6. R EFERENCES
7.6 List of putative transporters in M. pneumoniae
Tab. 7.7 Putative proteins involved in transmembrane transport processes in M. pneumoniae.
MPN # Gene name1,2 Essentiality3 Predicted Function1,2
MPN018 pmd1 F ATP-bind prot.; Multidrug resist. ABC transporter MPN019 msbA NE ATP-bind prot.; Multidrug resist. ABC transporter MPN043 glpF NE Glycerol facilitator
MPN048 NE Membrane export family
MPN049 NE Membrane export familiy
MPN055 potA E ATP-bind. protein for polyamine transport MPN056 potB E Transport permease (potB homolog)
MPN057 potI E Transport permease
MPN058 E Lipoprotein, transport system substrate-binding protein MPN076 NE Hypothetical protein, MFS transporter
MPN077 NE Hypothetical protein, MFS transporter MPN078 fruA F Permease EIIA/B/C component
MPN080 ybbP F ABC transporter membrane protein, FtsX-like permease MPN081 ybbA/ glnQ E ABC transporter ATP-binding protein
MPN095 NE Amino acid permease
MPN096 NE Amino acid permease
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MPN112 NE Permease
MPN113 NE Permease
MPN133 NE Lipoprotein / multiple sugar transport system substrate-binding protein / nuclease / MalE
MPN134 ugpC E Transport system permease, ATP binding protein MPN135 ugpA E Transport system (ABC transporter) permease MPN136 ugpE E Transport system (ABC transporter) permease
MPN193 cysA/cbiO1/ecfA1 F Energy-coupling factor transporter ATP-binding protein MPN194 hisP/cbiO2/ecfA2 E Energy-coupling factor transporter ATP-binding protein
MPN195 cbiQ F Transport protein
MPN207 ptsG E PTS system, glucose-specific EIIABC component MPN209 mgtA / pacL F Probable cation-transporting P-type ATPase MPN215 oppB E Peptide ABC transporter permease
MPN216 amiD / oppC F Peptide ABC transporter permease
MPN217 oppD E Peptide ABC transporter ATP-binding protein MPN218 oppF E Oligopeptide transport system ATP-binding protein,
hypothetical protein
MPN234 NE Membrane export family
MPN258 yjcW/mglA E Simple sugar ABC transporter, ATP-binding protein MPN259 NE Simple sugar ABC transporter permease
MPN260 rbsC F Simple sugar ABC transporter permease
MPN268 F PTS system component EIIB/EIIC domain-containing protein
MPN274 E ABC transporter permease
MPN308 apc NE Amino acid permease (sequence similarity zu mpn095/096)
MPN318 apc F Permease
MPN319 gap1 F permease
MPN333 NE Hypothetical membrane protein
MPN334 bcrA NE ABC transporter ATP binding protein (Multidrug-like transport?)
MPN335 NE Hypothetical membrane protein
MPN415 P37/ phnD F High-affinity transport system substrate-binding protein P37 MPN416 P29/ phnC F ABC transport system ATP-binding protein P29
MPN417 P69/ phnE F ABC transport system permease protein P69
MPN421 NE permease
MPN431 cbiQ E Transporter permease (CbiQ family)
MPN432 artP E Energy-coupling factor transporter ATP-binding protein MPN433 cbiO E Energy-coupling factor transporter ATP-binding protein
MPN435 E Permease
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E essential; F fitness; NE non-essential. 1 Himmelreich et al., 1996; 2 KEGG; 3 LLuch-Senar et al., in press.
MPN448 folT E Hypothetical protein, ECF transporter S component
MPN460 ktrB E KtrB, Trk-type K+ transport systems, membrane components, cation transporter
MPN461 ktrA E KtrA uptake protein, trk system potassium uptake protein TrkA MPN494 yjfU/ulaC (sgaA) F PTS system: ascorbate-specific EIIA component
MPN495 ulaB / sgaB NE PTS system: EIIB
MPN496 yjfU/sgaT/ulaA NE PTS system: ascorbate-specific EIIC component, similar to phosphotransferase protein for pentitol from E.coli, SGAT homolog
MPN508 NE Membrane export protein
MPN509 NE Membrane export protein
MPN510 F Membrane export protein
MPN511 NE Membrane export protein
MPN512 NE Membrane export protein
MPN571 lcnDR3 NE Hemolysin ABC transporter, ABC transporter ATP binding protein
MPN608 phoU / pstU NE Phosphate transport system, regulatory protein MPN609 pstB NE Phosphate import system, ATP-binding protein MPN610 pstA NE Phosphate ABC transport system, permease protein MPN611 pstS NE Phosphate transport system, substrate-binding protein MPN651 mtlA NE Similar to mannitol-specific PTS EIIBC, EIICB-Mtl MPN652 mtlD NE Mannitol-phosphate 5-dehydrogenase: D-mannitol
1-phosphate + NAD+ = D-fructose 6-1-phosphate + NADH MPN653 mtlF NE Mannitol-specific PTS system component EIIA MPN683 devA NE ABC transporter, ATP-binding protein
MPN684 F ABC transporter permease
MPN685 cysA F ABC transporter ATP-binding protein
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Curriculum vitae
STEPHANIE GROßHENNIG Rosenwinkel 22 37081 Göttingen Tel.: 0176/21896140 E-Mail: stgrosshennig@web.de
PERSONALINFORMATION
Name Stephanie Großhennig
Date of birth 04.05.1984 Place of birth Wernigerode
Nationality German
EDUCATION
Since 03/2012 Ph.D. thesis “Novel virulence determinants in Mycoplasma pneumoniae“ in the group of Prof. Dr. Jörg Stülke, Department of General Microbiology, Georg-August University Göttingen
11/2011 Master thesis “Transport systems in Mycoplasma pneumoniae“ in the group of Prof. Dr. Jörg Stülke, Department of General Microbiology, Georg-August University Göttingen
2009-2011 M.Sc. Studies of Microbiology and Biochemistry, Georg-August University Göttingen
08/2009 Bachelor thesis “Control of the intracellular glycerol-3-phosphate level in Mycoplasma pneumoniae – Influence of two homologous phosphodiesterases on the pathogenicity factor H2O2“ in the group of Prof. Dr. Jörg Stülke, Department of General Microbiology, Georg-August University Göttingen 2006-2009 B. Sc. Studies of Biology,
Georg-August University Göttingen
2004-2006 Studies of Landscape architecture, University Kassel 06/2003 Abitur, Heinrich-Heine-Gymnasium Ilsenburg
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INTERNSHIPS
09/2010-11/2010 Lab rotation about “Fascinating Facilitators: Analysis of Transporters in Mycoplasma pneumoniae” in the group of Prof. Dr. Jörg Stülke, Department of General Microbiology, Georg-August University Göttingen
12/2010-02/2011 Lab rotation on „Characterization of Aspergillus fumigatus ΔlaeA, ΔvelB, ΔvelC, and ΔvosA mutants” with Dr. Henriette Irmer,
Department for Molecular Microbiology and Genetics, Georg-August Universität Göttingen
02/2011-04/2011 Internship on “Analysis of listerial GpsB interactions with penicillin-binding proteins (PBPs) and construction of vectors for pbp gene replacement in Listeria monocytogenes” in the group of Dr. Sven Halbedel, FG 11 Bakterielle darmpathogene Erreger und Legionellen,
Robert-Koch-Institut Wernigerode
CONTRIBUTION TO CONFERENCES Presentation
10/2014 Microbiology and Infection2014, Gemeinsame Tagung der VAAM und DGHM, Dresden
Poster
12/2013 GGNB Poster session, Göttingen
3/2013 Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM), Bremen
PUBLICATION
Großhennig S, Schmidl SR, Schmeisky G, Busse J, Stülke J., 2013
Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence. Infect. Immun. March 2013 vol. 81 no. 3 896-904
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