• Keine Ergebnisse gefunden

Adams,& P.D.,& Afonine,& P.V.,& Bunkoczi,& G.,& Chen,& V.B.,& Davis,& I.W.,& Echols,& N.,&

Headd,& J.J.,& Hung,& L.W.,& Kapral,& G.J.,& Grosse:Kunstleve,& R.W.,' et' al.& (2010).&

PHENIX:& a& comprehensive& Python:based& system& for& macromolecular& structure&

solution.& Acta& crystallographica& Section& D,& Biological& crystallography' 66,& 213:

221.&

&

Afonine,& P.V.,& Grosse:Kunstleve,& R.W.,& Echols,& N.,& Headd,& J.J.,& Moriarty,& N.W.,&

Mustyakimov,& M.,& Terwilliger,& T.C.,& Urzhumtsev,& A.,& Zwart,& P.H.,& and& Adams,&

P.D.& (2012).& Towards& automated& crystallographic& structure& refinement& with&

phenix.refine.& Acta& crystallographica& Section& D,& Biological& crystallography' 68,&

352:367.&

&

Akimoto,&M.,&Selvaratnam,&R.,&McNicholl,&E.T.,&Verma,&G.,&Taylor,&S.S.,&and&Melacini,&

G.&(2013).&Signaling&through&dynamic&linkers&as&revealed&by&PKA.&Proceedings&of&

the&National&Academy&of&Sciences&of&the&United&States&of&America'110,&14231:

14236.&

&

Alderton,& W.K.,& Cooper,& C.E.,& and& Knowles,& R.G.& (2001).& Nitric& oxide& synthases:&

structure,&function&and&inhibition.&The&Biochemical&journal'357,&593:615.&

&

Alverdi,&V.,&Mazon,&H.,&Versluis,&C.,&Hemrika,&W.,&Esposito,&G.,&van&den&Heuvel,&R.,&

Scholten,& A.,& and& Heck,& A.J.& (2008).& cGMP:binding& prepares& PKG& for& substrate&

binding& by& disclosing& the& C:terminal& domain.& Journal& of& molecular& biology' 375,&

1380:1393.&

&

An,&S.Q.,&Chin,&K.H.,&Febrer,&M.,&McCarthy,&Y.,&Yang,&J.G.,&Liu,&C.L.,&Swarbreck,&D.,&

Rogers,&J.,&Maxwell&Dow,&J.,&Chou,&S.H.,'et'al.&(2013).&A&cyclic&GMP:dependent&

signalling& pathway& regulates& bacterial& phytopathogenesis.& EMBO& J' 32,& 2430:

2438.&

&

Arnold,& W.P.,& Mittal,& C.K.,& Katsuki,& S.,& and& Murad,& F.& (1977).& Nitric& oxide& activates&

guanylate&cyclase&and&increases&guanosine&3':5':cyclic&monophosphate&levels&in&

various&tissue&preparations.&Proceedings&of&the&National&Academy&of&Sciences&of&

the&United&States&of&America'74,&3203:3207.&

&

Beavo,& J.A.,& and& Brunton,& L.L.& (2002).& Cyclic& nucleotide& research& ::& still& expanding&

after&half&a&century.&Nature&reviews&Molecular&cell&biology'3,&710:718.&

&

Beckman,& J.S.,& and& Koppenol,& W.H.& (1996).& Nitric& oxide,& superoxide,& and&

peroxynitrite:& the& good,& the& bad,& and& ugly.& The& American& journal& of& physiology' 271,&C1424:1437.&

&

Bender,& A.T.,& and& Beavo,& J.A.& (2006).& Cyclic& nucleotide& phosphodiesterases:&

molecular&regulation&to&clinical&use.&Pharmacological&reviews'58,&488:520.&

&

Berman,&H.M.,&Ten&Eyck,&L.F.,&Goodsell,&D.S.,&Haste,&N.M.,&Kornev,&A.,&and&Taylor,&

S.S.& (2005).& The& cAMP& binding& domain:& an& ancient& signaling& module.&

Proceedings& of& the& National& Academy& of& Sciences& of& the& United& States& of&

America'102,&45:50.&

&

&

Bos,&J.L.&(2006).&Epac&proteins:&multi:purpose&cAMP&targets.&Trends&in&biochemical&

sciences'31,&680:686.&

&

Bredt,&D.S.,&Hwang,&P.M.,&Glatt,&C.E.,&Lowenstein,&C.,&Reed,&R.R.,&and&Snyder,&S.H.&

(1991).& Cloned& and& expressed& nitric& oxide& synthase& structurally& resembles&

cytochrome&P:450&reductase.&Nature'351,&714:718.&

&

Brelidze,&T.I.,&Carlson,&A.E.,&Sankaran,&B.,&and&Zagotta,&W.N.&(2012).&Structure&of&the&

carboxy:terminal&region&of&a&KCNH&channel.&Nature'481,&530:533.&

&

Brelidze,& T.I.,& Gianulis,& E.C.,& DiMaio,& F.,& Trudeau,& M.C.,& and& Zagotta,& W.N.& (2013).&

Structure&of&the&C:terminal&region&of&an&ERG&channel&and&functional&implications.&

Proceedings& of& the& National& Academy& of& Sciences& of& the& United& States& of&

America'110,&11648:11653.&

&

Bruystens,& J.G.,& Wu,& J.,& Fortezzo,& A.,& Kornev,& A.P.,& Blumenthal,& D.K.,& and& Taylor,&

S.S.& (2014).& PKA& RIalpha& homodimer& structure& reveals& an& intermolecular&

interface& with& implications& for& cooperative& cAMP& binding& and& Carney& complex&

disease.&Structure'22,&59:69.&

&

Burette,&A.,&Zabel,&U.,&Weinberg,&R.J.,&Schmidt,&H.H.,&and&Valtschanoff,&J.G.&(2002).&

Synaptic&localization&of&nitric&oxide&synthase&and&soluble&guanylyl&cyclase&in&the&

hippocampus.&The&Journal&of&neuroscience&:&the&official&journal&of&the&Society&for&

Neuroscience'22,&8961:8970.&

&

Burgoyne,&J.R.,&Madhani,&M.,&Cuello,&F.,&Charles,&R.L.,&Brennan,&J.P.,&Schroder,&E.,&

Browning,&D.D.,&and&Eaton,&P.&(2007).&Cysteine&redox&sensor&in&PKGIa&enables&

oxidant:induced&activation.&Science'317,&1393:1397.&

&

Busch,&J.L.,&Bessay,&E.P.,&Francis,&S.H.,&and&Corbin,&J.D.&(2002).&A&conserved&serine&

juxtaposed&to&the&pseudosubstrate&site&of&type&I&cGMP:dependent&protein&kinase&

contributes& strongly& to& autoinhibition& and& lower& cGMP& affinity.& The& Journal& of&

biological&chemistry'277,&34048:34054.&

&

Busker,& M.,& Neidhardt,& I.,& and& Behrends,& S.& (2014).& Nitric& oxide& activation& of&

guanylate&cyclase&pushes&the&alpha1&signaling&helix&and&the&beta1&heme:binding&

domain& closer& to& the& substrate:binding& site.& The& Journal& of& biological& chemistry' 289,&476:484.&

&

Büssow,&K.,&Quedenau,&C.,&Sievert,&V.,&Tischer,&J.,&Scheich,&C.,&Seitz,&H.,&Hieke,&B.,&

Niesen,& F.H.,& Götz,& F.,& Harttig,& U.,' et' al.& (2004).& A& catalog& of& human& cDNA&

expression& clones& and& its& application& to& structural& genomics.& Genome& Biol' 5,&

R71.&

&

Büssow,& K.,& Scheich,& C.,& Sievert,& V.,& Harttig,& U.,& Schultz,& J.,& Simon,& B.,& Bork,& P.,&

Lehrach,&H.,&and&Heinemann,&U.&(2005).&Structural&genomics&of&human&proteins::

target& selection& and& generation& of& a& public& catalogue& of& expression& clones.&

Microbial&cell&factories'4,&21.&

&

Butt,&E.,&Abel,&K.,&Krieger,&M.,&Palm,&D.,&Hoppe,&V.,&Hoppe,&J.,&and&Walter,&U.&(1994).&

cAMP:& and& cGMP:dependent& protein& kinase& phosphorylation& sites& of& the& focal&

adhesion& vasodilator:stimulated& phosphoprotein& (VASP)& in& vitro& and& in& intact&

human&platelets.&The&Journal&of&biological&chemistry'269,&14509:14517.&

&

Campbell,& M.G.,& Underbakke,& E.S.,& Potter,& C.S.,& Carragher,& B.,& and& Marletta,& M.A.&

(2014).&Single:particle&EM&reveals&the&higher:order&domain&architecture&of&soluble&

guanylate& cyclase.& Proceedings& of& the& National& Academy& of& Sciences& of& the&

United&States&of&America'111,&2960:2965.&

&

Carnicer,& R.,& Crabtree,& M.J.,& Sivakumaran,& V.,& Casadei,& B.,& and& Kass,& D.A.& (2013).&

Nitric& oxide& synthases& in& heart& failure.& Antioxidants& && redox& signaling' 18,& 1078:

1099.&

&

Casteel,&D.E.,&Smith:Nguyen,&E.V.,&Sankaran,&B.,&Roh,&S.H.,&Pilz,&R.B.,&and&Kim,&C.&

(2010).& A& crystal& structure& of& the& cyclic& GMP:dependent& protein& kinase& I{beta}&

dimerization/docking& domain& reveals& molecular& details& of& isoform:specific&

anchoring.&The&Journal&of&biological&chemistry'285,&32684:32688.&

&

Casteel,&D.E.,&Zhang,&T.,&Zhuang,&S.,&and&Pilz,&R.B.&(2008).&cGMP:dependent&protein&

kinase&anchoring&by&IRAG&regulates&its&nuclear&translocation&and&transcriptional&

activity.&Cellular&signalling'20,&1392:1399.&

&

Chang,&D.F.,&Belaguli,&N.S.,&Chang,&J.,&and&Schwartz,&R.J.&(2007).&LIM:only&protein,&

CRP2,& switched& on& smooth& muscle& gene& activity& in& adult& cardiac& myocytes.&

Proceedings& of& the& National& Academy& of& Sciences& of& the& United& States& of&

America'104,&157:162.&

&

Charles,& I.G.,& Palmer,& R.M.,& Hickery,& M.S.,& Bayliss,& M.T.,& Chubb,& A.P.,& Hall,& V.S.,&

Moss,&D.W.,&and&Moncada,&S.&(1993).&Cloning,&characterization,&and&expression&

of& a& cDNA& encoding& an& inducible& nitric& oxide& synthase& from& the& human&

chondrocyte.& Proceedings& of& the& National& Academy& of& Sciences& of& the& United&

States&of&America'90,&11419:11423.&

&

Chayen,&N.D.,&Shaw&Stewart,&P.D.,&and&Blow,&D.M.&(1992).&Microbatch&crystallization&

under& oil& —& a& new& technique& allowing& many& small:volume& crystallization& trials.&

Journal&of&Crystal&Growth&122,&176:180.&

&

Chayen,&N.E.,&and&Saridakis,&E.&(2008).&Protein&crystallization:&from&purified&protein&

to&diffraction:quality&crystal.&Nature&methods'5,&147:153.&

&

Corbin,&J.D.,&and&Døskeland,&S.O.&(1983).&Studies&of&two&different&intrachain&cGMP:

binding& sites& of& cGMP:dependent& protein& kinase.& The& Journal& of& biological&

chemistry'258,&11391:11397.&

&

Corbin,& J.D.,& Ogreid,& D.,& Miller,& J.P.,& Suva,& R.H.,& Jastorff,& B.,& and& Doskeland,& S.O.&

(1986).& Studies& of& cGMP& analog& specificity& and& function& of& the& two& intrasubunit&

binding& sites& of& cGMP:dependent& protein& kinase.& The& Journal& of& biological&

chemistry'261,&1208:1214.&

&

Corbin,& J.D.,& Turko,& I.V.,& Beasley,& A.,& and& Francis,& S.H.& (2000).& Phosphorylation& of&

phosphodiesterase:5& by& cyclic& nucleotide:dependent& protein& kinase& alters& its&

catalytic&and&allosteric&cGMP:binding&activities.&Eur&J&Biochem'267,&2760:2767.&

&

Cordes,&T.J.,&Worzalla,&G.A.,&Ginster,&A.M.,&and&Forest,&K.T.&(2011).&Crystal&structure&

of& the& Pseudomonas& aeruginosa& virulence& factor& regulator.& Journal& of&

bacteriology'193,&4069:4074.&

&

Craven,& K.B.,& and& Zagotta,& W.N.& (2006).& CNG& and& HCN& channels:& two& peas,& one&

pod.&Annu&Rev&Physiol'68,&375:401.&

&

Cummings,& M.D.,& Farnum,& M.A.,& and& Nelen,& M.I.& (2006).& Universal& screening&

methods&and&applications&of&ThermoFluor.&J&Biomol&Screen'11,&854:863.&

&

Derbyshire,& E.R.,& and& Marletta,& M.A.& (2012).& Structure& and& regulation& of& soluble&

guanylate&cyclase.&Annual&review&of&biochemistry'81,&533:559.&

&

Diller,&T.C.,&Madhusudan,&Xuong,&N.H.,&and&Taylor,&S.S.&(2001).&Molecular&basis&for&

regulatory& subunit& diversity& in& cAMP:dependent& protein& kinase:& crystal& structure&

of&the&type&II&beta&regulatory&subunit.&Structure'9,&73:82.&

&

Døskeland,& S.O.,& Maronde,& E.,& and& Gjertsen,& B.T.& (1993).& The& genetic& subtypes& of&

cAMP:dependent& protein& kinase::functionally& different& or& redundant?& Biochimica&

et&biophysica&acta'1178,&249:258.&

&

Ellerbroek,& S.M.,& Wennerberg,& K.,& and& Burridge,& K.& (2003).& Serine& phosphorylation&

negatively& regulates& RhoA& in& vivo.& The& Journal& of& biological& chemistry' 278,&

19023:19031.&

&

Emsley,& P.,& and& Cowtan,& K.& (2004).& Coot:& model:building& tools& for& molecular&

graphics.& Acta& crystallographica& Section& D,& Biological& crystallography' 60,& 2126:

2132.&

&

Emsley,& P.,& Lohkamp,& B.,& Scott,& W.G.,& and& Cowtan,& K.& (2010).& Features& and&

development&of&Coot.&Acta&crystallographica&Section&D,&Biological&crystallography' 66,&486:501.&

&

Endicott,&J.A.,&Noble,&M.E.,&and&Johnson,&L.N.&(2012).&The&structural&basis&for&control&

of&eukaryotic&protein&kinases.&Annual&review&of&biochemistry'81,&587:613.&

&

Erdmann,& E.,& Semigran,& M.J.,& Nieminen,& M.S.,& Gheorghiade,& M.,& Agrawal,& R.,&

Mitrovic,& V.,& and& Mebazaa,& A.& (2013a).& Cinaciguat,& a& soluble& guanylate& cyclase&

activator,& unloads& the& heart& but& also& causes& hypotension& in& acute&

decompensated&heart&failure.&European&heart&journal'34,&57:67.&

&

Erdmann,&J.,&Stark,&K.,&Esslinger,&U.B.,&Rumpf,&P.M.,&Koesling,&D.,&de&Wit,&C.,&Kaiser,&

F.J.,& Braunholz,& D.,& Medack,& A.,& Fischer,& M.,' et' al.& (2013b).& Dysfunctional& nitric&

oxide&signalling&increases&risk&of&myocardial&infarction.&Nature'504,&432:436.&

&

Evgenov,& O.V.,& Pacher,& P.,& Schmidt,& P.M.,& Hasko,& G.,& Schmidt,& H.H.,& and& Stasch,&

J.P.& (2006).& NO:independent& stimulators& and& activators& of& soluble& guanylate&

cyclase:& discovery& and& therapeutic& potential.& Nature& reviews& Drug& discovery' 5,&

755:768.&

&

Fazakerley,& G.V.,& Russell,& J.C.,& and& Wolfe,& M.A.& (1977).& Determination& of& the& syn:

anti& equilibrium& of& some& purine& 3':5':nucleotides& by& nuclear:magnetic:relaxation&

perturbation& in& the& presence& of& a& lanthanide:ion& probe.& Eur& J& Biochem' 76,& 601:

605.&

&

Feil,& R.,& Kellermann,& J.,& and& Hofmann,& F.& (1995).& Functional& cGMP:dependent&

protein& kinase& is& phosphorylated& in& its& catalytic& domain& at& threonine:516.&

Biochemistry'34,&13152:13158.&

&

Francis,& S.H.,& Blount,& M.A.,& and& Corbin,& J.D.& (2011).& Mammalian& cyclic& nucleotide&

phosphodiesterases:& molecular& mechanisms& and& physiological& functions.&

Physiological&reviews'91,&651:690.&

&

Francis,& S.H.,& Busch,& J.L.,& Corbin,& J.D.,& and& Sibley,& D.& (2010).& cGMP:dependent&

protein&kinases&and&cGMP&phosphodiesterases&in&nitric&oxide&and&cGMP&action.&

Pharmacological&reviews'62,&525:563.&

&

Francis,&S.H.,&and&Corbin,&J.D.&(1999).&Cyclic&nucleotide:dependent&protein&kinases:&

intracellular& receptors& for& cAMP& and& cGMP& action.& Critical& reviews& in& clinical&

laboratory&sciences'36,&275:328.&

&

Francis,& S.H.,& Poteet:Smith,& C.,& Busch,& J.L.,& Richie:Jannetta,& R.,& and& Corbin,& J.D.&

(2002).& Mechanisms& of& autoinhibition& in& cyclic& nucleotide:dependent& protein&

kinases.&Frontiers&in&bioscience&:&a&journal&and&virtual&library'7,&d580:592.&

&

Fukao,& M.,& Mason,& H.S.,& Britton,& F.C.,& Kenyon,& J.L.,& Horowitz,& B.,& and& Keef,& K.D.&

(1999).& Cyclic& GMP:dependent& protein& kinase& activates& cloned& BKCa& channels&

expressed& in& mammalian& cells& by& direct& phosphorylation& at& serine& 1072.& The&

Journal&of&biological&chemistry'274,&10927:10935.&

&

Furchgott,&R.F.,&and&Zawadzki,&J.V.&(1980).&The&obligatory&role&of&endothelial&cells&in&

the&relaxation&of&arterial&smooth&muscle&by&acetylcholine.&Nature'288,&373:376.&

&

Gamm,&D.M.,&Francis,&S.H.,&Angelotti,&T.P.,&Corbin,&J.D.,&and&Uhler,&M.D.&(1995).&The&

type& II& isoform& of& cGMP:dependent& protein& kinase& is& dimeric& and& possesses&

regulatory&and&catalytic&properties&distinct&from&the&type&I&isoforms.&The&Journal&of&

biological&chemistry'270,&27380:27388.&

&

Gasteiger,&E.,&Hoogland,&C.,&Gattiker,&A.,&Duvaud,&S.,&Wilkins,&M.R.,&Appel,&R.D.,&and&

Bairoch,& A.& (2005).& Protein& Identification& and& Analysis& Tools& on& the& ExPASy&

Server&(Humana&Press).&

&

Geiselhöringer,&A.,&Werner,&M.,&Sigl,&K.,&Smital,&P.,&Worner,&R.,&Acheo,&L.,&Stieber,&J.,&

Weinmeister,&P.,&Feil,&R.,&Feil,&S.,'et'al.&(2004).&IRAG&is&essential&for&relaxation&of&

receptor:triggered& smooth& muscle& contraction& by& cGMP& kinase.& EMBO& J' 23,&

4222:4231.&

&

Ghofrani,&H.A.,&D'Armini,&A.M.,&Grimminger,&F.,&Hoeper,&M.M.,&Jansa,&P.,&Kim,&N.H.,&

Mayer,&E.,&Simonneau,&G.,&Wilkins,&M.R.,&Fritsch,&A.,'et'al.&(2013a).&Riociguat&for&

the& treatment& of& chronic& thromboembolic& pulmonary& hypertension.& The& New&

England&journal&of&medicine'369,&319:329.&

&

Ghofrani,&H.A.,&Osterloh,&I.H.,&and&Grimminger,&F.&(2006).&Sildenafil:&from&angina&to&

erectile&dysfunction&to&pulmonary&hypertension&and&beyond.&Nature&reviews&Drug&

discovery'5,&689:702.&

&

Ghofrani,& H.A.,& Simonneau,& G.,& Rubin,& L.J.,& Authors& of,& C.,& and& Patent& (2013b).&

Riociguat&for&pulmonary&hypertension.&The&New&England&journal&of&medicine'369,&

2268.&

&