Conclusions - General Discussion - Synaptically evoked input-output functions in auditory brain

6. General Discussion

6.8. Conclusions

Late postnatal development tunes the membrane properties of auditory brainstem neurons in distinct patterns, according to their function in the neuronal circuit. The VNLL and MNTB receive large glutamatergic inputs that are converted to temporally precise glycinergic output with high fidelity, and a single input can potentially drive them even during high frequency stimulations. The MSO substantially decreases its input resistance, upregulates voltage-gated potassium, and hyperpolarization-activated and cyclic nucleotide-gated channels, as well as decreases its calcium signaling, in order to detect coincident events with minimal arrival time differences. The DNLL integrates over a larger time window and is highly excitable. Therefore, it relays onset sounds efficiently and temporally integrates high frequency inputs.

Thus, we have demonstrated a relationship between structure and function in auditory brainstem nuclei and have shown that distinct cellular properties modulate input-output functions.

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Im Dokument Synaptically evoked input-output functions in auditory brainstem nuclei (Seite 71-86)