RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study.

RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study.

Remo Melchio¹, Jacopo D. Giamello¹, Elisa Testa¹, Luis Alberto Ruiz Iturriaga², Andrea Falcetta¹, Cristina Serraino¹,Piero Riva³, Christian Bracco¹, Leyre Serrano Fernandez², Salvatore D’Agnano¹, Stefano Leccardi¹, Massimo Porta³, Luigi M. Fenoglio¹

Supplemental Material

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Cox Multivariable Models for Prediction of 18-month Mortality in Derivation Cohort, after excluding nursing home residents from analysis (n =241)

Variable Beta HR 95%CI p value

Model 1

Age (every 1 year) 0.04 1.04 1.01-1.07 0.005

Heart Failure (yes/no) 0.63 1.88 1.12-3.18 0.01

Liver disease (yes/no) 1.64 5.18 1.97-13.6 0.001

Altered mental status (yes/no) 1.01 2.72 1.63-4.61 0.000

RDW (%) 0.15 1.16 1.03-1.30 0.01

Model 2

Charlson Comorbity Index

(every 1 point) 0.20 1.22 1.10-1.36 0.000

Altered mental status (yes/no) 1.14 3.14 1.90-5.21 0.000

RDW (%) 0.16 1.18 1.05-1.32 0.003

Model 3

PSI Class (every 1 class, I to V) 0.71 2.04 1.50-2.77 0.000

RDW (%) 0.14 1.15 1.02-1.28 0.01

Temperature (°C) -0.26 0.77 0.62-0.96 0.01

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Figure S1

Flow diagram of participants in the derivation cohort (A) and in the validation cohort (B).

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Figure S2

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Performance (c-statistic) of the scores with and without RDW. A) Derivation cohort; b) Validation cohort.

Dashed line: AUC of score without RDW; Continuous line: AUC of final score (with RDW).

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