VolaƟ le Organic Compounds in
Chronic ObstrucƟ ve Pulmonary Disease
* Korea InsƟ tute of Science and Technology Europe ForschungsgesellschaŌ mbH (KIST Europe) Campus E 7 1 - 66123 Saarbrücken - Germany
phone + 49 (0) 681 9382 229 - fax + 49 (0) 681 9382 240
hƩ p://www.kist-europe/r_cd_jibb.html hƩ p://www.kist-europe.com
hƩ p://www.kist-europe.de
Contact: PD Dr. Jörg Ingo Baumbach
Head of Department Microfl uidics and Clinical DiagnosƟ cs baumbach@kist-europe.de
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V. Besa 1 , K. Darwiche 1 , H. Teschler 1 , I.Kurth 1 , T. Rabis 1 , O.Anhenn 1 , U. Sommerwerck 1 , J.I. Baumbach 2,3 , L. Freitag 2
1 Ruhrlandklinik, Clinic for Pulmonology, University Hospital Essen, Tüschener Weg 40, 45239 Essen, Germany 2 KIST Europe, Department Microfl uidics and Clinical DiagnosƟ cs, Campus E 71, 66123 Saarbrücken, Germany
3 B&S AnalyƟ k, BioMedicalCenter Dortmund, OƩ o-Hahn-Str. 15, 44227 Dortmund, Germany
Acknowledgements The fi nancial support of the Ministry of Educa on,
Science and Technology (MEST) of the Republic Korea is acknowledged thankfully. Part of the work on this paper has been supported by Deutsche For- schungsgemeinscha (DFG) within the Collabora - ve Research Center (Sonderforschungsbereich) SFB 876 „Providing Informa on by Resource-Constrai- ned Analysis“, project TB1 “Resource-Constrained
Analysis of Spectrometry Data“.
In addi on, the work was supported partly by the German Federal Ministry of Economics and Tech- nology based on a decision of the German Bundes-
tag within the project KF2368102AKO.
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Chronic obstruc ve pulmona-
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the gold-standard in the diagnosis of the disease and
Forced Expiratory Volume in 1 second (FEV1) is used to gra- de the severity of the disease and is the strongest predictor of
the mortality in these pa ents. However, COPD pa ents have sys- temic infl amma on that is not actually refl ected by FEV1. The analysis
of breath air is not a new concept. Vola le organic compounds (VOC) are un l now inves gated by several methods in lung diseases, such as airway infec ons, lung cancer, sarcoidosis, asthma and COPD. In our study we used the technology of the ion mobility spectrometry to detect VOCs in the exhaled breath of pa ents with COPD. The ion mobili- ty spectrometry allows a non-invasive, easy and fast detec on of VOCs and especially in very low concentra ons. The purpose of this study was to iden fy peaks of VOCs that could discri-
minate COPD pa ents from healthy subjects as well as to determine whether specifi c VOC peaks could
diff eren ate COPD pa ents with diff e- rent severity groups.
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tag wwwithinithinithinithinithinithinithinithinithinithinithinithinithinitiththinhinthe the the the the the the the the the the the the the theprojeprojeprojeprojeprojeprojeprojeprojeprojeprojeprojeprojeprojeprojeprojeppror ct KFct KFct KFct KFct KFct KFct KFct KFct KFct KFct KFct KFct KFct KFct KFKK23681236812368123681236823681236812368123682368123681236812368236823682323802AKO02AKO02AKO02AKO02AKO02AKO02AKO02A02AKO02AKO02AKO02AKO02AKO02AKO02AKO...
