Recently, since vaccine resistant strains of Y. ruckeri were isolated on some incidents from trout hatcheries in North West Germany, an epidemiological survey on the occurrence and
Chapter 1 Introduction
22
phenotypic/molecular characterization of Y. ruckeri strains from trout hatcheries in North West Germany was planned.
The aims of the study are:
To provide data on the distribution of Y. ruckeri strains in rainbow trout hatcheries and correlate this to outbreaks of ERM in the farms.
To study the diversity of both biochemical and molecular characteristics of Y. ruckeri isolates from North West Germany.
To find out the relationship between the fatty acid composition of Y. ruckeri isolates and the epidemiological characters
To detect in vitro cytotoxicity of both motile and non-motile strains of Y. ruckeri under different conditions, e.g. temperature and time.
To study virulence factor genes and their expression in collected Y. ruckeri isolates which would provide a basic virulent background of these North West Germany isolates.
To test the antimicrobial susceptibility of collected isolates and offer more data on antimicrobial resistant Y. ruckeri isolates.
It would allow the development of a concept for strategic, preventive health monitoring in fish farms on the basis of risk analysis. It would be also helpful with identifying and characterizing pathogenic Y. ruckeri strains and examine the distribution of these strains in the field as a basis for preventive disease monitoring plans.
Chapter 1 Introduction
23
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