HO HN

In some cases, the natural products itself made it to market (e.g. penicillin, fosfomycin, streptomycin, erythromycin, vancomycin, chlorotetracycline), in others semisynthetic

Herein we describe a catalytic asymmetric total synthesis ()–perophoramidine (1) based on a different strategy, which utilizes a molybdenum-catalyzed asymmetric allylic

In a first fruitful synthetic sequence (Scheme �-��), allyl bromide ��� was reacted with hexam- ethylenetetramine and transformed into quaternary ammonium salt ��� which

After 45 minutes, the yellow suspension was poured into a mixture of 10 mL saturated aqueous sodium bicarbonate solution and 10 mL saturated aqueous sodium thiosulfate

a Department of Neuroscience and Medical Research Institute, College of Medicine, Ewha Womans University, Ewha Global Challenge BK21, Seoul 158-710, South Korea. b Union

The organic phase was separated, washed with a saturated aqueous NH 4 Cl solution (10 mL), dried over an- hydrous MgSO 4 and concentrated under reduced pressure.. The residue

E-mail: wolfgang.voelter@uni-tuebingen.de Dedicated to Professor Ge´rard Descotes, Universite´ Claude Bernard, Lyon 1, France Z.. 56 b, 325Ð328 (2001); received December

Subjection of this material to flash chromatography (19:1 pentane/EtOAc) and concentration of the appropriate fractions afforded methyl ether 152 (130 mg, 0.28 mmol, 87%) as