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Anachelin, the Siderophore of the Cyanobacterium Anabaena cylindrica CCAP 1403/2A#

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Anachelin, the Siderophore of the Cyanobacterium Anabaena cylindrica CCAP 1403/2A

#

Hans Beiderbeck

a

, Kambiz Taraz

a

, Herbert Budzikiewicz

a,

* and Anthony E. Walsby

b

a Institut für Organische Chemie der Universität zu Köln, Greinstr. 4, D-50939 Köln, Germany. Fax +49-2 21-4 70-50 57. E-mail: h.budzikiewicz@uni-koeln.de

b School ofBiological Sciences, University ofBristol, Woodland Road, Bristol BS8 IUG, UK. E-mail a.e.walsby@bristol.ac.uk

* Author for correspondence and reprint requests

Z. Naturforsch. 55c,681Ð687 (2000); received May 8, 2000 Anabaena cylindrica, Anachelin, Siderophore

A catecholate siderophoreÐanachelinÐhas been isolated from the cyanobacteriumAna- baena cylindricaCCAP 1403/2A. The central part ofthe siderophore is a tripeptide consisting of l-Thr, d-Ser and l-Ser. Its C-terminus is linked amidically to a 1,1-dimethyl-3-amino- 1,2,3,4-tetrahydro-7,8-dihydroxyquinolinium system and its N-terminus to 6-amino-3,5,7-tri- hydroxyheptanoic acid. The 7-hydroxyl group ofthe latter is esterified with salicylic acid whose carboxyl group is condensed with the 6-amino group to an oxazoline ring. Anachelin is the first genuine siderophore of a cyanobacterium whose structure has been elucidated.

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