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Synthesis and Properties of Selected 4-Substituted Anhydro Sugars Raid J. Abdel-Jalil

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Synthesis and Properties of Selected 4-Substituted Anhydro Sugars

Raid J. Abdel-Jalil

a

, Muhammad Saeed

a

, Peter Heeg

b

, and Wolfgang Voelter

a,

*

a Abteilung für Physikalische Biochemie des Physiologisch-chemischen Instituts der Universität Tübingen, Hoppe-Seyler-Strasse 4, D-72076 Tübingen, Germany

b Universitäts-Kliniken-Klinikhygiene, Calwer Strasse 7, D-72076 Tübingen, Germany

* Reprint request to Prof. Dr. Dr. h. c. Wolfgang Voelter.

E-mail: wolfgang.voelter@uni-tuebingen.de

Z. Naturforsch.55 b,661Ð666 (2000); received February 15, 2000 Anhydro Sugars, Piperazine Derivatives

A new class of 4-deoxy-4-([4-substituted-1-piperazinyl], [4-morpholinyl] and [4-(perhydro- 1,4-thiazin-4-yl)])-2,3-anhydrolyxopyranosides (3aÐgand 6aÐg) were synthesized from ep- oxy triflate moities 2 and 5and 4-substituted piperazines, morpholines and perhydro-1,4- thiazines, respectively, to test their antibacterial activity. The characterized series of new compounds was tested in vitro against E. coli ATCC11229, S. aureus ATCC6538 and C.

albicansSATCC10231.

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