

62. Schwandt P, Richter WO

Handbuch der Fettstoffwechselstörungen Schattauer, 2. Auflage 2000

63. Seidell JC

Obesity, insulin resistance and diabetes-a worldwide epidemic Br J Nutr 83 Suppl 1:5-8, 2000

64. Smith CK, Romsos DR

Cold acclimation of obese (ob/ob) mice: effects on skeletal muscle and bone

Metabolism 33:858-863, 1984

65. Stunkard AJ, Harris JR, Pedersen, NL., Mc Clearn GE The body-mass index of twins who have been reared apart N Engl J Med 322:1483-1487, 1990

66. Tennyson GE

Understanding type 2 diabetes mellitus and associated cardiovascular disease: linked by insulin resistance

Am J Manag Care 8:450-459, 2002

67. Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPARγand RXRα Nucleic Acids Res 22:5628-5634, 1994

68. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM mPPARγ2: tissue-specific regulator of an adipocyte enhancer Genes Dev 8: 1224-1234, 1994

69. Wilding JP

Neuropeptides and appetite control Diabet Med 19:619-627, 2002

70. William G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH The hypothalamus and the control of energy homeostasis: different circuits, different purposes

Physiol Behav 74:683-701, 2001

71. Yen TY, Gill AM, Frigeri LG, Barsh GS, Wolff GL

Obesity, diabetes and neoplasia in yellow Avy/-mice: ectopic expression of the agouti-gene

FASEB J 8:479-488, 1994

72. York C, Bouchard C

How obesity develops:insights from the new biology Endocrine 13:143-154, 2000

73. York DA

Peripheral and central mechanisms regulating food intake and macronutrient selection

Obes Surg 9:471-479, 1999

74. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM

Positional cloning of the mouse obese gene and ist human homologue

75. Zhu Y, Qi C, Korenberg JR, Chen X-N, Noya D, Rao MS, Reddy JK

Structural organisation of the mouse peroxisome proliferator-activated Receptorγ(mPPARγ) gene: alternative promotor use and different splicing yield two mPPARγisoforms

Proc Natl Acad Sci U S A 92:7921-7925, 1995