4.5 Ausblick
4.5.1 Hormonell bedingte Neuroplastizität als möglicher Ansatzpunkt therapeutischer
Die Auswirkung der Hormone auf das menschliche Hirn bietet möglicherweise einen Ansatzpunkt medikamentöser Therapien von strukturellen Hirnerkrankungen. So wird im Rahmen der Alzheimer-Forschung die Hormonersatztherapie postmenopausaler Frauen als eine mögliche Therapieoption diskutiert, da das Krankheitsgeschehen durch den Abfall der zirkulierenden endogenen Östrogenkonzentration nach der Menopause möglicherweise negativ beeinflusst wird 55. Diese Hypothese wird durch neuroprotektive Effekte des Östrogens gestützt 93,94. Der Einsatz der Hormonersatztherapie zur
Prävention neurodegenerativer Prozesse im Alter ist aktuell Gegenstand kontroverser Diskussionen und findet lediglich sehr zurückhaltend Anwendung, da die Datenlage sehr heterogen ist. Bagger und Kollegen sowie Sherwin berichten von gemildertem
kognitiven Abbau im Alter bei zeitnaher Applikation der Hormonersatztherapie nach Beginn einer natürlichen oder induzierten Menopause 95,96. Demgegenüber stehen Ergebnisse, dass die Hormonersatztherapie das Risiko für die Entstehung einer dementiellen Erkrankung erhöht 97. Darüber hinaus wird der langfristigen Anwendung von exogen zugeführtem Östrogen ein negativer Effekt auf das Hippocampusvolumen zugeschrieben 98.
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Eidesstattliche Versicherung
„Ich, Philine Miriam Dolz, versichere an Eides statt durch meine eigenhändige Unterschrift, dass ich die vorgelegte Dissertation mit dem Thema: Eine Untersuchung der neuronalen Veränderungen durch die Einnahme oraler hormoneller Kontrazeptiva mit besonderem Fokus auf Veränderungen des Hippocampus selbstständig und ohne nicht offengelegte Hilfe Dritter verfasst und keine anderen als die angegebenen Quellen und Hilfsmittel genutzt habe.
Alle Stellen, die wörtlich oder dem Sinne nach auf Publikationen oder Vorträgen anderer Autoren beruhen, sind als solche in korrekter Zitierung (siehe „Uniform Requirements for Manuscripts (URM)“ des ICMJE -www.icmje.org) kenntlich gemacht. Die Abschnitte zu Methodik (insbesondere praktische Arbeiten, Laborbestimmungen, statistische Aufarbeitung) und Resultaten (insbesondere Abbildungen, Graphiken und Tabellen) entsprechen den URM (s.o) und werden von mir verantwortet.
Meine Anteile an etwaigen Publikationen zu dieser Dissertation entsprechen denen, die in der untenstehenden gemeinsamen Erklärung mit dem/der Betreuer/in, angegeben sind. Sämtliche Publikationen, die aus dieser Dissertation hervorgegangen sind und bei denen ich Autor bin, entsprechen den URM (s.o) und werden von mir verantwortet.
Die Bedeutung dieser eidesstattlichen Versicherung und die strafrechtlichen Folgen einer unwahren eidesstattlichen Versicherung (§156,161 des Strafgesetzbuches) sind mir bekannt und bewusst.“
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