Heterogeneity in astrocyte responses after acute injury in vitro and in vivo
99
0
0
Volltext
(2)
(3)
(4)
(5) !"! #$% .
(6)
(7)
(8)
(9) "
(10) %&'"
(11) (
(12) ) *"!!!+ % ,(
(13)
(14) " -./0. .
(15)
(16) !
(17) " #
(18) $ . 1
(19) !"! #$%. 2
(20) !"!3 # 4. "(
(21) !"!!"! !! 3 5,635,363 7 -.!89'-./0. .
(22) %
(23)
(24) &
(25) ( & 5
(26) "
(27) ' 5 4'( : ' &( 5 8 %
(28) '
(29) 5
(30) ( :( 1% , % '! ( ; 5
(31) "
(32)
(33) ,
(34) ' 8 %& ( # ! . . . X. 5. . . . .
(35) . .
(36)
(37) 9 <
(38) 9
(39) 9
(40)
(41) ' ! 7
(42)
(43)
(44)
(45)
(46)
(47) *6)8+ 9
(48)
(49)
(50)
(51)
(52) !
(53) 5 (
(54) '
(55)
(56)
(57)
(58) 9
(59)
(60)
(61)
(62) ! 6)8 <
(63)
(64)
(65) 5
(66) =
(67)
(68) >5 %'
(69) 9
(70)
(71)
(72) 9
(73) 9 5 9
(74) %
(75) 5
(76) 9
(77)
(78) ! 8
(79) 5 (
(80)
(81)
(82) 5
(83)
(84) 9 '9
(85) 9
(86)
(87)
(88) 9
(89) 9 9 ! 8
(90) ? 59
(91)
(92)
(93)
(94) 99 9
(95) < 5
(96) '
(97) ? 9
(98) ! :
(99) 5
(100)
(101) ' < 5!!9
(102)
(103)
(104) 5
(105) ' !,
(106) 5 ' -9
(107)
(108)
(109)
(110) 9 *-98+
(111)
(112)
(113)
(114) #, '
(115)
(116) (
(117) '
(118) < ! 7
(119) 9
(120)
(121)
(122)
(123) ?
(124) 5
(125) '
(126)
(127)
(128) '
(129)
(130)
(131) 9
(132)
(133) %! " '
(134)
(135) ' 9
(136) 9 5 9
(137) % @
(138) 5'
(139) < ! 5 (
(140)
(141)
(142)
(143)
(144)
(145)
(146)
(147) '9 '
(148) 5'
(149) (
(150)
(151)
(152)
(153)
(154) !
(155) 5 9
(156)
(157) '
(158)
(159) < 9
(160)
(161) 9
(162) 9 < ! ;
(163) 9
(164)
(165) '
(166)
(167)
(168)
(169) 3
(170) #7 6A- B (
(171)
(172) 9
(173) B5 95 <
(174) ?
(175) 9
(176)
(177) < ! ,
(178)
(179) '
(180)
(181) .
(182)
(183) '
(184)
(185)
(186)
(187) ' 9
(188) 9
(189)
(190)
(191)
(192)
(193) 6A-
(194) < ! 7
(195)
(196) 9
(197)
(198)
(199)
(200)
(201) ' 9
(202)
(203)
(204) 9
(205)
(206)
(207) 9
(208) 5 <
(209) 5 9
(210)
(211)
(212) ' 6)8!. .
(213) '
(214)
(215)
(216)
(217) % ' $4 #99
(218) # % # 8 ! " :
(219)
(220)
(221) % 3
(222) % ) *2)8+5
(223) 9
(224)
(225) ,(
(226) !: "
(227) % 3(
(228) 9
(229)
(230) 1 ' <% ! ,
(231) % 2)8
(232) % '
(233) (
(234) 9
(235)
(236) : 9
(237) 9 5
(238) 5 ; :
(239)
(240) ' ! " C( #
(241) D% !" ' (# % 5 9
(242)
(243)
(244) % #
(245) 4 % % 5 2 % ( % '% 8% % ! & ' '(5
(246) '
(247) % % 5
(248)
(249) ' 7 9
(250) 9
(251) % ! ; 5 %
(252)
(253) % ( % 5 %!1!
(254)
(255) ;5 ' ! " '
(256) ,
(257) %%(
(258) % # ( (
(259) ( % ' 2 -
(260)
(261) (
(262) (
(263) 9 ! " 1
(264) ' %
(265) 9
(266)
(267)
(268) (
(269) % 5 ! !. 9
(270) 9 59
(271)
(272) % ' (
(273)
(274) $4! #% % 8 5
(275) '(
(276) 7 9
(277) # % 5 ;
(278)
(279) % % E % '
(280) ' ! (5 ( 7 9
(281) 9
(282)
(283)
(284) % 5
(285) (F
(286) ( 1 4*<( + !8 ' 3
(287) #7 6A- B 8 (
(288) 2 9
(289) B5 %
(290)
(291) (
(292) % 5' ' ( ) ! %
(293) % .
(294) %
(295) %
(296) (5 '
(297) ; 2 ! 8
(298) 5 9 6A- 8 3
(299) 3(
(300)
(301)
(302) % ( % " 9 8 '% (
(303) % 1% 3
(304) )'' 3
(305)
(306) : ' ' ! '
(307) &( ' 7 9
(308) 9
(309)
(310)
(311) % ,(
(312)
(313) ! : ' (
(314)
(315) <( 9
(316)
(317) % : %
(318) % %9
(319) !. .
(320) ( )
(321) * + ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,* /!/. #
(322) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!/. /!-.
(323)
(324) ' 9
(325)
(326) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!A. /!-!/ /!0. #
(327) '
(328)
(329) ' ' !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!G.
(330)
(331) 9
(332)
(333)
(334)
(335) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!H. /!0!/. 3
(336) #76A- (
(337)
(338) 9
(339) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!/-. /!0!-.
(340) '9
(341) 9
(342) 9
(343) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!/0. /!0!0. 8'
(344) < B
(345)
(346) ' < !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!/A . /!A. 7
(347)
(348)
(349)
(350) !!!!!!!!!!!!!!!!!!!!!!!!/I. /!I. 7
(351) 9
(352)
(353)
(354)
(355) 9
(356)
(357) ' !!!!!!!!!!!!!!!!!/G. -. .
(358) ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,*/. 0. 1
(359)
(360) ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,-2 0!/. 7
(361)
(362) 3
(363) #76A-
(364)
(365) < !!!!!!!!!!!!!!!!!!!!!!-.. 0!-.
(366)
(367) 9
(368)
(369) ' < !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!0A. 3. 4
(370)
(371)
(372) ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,56 A!/. :
(373)
(374)
(375) < !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!IH . A!-.
(376)
(377) < !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!G.. A!0.
(378) 9
(379)
(380) < 9
(381)
(382) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!GA. A!A. 3
(383) 9
(384)
(385)
(386)
(387)
(388) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!GG. A!I.
(389) 6A-
(390)
(391) 9
(392)
(393) < !!!!!!!!!!!!!!!!!!!!!!!GH. A!G 6
(394) 9
(395)
(396)
(397) 9
(398)
(399) < !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!H. 1
(400) ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,65 .
(401) ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,/2 . !,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,/* !. ''
(402) !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J/ . !
(403) , !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J0 !
(404) 7' !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!J0 .
(405) /
(406)
(407) . * *,*. +
(408) #
(409)
(410)
(411) . 7 '
(412) 9
(413)
(414)
(415) 9
(416)
(417) (
(418) 99
(419) '
(420) *D K+ /5- '
(421)
(422)
(423) /50!
(424)
(425) 9
(426)
(427)
(428) AL5
(429)
(430)
(431)
(432) !
(433)
(434)
(435) *D 9K +5 9
(436)
(437)
(438)
(439) -! 7
(440)
(441)
(442)
(443)
(444)
(445) 9
(446) *E6+5
(447)
(448) )#-M *
(449) -+
(450) 9
(451)
(452) J/-! . *,*
(453)
(454)
(455)
(456)
(457)
(458)
(459)
(460) #
(461) ) ,
(462)
(463) 9
(464)
(465) 9
(466)
(467) *6+
(468)
(469) !5 N25 %
(470) N )&5
(471) 9 N 65
(472) 9
(473)
(474) N
(475) 65
(476)
(477)
(478) 9
(479)
(480) N 8 25 ' %
(481) N 25 %
(482) N9
(483) F %1 OF 5-..JP0/Q!. / .
(484)
(485)
(486)
(487)
(488) ' ' ' *R/!I 0!I/.A @0+ /0 '
(489) 5
(490)
(491)
(492)
(493)
(494) */ 0+ */!A /+N /A5/I!
(495)
(496) 5
(497) 9
(498)
(499)
(500) 9
(501)
(502) 9 9 /G
(503) 9 /-!
(504) 5
(505)
(506) 9
(507) %
(508) * 2+
(509)
(510) 9
(511) 9
(512)
(513) ' %
(514) *8 2+
(515) *, /!/+ /H! " 9
(516) ( 5 9
(517)
(518) '
(519) 59
(520) ' 9
(521)
(522) 5
(523) 9
(524)
(525) *
(526) ' 9
(527)
(528) 9+
(529)
(530)
(531) /L-/! 6)8
(532) ' 9 '
(533) 9
(534) 9
(535)
(536) *, /!-+
(537) /5/-5--5!!
(538) '
(539) -05 9
(540) -A5 8 2-I5-G5
(541) 1 ' /-! . *,- #
(542)
(543)
(544) )
(545)
(546) , 8 '
(547) *9
(548)
(549) +
(550)
(551) (8/..#,
(552)
(553) %
(554)
(555) 7.89
(556)
(557) 9
(558)
(559) *#+578 '
(560)
(561) *;+5 798
(562) 5748' 9
(563)
(564) 8 27%81 ' !7. %86
(565)
(566) 6&37
(567)
(568) 9 #, '
(569) '
(570) #87 @6##,9
(571)
(572) !. - .
(573)
(574)
(575) E9
(576) 5 '
(577) 5
(578) '
(579) *#+ B
(580)
(581)
(582)
(583)
(584) B *;+
(585) 9
(586) !1
(587)
(588)
(589) 9
(590)
(591) 9
(592) 9
(593) 9
(594)
(595) 9
(596) '
(597) # '
(598)
(599) ;!
(600)
(601) 9
(602) ' 9
(603)
(604)
(605)
(606) 9
(607)
(608)
(609)
(610) * 9 /!-!/+ -H! 7
(611) 9
(612)
(613)
(614) 9
(615)
(616) 9
(617) #
(618) % 9 5
(619)
(620) 99
(621) -L!
(622) 5 '
(623)
(624)
(625) ;
(626) 9
(627)
(628)
(629) 9 9
(630) '
(631)
(632) /G! E
(633) 5
(634) % ' 9
(635)
(636)
(637)
(638) 9
(639)
(640)
(641) 5 6)8
(642) 5
(643) ! ; 5 ? 9
(644)
(645) 9
(646) # 9 !! 8/..S 9
(647) 5
(648)
(649) 9
(650) 9 9
(651) 5 9 '
(652)
(653) * 7' //+5 !! ' 9 ' 9
(654) *11+
(655) ( ' 9
(656) *#,+5 ! 6
(657)
(658)
(659) (
(660) ' 9 5
(661)
(662) < 5
(663)
(664)
(665) 5'
(666) 9
(667)
(668)
(669) -G5-J0-*9 /!0!-+!:
(670) 5
(671) 0..
(672) ' %
(673) 9 '
(674) -J5000I5
(675)
(676)
(677) 9 ( 9
(678)
(679) '
(680) '
(681) ' *9/!-+5
(682) 9
(683)
(684)
(685)
(686) *9/!0+! 0 .
(687)
(688)
(689) ( )* *
(690)
(691)
(692) .
(693) /5 . 4* * '/ ; . ) 7 <8 9
(694)
(695) 79<8. 9 ' 59
(696) &6
(697) 9
(698) 5 . 9! 02=30 79!02=9!308. #9<
(699) N
(700) @ E
(701)
(702) <
(703) . ) 7 .<8. . .(>%..(*. # @9 9
(704) . ( *>%..(-. # 9
(705) .
(706)
(707) 78. # '
(708) . ?
(709) . .
(710) ' T9
(711) 59
(712) < . 6-M' 9
(713) . & . . 0050G50H. . 0L. . 0JA/. . A-5A0. 8
(714) '
(715) . .
(716) 560. 9/A5 ;T#
(717) N60.@A0 9
(718)
(719) %
(720) 3
(721) 5 5
(722) 58 2
(723) 5 9 ' 5)86
(724) ' 5 5 9
(725) 5
(726) ' T9
(727)
(728) ' 59
(729) T 3
(730) ' 5
(731) 3 5
(732)
(733) ' 59
(734) T N9 3
(735) ' 5
(736) . 6
(737) ( 9
(738) ' . *22@. 1
(739) .
(740) ' 9
(741) 5
(742) %
(743) @ 3 5
(744) 9 ' T9
(745) 5
(746) . .: 37.;<38. 19-. %!
(747)
(748) . AAAG. . AHI/. . I-IH. . I05IA5IL. . IJG/. . -/. . A.5G-. . G0GG. . -/. . *,-. .
(749)
(750) )
(751) .
(752)
(753)
(754) 9
(755)
(756) 9
(757) ' '
(758) GH. 5 9:
(759)
(760) 5
(761)
(762)
(763) . GL5GJ. 5
(764) 9
(765) . H.. .
(766)
(767)
(768) 9 9
(769) ' H/H0*
(770) 9 , /!0+! . A .
(771)
(772)
(773) . HA. *,07.8+
(774)
(775)
(776) ) A9
(777) 8
(778)
(779) !78 7 9 9
(780)
(781)
(782) 9
(783)
(784) 9 9 99
(785) 9
(786) 5 HI
(787) *9 +
(788) 9
(789) N9
(790) 9 ! !. 7
(791) 9
(792) D 9 9K *, /!0 1+ 9 9
(793) 9 9 '
(794) 5 9
(795)
(796)
(797)
(798) 9
(799) 9 '
(800)
(801) /A5HG5HH!
(802) 9 9
(803)
(804) 9
(805) *!!#875#7/+ *#8+ 9( %
(806)
(807)
(808)
(809)
(810) . G/. ! 7 9 9
(811) .
(812)
(813)
(814) '
(815)
(816)
(817) 5
(818) IA5HL5HJ! &
(819) *)M+5 *6-M+ 9
(820) *FM+
(821) 9
(822) '!! F A!/ L.. !)
(823) ' 5
(824)
(825)
(826) *9/!-!/N, /!A+
(827) . '
(828)
(829)
(830) 9
(831) '
(832)
(833) ' ' *111+ 05HA5L/5L-. 5
(834)
(835)
(836) 9 9
(837) L05LA!. . I .
(838)
(839)
(840) /!-!/ #
(841) '
(842)
(843) ' ' 7
(844) *9 , /!A!+
(845) 9
(846)
(847)
(848) '
(849)
(850) 5 9
(851)
(852)
(853) 9 ! 9 =
(854) 3
(855) ' 9> 9 ' ' '*1+
(856) < 9 *
(857) 9 +' LIJ.! 7
(858) 9 ' ' ' 9 '
(859)
(860)
(861)
(862)
(863)
(864) 1 J/J0!)
(865) ' 5
(866)
(867)
(868) 1
(869) 5!!'
(870) 9
(871)
(872) S/ 5
(873) 9
(874)
(875) JA 9
(876) 9
(877) < JI5JG! . *,3 #
(878) ) ) ) ,7.86
(879)
(880)
(881)
(882) ' '
(883)
(884) /A ' ' N9
(885) ) ! !78
(886)
(887) N6 9 NU JH 9 N8 9 9N&
(888) N9
(889) 1 ! !7988 9
(890)
(891)
(892) 9
(893) ' '
(894)
(895) ' ' ''*1N
(896) +<
(897)
(898) 5
(899) 1* + 9 9 *
(900)
(901) 3
(902) ' 9+! 7
(903)
(904)
(905) *
(906)
(907) ' ( +
(908)
(909) *' (
(910) 1+
(911) < 9 LI *
(912)
(913)
(914) 9 +N
(915)
(916)
(917) ! !.
(918)
(919)
(920) 5
(921)
(922)
(923)
(924) 9
(925) ' '
(926)
(927) B 5 5 9 -HB
(928)
(929)
(930)
(931)
(932) '
(933)
(934)
(935) *9
(936) =9
(937) >+/-5JL! G .
(938)
(939)
(940) :
(941) 5
(942)
(943) 99
(944)
(945) '
(946)
(947) ' ' '9
(948) 9
(949) 9
(950) '
(951)
(952) ' !7 '
(953)
(954) ' ' *111+ 9
(955)
(956)
(957)
(958) 9
(959)
(960)
(961)
(962) ' '
(963)
(964)
(965) ' 9 % 9
(966) 9LG5JJ! ; ' '
(967)
(968) ' <
(969) 5
(970) 9
(971)
(972) ' ' 9
(973)
(974) ?9
(975) *!! ?9AN7' //+ /..!
(976)
(977) 5
(978)
(979)
(980) ' '
(981)
(982)
(983) ' /./5
(984)
(985) *)E+5
(986) /.-/.A! 7 5
(987) ('
(988) 59
(989) 9
(990)
(991)
(992) 95
(993)
(994) 111 J.5/.I5/.G5 6)8 9
(995)
(996)
(997) 111
(998) /.H//-! *,0. .
(999)
(1000)
(1001) .
(1002)
(1003) 6)89
(1004)
(1005) ' < //0//L5
(1006) ( //J/-/. 5 '
(1007) . /--/-A. 5 9 9 . LA5/-I/-L. 5
(1008) .
(1009)
(1010) ( % > . /-J/0/. 9
(1011) . /0-/0A. 5 (
(1012) > . /0I.
(1013) .
(1014)
(1015) 9
(1016) *8+ /0G5/0H! 6)8 9
(1017)
(1018) 111
(1019) 9
(1020)
(1021) (
(1022)
(1023)
(1024)
(1025)
(1026)
(1027)
(1028)
(1029)
(1030) '
(1031)
(1032) E6
(1033) =
(1034) > /0L /A.. ! 3
(1035)
(1036) '
(1037) 5
(1038) 9
(1039)
(1040)
(1041) .
(1042)
(1043) 9
(1044)
ÄHNLICHE DOKUMENTE
The effects of the nitric oxide synthase inhibitor 7-nitroindazole on ethanol pharmacokinetics in rats after acute and chronic ethanol administration.. Nitric oxide synthase
Risk factors for 1-year major adverse kidney events included lower GFR at baseline, higher AKI stage at ECMO cannulation, and number of red blood cell trans- fusions. Therefore,
Untreated prior pulmonary tuberculosis adversely affects pregnancy outcomes in infertile women undergoing in vitro fertilization and embryo transfer: a large retro- spective
Here, we report the potential use of hybrid lecithin/chitosan nanoparticles designed and already studied for nose-to-brain administration [14] in the dampen- ing of psychosine and
The mean findings of our study were: 1) In addition to good prediction for moderate and se- vere AKI, as showed in the validation study, we found that any AKI (including and
In cultured human microvascular endothelial cells, LiCl as well as SB 216763, another small molecule that activates Wnt/b-catenin signaling, induced proliferation, survival
Consequently, there is an urgent need for liver models that allow to screen drug candidates for their potential to induce idiosyncratic DILI in the early non- clinical
The most commonly used definition in stud- ies researching neonatal AKI is the one recommended by the Kidney Disease Improving Global Outcomes (KDIGO), which uses serum creatinine
