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Acknowledgements
I would like to express my deep gratitude to my research supervisor Prof. Dr. med. F. Ihler for giving me the opportunity to do research and providing guidance throughout this project. I am extending my sincere thanks to my second supervisor Prof. Dr. med. T. Buhl for his motivation and insightful comments.
My special thanks goes to my friend and colleague Dr. med. Eirini Mavropoulou for her continuing support to complete this research work. I would like to thank Dr. med. Moritz Hollstein for his technical support and Dr. med. Ismini Papageorgiou for her radiological assistance.