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Abdel Aziz, M. T., H. H. Fouad, G. A. Mohsen, M. Mansour and S. Abdel Ghaffar (2001). "TNF-alpha and homocysteine levels in type 1 diabetes mellitus." East Mediterr Health J 7(4-5): 679-688.

Ablamunits, V., O. Henegariu, J. B. Hansen, L. Opare-Addo, P. Preston-Hurlburt, P. Santamaria, T. Mandrup-Poulsen and K. C. Herold (2012). "Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation." Diabetes 61(1): 145-154.

Aguilar, A. and J. D. Saba (2012). "Truth and consequences of sphingosine-1-phosphate lyase." Adv Biol Regul 52(1): 17-30.

Al-Maskari, M. Y., M. I. Waly, A. Ali, Y. S. Al-Shuaibi and A. Ouhtit (2012).

"Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes." Nutrition 28(7-8): e23-26.

Alder, N. N., Y. Shen, J. L. Brodsky, L. M. Hendershot and A. E. Johnson (2005).

"The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum." J Cell Biol 168(3): 389-399.

Allagnat, F., D. Cunha, F. Moore, J. M. Vanderwinden, D. L. Eizirik and A. K.

Cardozo (2011). "Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis." Cell Death Differ 18(2): 328-337.

Allagnat, F., M. Fukaya, T. C. Nogueira, D. Delaroche, N. Welsh, L. Marselli, P.

Marchetti, J. A. Haefliger, D. L. Eizirik and A. K. Cardozo (2012). "C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells." Cell Death Differ 19(11): 1836-1846.

Altobelli, E., R. Petrocelli, A. Verrotti, F. Chiarelli and C. Marziliano (2016).

"Genetic and environmental factors affect the onset of type 1 diabetes mellitus." Pediatr Diabetes 17(8): 559-566.

Alvarez, S. E., S. Milstien and S. Spiegel (2007). "Autocrine and paracrine roles of sphingosine-1-phosphate." Trends Endocrinol Metab 18(8): 300-307.

Andralojc, K. M., A. Mercalli, K. W. Nowak, L. Albarello, R. Calcagno, L. Luzi, E.

Bonifacio, C. Doglioni and L. Piemonti (2009). "Ghrelin-producing epsilon cells in the developing and adult human pancreas." Diabetologia 52(3): 486-493.

Aragon, F., M. Karaca, A. Novials, R. Maldonado, P. Maechler and B. Rubi (2015).

"Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells." Biochim Biophys Acta 1850(2): 343-351.

Atkinson, M. A. (2005). "ADA Outstanding Scientific Achievement Lecture 2004.

Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?" Diabetes 54(5): 1253-1263.

Atkinson, M. A., G. S. Eisenbarth and A. W. Michels (2014). "Type 1 diabetes."

Lancet 383(9911): 69-82.

Atkinson, M. A. and N. K. Maclaren (1993). "Islet cell autoantigens in insulin-dependent diabetes." J Clin Invest 92(4): 1608-1616.

Atkinson, M. A. and N. K. Maclaren (1994). "The pathogenesis of insulin-dependent diabetes mellitus." N Engl J Med 331(21): 1428-1436.

Atkinson, M. A. and S. B. Wilson (2002). "Fatal attraction: chemokines and type 1 diabetes." J Clin Invest 110(11): 1611-1613.

Bach, J. F. (1994). "Insulin-dependent diabetes mellitus as an autoimmune disease."

Endocr Rev 15(4): 516-542.

Baekkeskov, S., H. J. Aanstoot, S. Christgau, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen and P. De Camilli (1990). "Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase." Nature 347(6289): 151-156.

Baker, M. S., X. Chen, X. C. Cao and D. B. Kaufman (2001). "Expression of a dominant negative inhibitor of NFB protects MIN6 beta-cells from cytokine-induced apoptosis." J Surg Res 97(2): 117-122.

Baldwin, A. S., (1996). "The NFB and IB proteins: new discoveries and insights."

Annu Rev Immunol 14: 649-683.

Banting, F. G., C. H. Best, J. B. Collip, W. R. Campbell and A. A. Fletcher (1922).

"Pancreatic extracts in the treatment of diabetes mellitus." Can Med Assoc J 12(3): 141-146.

Baseman, J. B., D. Paolini, Jr. and H. Amos (1974). "Stimulation by insulin of RNA synthesis in chick fibroblasts." J Cell Biol 60(1): 54-64.

Behrens, G., R. Winzen, N. Rehage, A. Dorrie, M. Barsch, A. Hoffmann, J.

Hackermuller, C. Tiedje, V. Heissmeyer and H. Holtmann (2018). "A translational silencing function of MCPIP1/Regnase-1 specified by the target site context." Nucleic Acids Res 46(8): 4256-4270.

Beisang, D. and P. R. Bohjanen (2012). "Perspectives on the ARE as it turns 25 years old." Wiley Interdiscip Rev RNA 3(5): 719-731.

Berchtold, L. A., M. Prause, J. Storling and T. Mandrup-Poulsen (2016).

"Cytokines and pancreatic beta-cell apoptosis." Adv Clin Chem 75: 99-158.

Bergholdt, R., P. Heding, K. Nielsen, R. Nolsoe, T. Sparre, J. Storling, J. Nerup, F.

Pociot and T. Mandrup-Poulsen (2004). "Type 1 database mellitus: an inflammatory disease of the islet." Adv Exp Med Biol 552: 129-153.

Berridge, M. J. (2002). "The endoplasmic reticulum: a multifunctional signaling organelle." Cell Calcium 32(5-6): 235-249.

Berridge, M. J., M. D. Bootman and H. L. Roderick (2003). "Calcium signalling:

dynamics, homeostasis and remodelling." Nat Rev Mol Cell Biol 4(7): 517-529.

Bertolotti, A., Y. Zhang, L. M. Hendershot, H. P. Harding and D. Ron (2000).

"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response." Nat Cell Biol 2(6): 326-332.

Bertrand, M. J., S. Lippens, A. Staes, B. Gilbert, R. Roelandt, J. De Medts, K.

Gevaert, W. Declercq and P. Vandenabeele (2011). "cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)." PLoS One 6(9): e22356.

Bottazzo, G. F., A. Florin-Christensen and D. Doniach (1974). "Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies." Lancet 2(7892):

1279-1283.

References

Bradley, J. R. (2008). "TNF-mediated inflammatory disease." J Pathol 214(2): 149-160.

Brady, B. L. and S. A. Muljo (2013). "RNA decay tolerizes: MCPIP1 (Zc3h12a) keeps inflammation in check by cleaving 3' UTRs." Immunol Cell Biol 91(5): 331-332.

Brissova, M., M. J. Fowler, W. E. Nicholson, A. Chu, B. Hirshberg, D. M. Harlan and A. C. Powers (2005). "Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy." J Histochem Cytochem 53(9):

1087-1097.

Brodsky, J. L., E. D. Werner, M. E. Dubas, J. L. Goeckeler, K. B. Kruse and A. A.

McCracken (1999). "The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct." J Biol Chem 274(6): 3453-3460.

Brooks, S. A., J. E. Connolly and W. F. Rigby (2004). "The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway." J Immunol 172(12): 7263-7271.

Brorsson, C. A., S. Onengut, W. M. Chen, J. Wenzlau, L. Yu, P. Baker, A. J.

Williams, P. J. Bingley, J. C. Hutton, G. S. Eisenbarth, P. Concannon, S. S. Rich, F. Pociot and C. Type 1 Diabetes Genetics (2015). "Novel association between immune-mediated susceptibility loci and persistent autoantibody positivity in type 1 diabetes." Diabetes 64(8): 3017-3027.

Brown, G. K. (2000). "Glucose transporters: structure, function and consequences of deficiency." J Inherit Metab Dis 23(3): 237-246.

Brozzi, F. and D. L. Eizirik (2016). "ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes." Ups J Med Sci 121(2): 133-139.

Brozzi, F., T. R. Nardelli, M. Lopes, I. Millard, J. Barthson, M. Igoillo-Esteve, F.

A. Grieco, O. Villate, J. M. Oliveira, M. Casimir, M. Bugliani, F. Engin, G. S.

Hotamisligil, P. Marchetti and D. L. Eizirik (2015). "Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms."

Diabetologia 58(10): 2307-2316.

Bugara, B., P. Konieczny, A. Wolnicka-Glubisz, L. Eckhart, H. Fischer, L.

Skalniak, J. Borowczyk-Michalowska, J. Drukala and J. Jura (2017). "MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes." J Dermatol Sci 87(1): 10-18.

Cabrera, O., D. M. Berman, N. S. Kenyon, C. Ricordi, P. O. Berggren and A.

Caicedo (2006). "The unique cytoarchitecture of human pancreatic islets has implications for islet cell function." Proc Natl Acad Sci U S A 103(7): 2334-2339.

Campbell-Thompson, M., A. Fu, J. S. Kaddis, C. Wasserfall, D. A. Schatz, A.

Pugliese and M. A. Atkinson (2016). "Insulitis and beta-cell mass in the natural history of type 1 diabetes." Diabetes 65(3): 719-731.

Campbell-Thompson, M. L., J. S. Kaddis, C. Wasserfall, M. J. Haller, A. Pugliese, D. A. Schatz, J. J. Shuster and M. A. Atkinson (2016). "The influence of type 1 diabetes on pancreatic weight." Diabetologia 59(1): 217-221.

Campbell, J. E. and D. J. Drucker (2013). "Pharmacology, physiology, and mechanisms of incretin hormone action." Cell Metab 17(6): 819-837.

Campbell, K. J., N. R. Chapman and N. D. Perkins (2001). "UV stimulation induces nuclear factor kappaB (NFB) DNA-binding activity but not transcriptional activation."

Biochem Soc Trans 29(Pt 6): 688-691.

Cantrell Stanford, J., A. J. Morris, M. Sunkara, G. J. Popa, K. L. Larson and S.

Ozcan (2012). "Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells." J Biol Chem 287(16): 13457-13464.

Cardozo, A. K., H. Heimberg, Y. Heremans, R. Leeman, B. Kutlu, M. Kruhoffer, T. Orntoft and D. L. Eizirik (2001). "A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells." J Biol Chem 276(52): 48879-48886.

Cardozo, A. K., F. Ortis, J. Storling, Y. M. Feng, J. Rasschaert, M. Tonnesen, F.

Van Eylen, T. Mandrup-Poulsen, A. Herchuelz and D. L. Eizirik (2005). "Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells." Diabetes 54(2): 452-461.

Cavallo, M. G., P. Pozzilli, C. Bird, M. Wadhwa, A. Meager, N. Visalli, A. J.

Gearing, D. Andreani and R. Thorpe (1991). "Cytokines in sera from insulin-dependent diabetic patients at diagnosis." Clin Exp Immunol 86(2): 256-259.

Chalfant, C. E. and S. Spiegel (2005). "Sphingosine phosphate and ceramide 1-phosphate: expanding roles in cell signaling." J Cell Sci 118(Pt 20): 4605-4612.

Chan, J. Y., G. J. Cooney, T. J. Biden and D. R. Laybutt (2011). "Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells." Diabetologia 54(7):

1766-1776.

Chan, S. J., P. Keim and D. F. Steiner (1976). "Cell-free synthesis of rat preproinsulins: characterization and partial amino acid sequence determination." Proc Natl Acad Sci U S A 73(6): 1964-1968.

Chang, I., N. Cho, S. Kim, J. Y. Kim, E. Kim, J. E. Woo, J. H. Nam, S. J. Kim and M. S. Lee (2004). "Role of calcium in pancreatic islet cell death by IFN/TNF." J Immunol 172(11): 7008-7014.

Chang, K. T., R. F. Niescier and K. T. Min (2011). "Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons." Proc Natl Acad Sci U S A 108(37): 15456-15461.

Chen, C. Y. and A. B. Shyu (1995). "AU-rich elements: characterization and importance in mRNA degradation." Trends Biochem Sci 20(11): 465-470.

Chen, Z. J. (2012). "Ubiquitination in signaling to and activation of IKK." Immunol Rev 246(1): 95-106.

Cheng, H., T. Addona, H. Keshishian, E. Dahlstrand, C. Lu, M. Dorsch, Z. Li, A.

Wang, T. D. Ocain, P. Li, T. F. Parsons, B. Jaffee and Y. Xu (2007). "Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop." Biochem Biophys Res Commun 352(3): 609-616.

Chiu, Y. H., M. Zhao and Z. J. Chen (2009). "Ubiquitin in NFB signaling." Chem Rev 109(4): 1549-1560.

Clapham, D. E. (2007). "Calcium signaling." Cell 131(6): 1047-1058.

References

Cnop, M., N. Welsh, J. C. Jonas, A. Jörns, S. Lenzen and D. L. Eizirik (2005).

"Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities." Diabetes 54 Suppl 2: S97-107.

Collombat, P., X. Xu, H. Heimberg and A. Mansouri (2010). "Pancreatic beta-cells:

from generation to regeneration." Semin Cell Dev Biol 21(8): 838-844.

Cook, D. L. and C. N. Hales (1984). "Intracellular ATP directly blocks K+ channels in pancreatic beta-cells." Nature 311(5983): 271-273.

Darville, M. I. and D. L. Eizirik (1998). "Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells." Diabetologia 41(9): 1101-1108.

Darville, M. I. and D. L. Eizirik (2001). "Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NFB and C/EBP." Diabetes 50(8): 1741-1748.

Darville, M. I., Y. S. Ho and D. L. Eizirik (2000). "NFB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells."

Endocrinology 141(1): 153-162.

Dayal, S., A. M. Devlin, R. B. McCaw, M. L. Liu, E. Arning, T. Bottiglieri, B.

Shane, F. M. Faraci and S. R. Lentz (2005). "Cerebral vascular dysfunction in methionine synthase-deficient mice." Circulation 112(5): 737-744.

De Vos, A., H. Heimberg, E. Quartier, P. Huypens, L. Bouwens, D. Pipeleers and F. Schuit (1995). "Human and rat beta-cells differ in glucose transporter but not in glucokinase gene expression." J Clin Invest 96(5): 2489-2495.

Degagne, E. and J. D. Saba (2014). "S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer."

Clin Exp Gastroenterol 7: 205-214.

Deng, L., C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C.

Pickart and Z. J. Chen (2000). "Activation of the IB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain." Cell 103(2): 351-361.

Dever, T. E. (2002). "Gene-specific regulation by general translation factors." Cell 108(4): 545-556.

Dimitriadis, G., P. Mitrou, V. Lambadiari, E. Maratou and S. A. Raptis (2011).

"Insulin effects in muscle and adipose tissue." Diabetes Res Clin Pract 93 Suppl 1: S52-59.

Dinarello, C. A. (1997). "Interleukin-1." Cytokine Growth Factor Rev 8(4): 253-265.

Dupraz, P., S. Cottet, F. Hamburger, W. Dolci, E. Felley-Bosco and B. Thorens (2000). "Dominant negative MyD88 proteins inhibit interleukin-1 /interferon -mediated induction of nuclear factor  B-dependent nitrite production and apoptosis in beta cells." J Biol Chem 275(48): 37672-37678.

Ea, C. K., L. Deng, Z. P. Xia, G. Pineda and Z. J. Chen (2006). "Activation of IKK by TNF  requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO." Mol Cell 22(2): 245-257.

Eizirik, D. L., A. K. Cardozo and M. Cnop (2008). "The role for endoplasmic reticulum stress in diabetes mellitus." Endocr Rev 29(1): 42-61.

Eizirik, D. L. and M. Cnop (2010). "ER stress in pancreatic beta cells: the thin red line between adaptation and failure." Sci Signal 3(110): pe7.

Eizirik, D. L., M. L. Colli and F. Ortis (2009). "The role of inflammation in insulitis and beta-cell loss in type 1 diabetes." Nat Rev Endocrinol 5(4): 219-226.

Eizirik, D. L., M. Flodstrom, A. E. Karlsen and N. Welsh (1996). "The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells."

Diabetologia 39(8): 875-890.

Eizirik, D. L. and T. Mandrup-Poulsen (2001). "A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis." Diabetologia 44(12): 2115-2133.

Eizirik, D. L., F. Moore, D. Flamez and F. Ortis (2008). "Use of a systems biology approach to understand pancreatic beta-cell death in type 1 diabetes." Biochem Soc Trans 36(Pt 3): 321-327.

Eizirik, D. L. and A. Op de Beeck (2018). "Coxsackievirus and type 1 diabetes mellitus: The Wolf's Footprints." Trends Endocrinol Metab 29(3): 137-139.

Eizirik, D. L., M. Sammeth, T. Bouckenooghe, G. Bottu, G. Sisino, M. Igoillo-Esteve, F. Ortis, I. Santin, M. L. Colli, J. Barthson, L. Bouwens, L. Hughes, L.

Gregory, G. Lunter, L. Marselli, P. Marchetti, M. I. McCarthy and M. Cnop (2012). "The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines." PLoS Genet 8(3):

e1002552.

Eldor, R., A. Yeffet, K. Baum, V. Doviner, D. Amar, Y. Ben-Neriah, G.

Christofori, A. Peled, J. C. Carel, C. Boitard, T. Klein, P. Serup, D. L. Eizirik and D. Melloul (2006). "Conditional and specific NFB blockade protects pancreatic beta cells from diabetogenic agents." Proc Natl Acad Sci U S A 103(13): 5072-5077.

Elsner, M., W. Gehrmann and S. Lenzen (2011). "Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells." Diabetes 60(1): 200-208.

Elsner, M., E. Gurgul-Convey and S. Lenzen (2006). "Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells." Free Radic Biol Med 41(5): 825-834.

Elsner, M., E. Gurgul-Convey and S. Lenzen (2008). "Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan." Antioxid Redox Signal 10(4): 691-699.

Elsner, M., M. Tiedge, B. Guldbakke, R. Munday and S. Lenzen (2002).

"Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan." Diabetologia 45(11): 1542-1549.

Elsner, M., M. Tiedge and S. Lenzen (2003). "Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan."

Diabetologia 46(12): 1713-1714.

Faraci, F. M. and S. R. Lentz (2004). "Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction." Stroke 35(2): 345-347.

Fawcett, T. W., J. L. Martindale, K. Z. Guyton, T. Hai and N. J. Holbrook (1999).

"Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein

References

(C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response." Biochem J 339 ( Pt 1): 135-141.

International Diabetes Federation (2018). "Ref Type: Online Source:

https://www.idf.org/"

Filippi, C. M. and M. G. von Herrath (2008). "Viral trigger for type 1 diabetes: pros and cons." Diabetes 57(11): 2863-2871.

Flodström, M., N. Welsh and D. L. Eizirik (1996). "Cytokines activate the nuclear factor  B (NFB) and induce nitric oxide production in human pancreatic islets." FEBS Lett 385(1-2): 4-6.

Fox, T. E., M. C. Bewley, K. A. Unrath, M. M. Pedersen, R. E. Anderson, D. Y.

Jung, L. S. Jefferson, J. K. Kim, S. K. Bronson, J. M. Flanagan and M. Kester (2011). "Circulating sphingolipid biomarkers in models of type 1 diabetes." J Lipid Res 52(3): 509-517.

Fu, M. and P. J. Blackshear (2017). "RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins." Nat Rev Immunol 17(2): 130-143.

Gehrmann, W., W. Wurdemann, T. Plotz, A. Jorns, S. Lenzen and M. Elsner (2015). "Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells." Cell Physiol Biochem 36(3): 852-865.

Gepts, W. (1965). "Pathologic anatomy of the pancreas in juvenile diabetes mellitus."

Diabetes 14(10): 619-633.

Gilmartin, A. B., S. H. Ural and J. T. Repke (2008). "Gestational diabetes mellitus."

Rev Obstet Gynecol 1(3): 129-134.

Gilmore, T. D. (1999). "The Rel/NFB signal transduction pathway: introduction."

Oncogene 18(49): 6842-6844.

Gloire, G., S. Legrand-Poels and J. Piette (2006). "NFB activation by reactive oxygen species: fifteen years later." Biochem Pharmacol 72(11): 1493-1505.

Goetzl, E. J., W. Wang, C. McGiffert, J. J. Liao and M. C. Huang (2007).

"Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity." Acta Paediatr 96(455): 49-52.

Greenfeder, S. A., T. Varnell, G. Powers, K. Lombard-Gillooly, D. Shuster, K. W.

McIntyre, D. E. Ryan, W. Levin, V. Madison and G. Ju (1995). "Insertion of a structural domain of interleukin (IL)-1  confers agonist activity to the IL-1 receptor antagonist. Implications for IL-1 bioactivity." J Biol Chem 270(38): 22460-22466.

Greenlund, A. C., M. A. Farrar, B. L. Viviano and R. D. Schreiber (1994). "Ligand-induced IFN  receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)." EMBO J 13(7): 1591-1600.

Gromada, J., I. Franklin and C. B. Wollheim (2007). "Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains." Endocr Rev 28(1): 84-116.

Gromada, J., M. Hoy, K. Buschard, A. Salehi and P. Rorsman (2001).

"Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules." J Physiol 535(Pt 2): 519-532.

Guay, C. and R. Regazzi (2013). "Circulating microRNAs as novel biomarkers for diabetes mellitus." Nat Rev Endocrinol 9(9): 513-521.

Gurgul-Convey, E., I. Mehmeti, S. Lortz and S. Lenzen (2011). "Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria." J Mol Med (Berl) 89(8): 785-798.

Gurgul-Convey, E., K. Hanzelka and S. Lenzen (2012). "Mechanism of prostacyclin-induced potentiation of glucose-prostacyclin-induced insulin secretion." Endocrinology 153(6):2612-22

Gurgul-Convey, E., I. Mehmeti, T. Plötz, A. Jörns and S. Lenzen (2016).

"Sensitivity profile of the human EndoC-H1 beta cell line to proinflammatory cytokines." Diabetologia 59(10): 2125-2133.

Gurgul, E., S. Lortz, M. Tiedge, A. Jörns and S. Lenzen (2004). "Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines." Diabetes 53(9): 2271-2280.

Gurzov, E. N. and D. L. Eizirik (2011). "Bcl-2 proteins in diabetes: mitochondrial pathways of beta-cell death and dysfunction." Trends Cell Biol 21(7): 424-431.

Hahn, C., K. Tyka, J. D. Saba, S. Lenzen and E. Gurgul-Convey (2017).

"Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity." J Biol Chem 292(49): 20292-20304.

Hamilton, M. T., D. G. Hamilton and T. W. Zderic (2007). "Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease." Diabetes 56(11): 2655-2667.

Hänninen, A. J., S. Salmi, S. Toikkanen, S. Nikolakaros, G. Simell, O. (1992).

"Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus." J Clin Invest. 90(5): 1901–1910.

Hanzelka, K., L. Skalniak, J. Jura, S. Lenzen and E. Gurgul-Convey (2012).

"Effects of the novel mitochondrial protein mimitin in insulin-secreting cells." Biochem J 445(3): 349-359.

Harding, H. P., Y. Zhang, A. Bertolotti, H. Zeng and D. Ron (2000). "Perk is essential for translational regulation and cell survival during the unfolded protein response." Mol Cell 5(5): 897-904.

Hasnain, S. Z., R. Lourie, I. Das, A. C. Chen and M. A. McGuckin (2012). "The interplay between endoplasmic reticulum stress and inflammation." Immunol Cell Biol 90(3): 260-270.

Hauge-Evans, A. C., A. J. King, D. Carmignac, C. C. Richardson, I. C. Robinson, M. J. Low, M. R. Christie, S. J. Persaud and P. M. Jones (2009). "Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function." Diabetes 58(2): 403-411.

Heimberg, H., Y. Heremans, C. Jobin, R. Leemans, A. K. Cardozo, M. Darville and D. L. Eizirik (2001). "Inhibition of cytokine-induced NFB activation by adenovirus-mediated expression of a NFB super-repressor prevents beta-cell apoptosis." Diabetes 50(10): 2219-2224.

Heng, L. Z., O. Comyn, T. Peto, C. Tadros, E. Ng, S. Sivaprasad and P. G. Hykin (2013). "Diabetic retinopathy: pathogenesis, clinical grading, management and future developments." Diabet Med 30(6): 640-650.

Hetz, C. (2012). "The unfolded protein response: controlling cell fate decisions under ER stress and beyond." Nat Rev Mol Cell Biol 13(2): 89-102.

References

Hofmeister-Brix, A., S. Lenzen and S. Baltrusch (2013). "The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta-cells." Biochem J 456(2): 173-184.

Holz, G. G. (2004). "Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell." Diabetes 53(1): 5-13.

Hotamisligil, G. S. (2010). "Endoplasmic reticulum stress and the inflammatory basis of metabolic disease." Cell 140(6): 900-917.

Huang, S., R. Miao, Z. Zhou, T. Wang, J. Liu, G. Liu, Y. E. Chen, H. B. Xin, J.

Zhang and M. Fu (2013). "MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shock." Cell Signal 25(5): 1228-1234.

Hulme, M. A., C. H. Wasserfall, M. A. Atkinson and T. M. Brusko (2012). "Central role for interleukin-2 in type 1 diabetes." Diabetes 61(1): 14-22.

Hummel, K., K. K. McFann, J. Realsen, L. H. Messer, G. J. Klingensmith and H.

P. Chase (2012). "The increasing onset of type 1 diabetes in children." J Pediatr 161(4): 652-657 e651.

Hutton, J., C. Wasmeier, R. Amaria, N. Bright and J. Creemers (2004). "Proprotein processing and pancreatic islet function." Adv Exp Med Biol 552: 39-65.

Hutton, J. C. (1994). "Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases." Diabetologia 37 Suppl 2: S48-56.

Marjomaki, D. L. Eizirik, N. G. Morgan and S. J. Richardson (2018). "Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells." Diabetologia 61(11): 2344.

Ionescu-Tirgoviste, C., P. A. Gagniuc, E. Gubceac, L. Mardare, I. Popescu, S.

Dima and M. Militaru (2015). "A 3D map of the islet routes throughout the healthy human pancreas." Sci Rep 5: 14634.

Iynedjian, P. B. (1993). "Mammalian glucokinase and its gene." Biochem J 293 ( Pt 1):

1-13.

Jones, B., S. R. Bloom, T. Buenaventura, A. Tomas and G. A. Rutter (2018).

"Control of insulin secretion by GLP-1." Peptides 100: 75-84.

Jörns, A., M. Akin, T. Arndt, T. Terbish, A. M. Zu Vilsendorf, D. Wedekind, H. J.

Hedrich and S. Lenzen (2014). "Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by beta cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes." J Mol Med (Berl) 92(7): 743-755.

Jörns, A., T. Arndt, A. Meyer zu Vilsendorf, J. Klempnauer, D. Wedekind, H. J.

Hedrich, L. Marselli, P. Marchetti, N. Harada, Y. Nakaya, G. S. Wang, F. W.

Scott, C. Gysemans, C. Mathieu and S. Lenzen (2014). "Islet infiltration, cytokine

expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes." Diabetologia 57(3): 512-521.

Jörns, A., K. J. Rath, T. Terbish, T. Arndt, A. Meyer Zu Vilsendorf, D. Wedekind, H. J. Hedrich and S. Lenzen (2010). "Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation."

Endocrinology 151(8): 3555-3565.

Juan-Mateu, J., M. I. Alvelos, J. V. Turatsinze, O. Villate, E. Lizarraga-Mollinedo, F. A. Grieco, L. Marroqui, M. Bugliani, P. Marchetti and D. L. Eizirik (2018).

"SRp55 regulates a splicing network that controls human pancreatic beta-cell function and survival." Diabetes 67(3): 423-436.

Jura, J., P. Wegrzyn, M. Korostynski, K. Guzik, M. Oczko-Wojciechowska, M.

Jarzab, M. Kowalska, M. Piechota, R. Przewlocki and A. Koj (2008). "Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays." Biochim Biophys Acta 1779(6-7): 383-389.

Kacheva, S., S. Lenzen and E. Gurgul-Convey (2011). "Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide." Cytokine 55(2): 195-201.

Kagi, D., A. Ho, B. Odermatt, A. Zakarian, P. S. Ohashi and T. W. Mak (1999).

"TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes." J Immunol 162(8): 4598-4605.

Kahn, S. E. (2001). "Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes." J Clin Endocrinol Metab 86(9): 4047-4058.

Kahn, S. E. (2003). "The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes." Diabetologia 46(1): 3-19.

Kanak, M. A., M. Takita, F. Kunnathodi, M. C. Lawrence, M. F. Levy and B.

Naziruddin (2014). "Inflammatory response in islet transplantation." Int J Endocrinol 2014: 451035.

Kanayama, A., R. B. Seth, L. Sun, C. K. Ea, M. Hong, A. Shaito, Y. H. Chiu, L.

Deng and Z. J. Chen (2004). "TAB2 and TAB3 activate the NFB pathway through binding to polyubiquitin chains." Mol Cell 15(4): 535-548.

Kaplan, D. H., A. C. Greenlund, J. W. Tanner, A. S. Shaw and R. D. Schreiber (1996). "Identification of an interferon  receptor alpha chain sequence required for JAK-1 binding." J Biol Chem 271(1): 9-12.

Kawasaki, T. and T. Kawai (2014). "Toll-like receptor signaling pathways." Front Immunol 5: 461.

Kherra, S., J. L. Blouin, F. Santoni and V. Schwitzgebel (2017). "Precision medicine for monogenic diabetes: from a survey to the development of a next-generation diagnostic panel." Swiss Med Wkly 147: w14535.

Kim, K. A. and M. S. Lee (2009). "Recent progress in research on beta-cell apoptosis

Kim, K. A. and M. S. Lee (2009). "Recent progress in research on beta-cell apoptosis