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Cancer Immunology, Immunotherapy (2021) 70:2639–2640 https://doi.org/10.1007/s00262-021-02903-w
CORRECTION
Correction to: Transcriptome of CD8 + tumor‑infiltrating T cells: a link between diabetes and colorectal cancer
Reem Saleh
1· Varun Sasidharan Nair
1· Khaled Murshed
2· Mohamed Abu Nada
3· Eyad Elkord
4· Ranad Shaheen
5Published online: 12 March 2021
© Springer-Verlag GmbH Germany, part of Springer Nature 2021
Correction to: Cancer Immunology, Immunotherapy https ://doi.org/10.1007/s0026 2-021-02879 -7
The original version of this article unfortunately contained a mistake. The gene names on Fig. 3C in the proofs were missing.
The corrected Fig. 3 is given in the following page.
The original article has been corrected.
Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The original article can be found online at https ://doi.org/10.1007/
s0026 2-021-02879 -7.
* Eyad Elkord
e.elkord@salford.ac.uk
* Ranad Shaheen
ranad_shaheen@hotmail.com
1 Cancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha, Qatar
2 Department of Pathology, Hamad Medical Corporation, Doha, Qatar
3 Department of Surgery, Hamad Medical Corporation, Doha, Qatar
4 Biomedical Research Center, School of Environment and Life Sciences, Engineering and Environment, University of Salford, Manchester M5 4WT, UK
5 Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), P.O. Box: 34110, Doha, Qatar
2640 Cancer Immunology, Immunotherapy (2021) 70:2639–2640
1 3
A
C
ND D
PTGS2 UGT1A8 UGT1A7 UGT1A9 ADH1C
LEPR FL
T1 EGF AMPD1 ERBB4 PPARGC1A COL11A1 HDAC9 PGR PPARG IL12B CD36 KDR
RXRA MGMT GSTP1 CYBA BID -101
B
Metabolic Immune
Cancer
Colorectal Cancer Metabolic &
Cancer
& immune Diabetes
Metabolic &
Cancer
Disease Class
Esophageal Adenocarcinoma Chemdependency
Pharmacogenomics Metabolic Cardiovascular
Cancer Immune Infection Hematological Renal Developmental Aging Reproduction
Vision
Percentage20 0
Disease
Percentage Type 2 Diabetes
Chronic Renal Failure Acquired Immunodeficiency Hypertension Myocardial Infarction Coronary Artery Disease Asthma Colorectal Cancer
Obesity Heart Failure Psychiatric Disorders Hyperparathyroisism
10 0
GO-term Description FDR
GO:0070887 Cellular response to
chemical stimulus 1.01e-08
GO:0051552 Flavone metabolic process 1.05e-07 GO:0006629 Lipid metabolic process 3.76e-07 GO:0006109 Regulation of carbohydrate
metabolic process 1.99e-06
GO:0031323 Regulation of cellular
metabolic process 2.93e-06
GO:0030334 Regulation of cell migration 5.22e-06 GO:1904224 Negative regulation of
glucuronosyltransferase activity
1.03e-05
GO:0071345 Cellular response to
cytokine stimulus 0.0039
Number of nodes: 23 Number of edges: 40 Average node degree: 3.48 Expected number of edges: 9 PPI enrichment p-value:
2.84E-14
D
Fig. 3 Functional gene enrichment analysis of differentially expressed genes in CD8+ TILs in CRC diabetic versus nondiabetic patients. Dif- ferentially expressed genes (up/downregulated) between CRC dia- betic and nondiabetic patients were imported into DAVID platform for functional annotations. Bar plots for gene annotations based on GAD disease class and disease terms a. Venn diagrams for the sig- nificantly upregulated and downregulated genes in CD8+ TILs from
CRC diabetic patients shared within different disease classes and terms b. Heatmap of Z-score for 23 down/upregulated genes, shared within the “Colorectal cancer”, and “Diabetes” disease terms, in CRC patients with diabetes c. Protein–protein interaction (PPI) network analysis of the 23 genes shared within “Colorectal cancer” and “Dia- betes” disease terms, along with the Gene Ontology terms for each gene d
