1. Auflage 2013. Buch. xv, 300 S. Hardcover ISBN 978 3 7091 1311 0
Format (B x L): 15,5 x 23,5 cm Gewicht: 665 g
Weitere Fachgebiete > Chemie, Biowissenschaften, Agrarwissenschaften >
Pharmazie > Pharmazeutische Chemie Zu Leseprobe
schnell und portofrei erhältlich bei
Die Online-Fachbuchhandlung beck-shop.de ist spezialisiert auf Fachbücher, insbesondere Recht, Steuern und Wirtschaft.
Im Sortiment finden Sie alle Medien (Bücher, Zeitschriften, CDs, eBooks, etc.) aller Verlage. Ergänzt wird das Programm durch Services wie Neuerscheinungsdienst oder Zusammenstellungen von Büchern zu Sonderpreisen. Der Shop führt mehr
als 8 Millionen Produkte.
1 Introduction . . . 1
2 Aflatoxins . . . 3
2.1 Biological Properties . . . 7
2.2 Total Syntheses of Aflatoxins . . . 8
2.2.1 Total Syntheses of Racemic Aflatoxins . . . 8
2.2.2 Enantioselective Total Syntheses of Aflatoxins . . . 11
2.3 Syntheses of Aflatoxin Building Blocks . . . 13
2.3.1 Syntheses of Building Blocks for Aflatoxins B2and G2 . . . 13
2.3.2 Syntheses of Building Blocks for Aflatoxins B1and G1 . . . 15
2.3.3 Synthesis of a Building Block for Aflatoxin M2 . . . 16
2.3.4 Enantioselective Syntheses of Aflatoxin Building Blocks . . . 17
2.4 Syntheses of Biosynthetic Aflatoxin Precursors . . . 18
3 Citrinin . . . 23
3.1 General . . . 23
3.2 Total Syntheses of Citrinin . . . 24
4 Ergot Alkaloids . . . 27
4.1 Structural Subclasses of Ergot Alkaloids . . . 28
4.1.1 Tricyclic Precursors of Ergot Alkaloids . . . 28
4.1.2 Clavine-Type Alkaloids . . . 29
4.1.3 Ergoamides . . . 31
4.1.4 Ergopeptines . . . 31
4.1.5 Related Structures . . . 33
4.2 Biological Properties . . . 34
4.3 Total Syntheses . . . 35
v
4.3.7 Biomimetic Three-Step Synthesis of Clavicipitic Acids . . . 46
5 Fumonisins . . . 49
5.1 Biological Properties . . . 51
5.2 Total Syntheses . . . 51
5.2.1 Total Synthesis of Fumonisin B1 . . . 51
5.2.2 Enantioselective Total Synthesis of Fumonisin B2 . . . 54
5.2.3 Total Synthesis of AAL-toxin TA1 . . . 57
6 Ochratoxins . . . 61
6.1 Biological Properties . . . 62
6.2 Total Syntheses . . . 63
6.2.1 Enantioselective Total Synthesis of (R)-Ochratoxin aand Ochratoxins A, B, and C . . . 63
6.2.2 Total Syntheses of Racemic Ochratoxinsaand Ochratoxins A, B, and C . . . 64
6.2.3 Total Syntheses of All Stereoisomers of Ochratoxin A . . . 66
7 Patulin . . . 69
7.1 General . . . 69
7.2 Total Syntheses of Patulin . . . 70
8 Trichothecenes . . . 73
8.1 Biological Properties . . . 76
8.2 Total Syntheses . . . 76
8.2.1 Non-Macrocyclic Trichothecenes . . . 76
8.2.2 Macrocyclic Trichothecenes . . . 83
9 Resorcylic Acid Lactones . . . 91
9.1 Biological Properties . . . 92
9.2 Total Syntheses . . . 93
9.2.1 Total Syntheses of Zearalenone . . . 94
9.2.2 Total Synthesis of Zearalenol . . . 98
9.2.3 Total Synthesis of Radicicol . . . 100
9.2.4 Total Synthesis of Hypothemycin . . . 102
9.2.5 Total Synthesis of Aigialomycin D . . . 104
9.2.6 Total Synthesis of Pochonin C . . . 107
10 (Thio)diketopiperazines . . . 109
10.1 Biological Properties . . . 111
10.2 Total Syntheses . . . 112
10.2.1 DKP Total Syntheses . . . 112
10.2.2 TDKP Total Syntheses . . . 118
11 AlternariaMetabolites . . . 127
11.1 Biological Properties . . . 129
11.2 Total Syntheses . . . 131
11.2.1 Total Synthesis of Alternariol and Alternariol 9-Methyl Ether . . . 131
11.2.2 Total Synthesis of Altenuene and Isoaltenuene . . . 133
11.2.3 Total Synthesis of Dehydroaltenusin . . . 134
11.2.4 Total Synthesis of Neoaltenuene . . . 136
11.2.5 Total Synthesis of Tenuazonic Acid . . . 137
12 Skyrins . . . 139
12.1 Biological Properties . . . 143
12.2 Syntheses of Skyrin Model Systems . . . 145
12.3 Total Syntheses of Skyrins . . . 149
13 Xanthones . . . 153
13.1 Xanthones . . . 155
13.1.1 Bikaverin . . . 155
13.1.2 Pinselin and Pinselic Acid . . . 155
13.1.3 Sterigmatocystin and Derivatives . . . 156
13.1.4 Nidulalin A . . . 164
13.2 Tetrahydroxanthones . . . 166
13.2.1 Blennolides . . . 166
13.2.2 Dihydroglobosuxanthone . . . 172
13.2.3 Diversonol . . . 173
13.2.4 Diversonolic Esters . . . 179
13.3 Hexahydroxanthones . . . 180
13.3.1 Applanatins . . . 180
13.3.2 Isocochlioquinones . . . 181
13.3.3 Monodictysins . . . 182
13.4 Xanthone Dimers and Heterodimers . . . 183
13.4.1 Acremoxanthones . . . 183
13.4.2 Vinaxanthones . . . 184
13.4.3 Xanthofulvin . . . 187
13.5.12 Sch 54445 . . . 204
13.5.13 Xanthonol . . . 205
14 Cytochalasans . . . 207
14.1 Biological Properties . . . 210
14.2 Total Syntheses . . . 213
14.2.1 Total Synthesis of Cytochalasin B and L-696,474 . . . 213
14.2.2 Total Synthesis of Proxiphomin . . . 216
14.2.3 Total Synthesis of Cytochalasin H . . . 217
14.2.4 Total Synthesis of Cytochalasin G . . . 218
14.2.5 Total Synthesis of Cytochalasins D and O . . . 219
14.2.6 Total Synthesis of ( )-Aspochalasin B . . . 220
14.2.7 Total Synthesis of Zygosporin E . . . 222
15 Peptidic Mycotoxins . . . 225
15.1 Biological Properties . . . 226
15.2 Total Syntheses . . . 228
15.2.1 Total Synthesis of Pithomycolide . . . 228
15.2.2 Total Synthesis of Ustiloxins D and F . . . 228
15.2.3 Total Synthesis of Malformin C . . . 229
15.2.4 Total Synthesis of Unguisin A . . . 231
Abbreviations . . . 233
References . . . 237
Author Index . . . 273
Subject Index . . . 295
Listed in PubMed
