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Supplementary Material

Figure S1. Funnel plot for the selected studies is symmetrical, which indicates low risk of publication bias.

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Figure S2. Forest plot for changes in CD4 cell count from baseline to Week 48

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Figure S3. Forest plot for adverse events from baseline to week 48

3a. Forest plot for all AEs recorded (including non-treatment-related AE)

3b. Forest plot for all grade 3 or grade 4 AEs occurring during the treatment period (including non-treatment-related AE)

3c Forest plot for treatment-related AE

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Figure S4. Forest plot for weight change from baseline to week 48 for 4030 study and week 144 for 1489 and 1490 studies

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