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Light-induced Free Radical Oxidation of 2-Oxo-1,2,3,4-tetrahydropyrimidines

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Light-induced Free Radical Oxidation of 2-Oxo-1,2,3,4-tetrahydropyrimidines

Hamid Reza Memariana, Leila Hejazia, and Asadallah Farhadib

aCatalysis Division, Department of Chemistry, Faculty of Science, University of Isfahan, 81746-73441 Isfahan, I. R. Iran

bFaculty of Petroleum Engineering, Petroleum University of Technology of Ahwaz, Ahwaz, I. R. Iran

Reprint requests to Prof. Hamid R. Memarian. Fax: +98-311-6689732.

E-mail: memarian@sci.ui.ac.ir

Z. Naturforsch.2012,67b,263 – 268; received January 15, 2012

A variety of 4-substituted 5-acetyl- and 5-carboethoxy-2-oxo-1,2,3,4-tetrahydropyrimidines were oxidized under UV irradiation in the presence or absence of benzoyl peroxide. The nature of the substituents on the 4- and 5-positions of the heterocyclic ring affects the rate of photo-oxidation, and irradiation of these compounds in the presence of benzoyl peroxide decreases the time of reaction drastically. Removal of 4-H by a benzoyloxy radical under formation of a trihydropyrimidinoyl radi- cal intermediate occurs in the rate-determining step. The stability of this benzylic and allylic radical intermediate is affected by the nature and the position of the additional substituent on the phenyl group located at C-4.

Key words:Benzoyl Peroxide, Dihydropyrimidinones, Photo-oxidation, Substituent Effects, Tetrahydropyrimidinones

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