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NOT FOR QUOTATION WITHOUT PERMISSION OF THE AUTHOR

ON THE NOTION OF RANDOM

INTENSITY

k1. Yashin

March 1985 WP-85-013

Working Papers a r e interi.m reports on work of t h e International Institute for Applied Systems Analysis and have received only limited review, Views or opinions expressed h e r e i n do not necessarily r e p r e s e n t those of t h e Institute or of its National Member Organizations.

INTERNATIONAL INSTITUTE FOR APPLIED SYSTEMS ANALYSIS 2361 Laxenburg, Austria

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O N THE NOTION O F RANDOM

INTENSITY

A.1. Yashin

DUCTI ION

The

problems of explaining t h e observed t r e n d s in mortality, morbidity a n d o t h e r kinds of individuals' transitions generated t h e numerous attempts of incorporating t h e covariates into t h e survival models. First models use t h e deterministic c o n s t a n t fac- t o r s as explanatory variables

[I,

2,3]. Gradually i t became clear t h a t t h e random a n d dynamic n a t u r e of t h e covariates should also be taken i n t o account [4,5,6]. This understanding h a s led t o t h e fact t h a t t h e notion of random intensity became widely used in t h e analysis of t h e asymptotic properties of t h e maximum likelihood a n d Cox- regression estimators [ 7 , 8 ] .

Having t h e clear intuitive sense t h e notion of random intensity can be introduced in different ways. The traditional way is to define t h e intensity in t e r m s of probability distributions of t h e failure time [9, 10. 111. Another way appeals t o t h e martingale theory [12] a n d defines t h e intensity in t e r m s of t h e predictable process, called

(3)

"compensator" [13, 141. For t h e deterministic r a t e s a n d simple cases of stochastic intensities t h e r e a r e already results t h a t establish a one-to-one correspondence between two definitions. The correspondence is r e a c h e d by t h e probabilistic represen- tation results for compensator [13,14]. Martingale theory guarantees t h e existence of t h e predictable compensator in more general cases. However t h e results on t h e proba- bilistic representation similar t o simple cases a r e still unknown. Meanwhile such representation is crucial, for instance, in t h e analysis of t h e relations between the duration of t h e life cycle of some unit and stochastically changing influential vari- ables. This paper shows t h e result of such representation for some particular case.

The generalization on t h e more general situations i s straightforward. The considera- tion will use some basic notions of a "general theory of processes" [12, 151.

-

Let T be t h e stopping time defined on some probability space ( R . H , H , P ) , where H

=

(Ht)t,o is t h e right-continuous nondecreasing family of o-algebras in R, such t h a t

H , =

H and Ho is completed by P-zero sets from

H.

If distribution of T is absolutely continuous t h e traditional definition of t h e intensity X ( t ) , related to t h e stopping time

T is a s follows

Martingale characterization defines the r a t e in terms of the process A ( t ) which is supposed to be H-predictable and such t h a t t h e process M ( t ) defined as

is an H-adapted martingale. It t u r n s out t h a t for process M ( t ) to be martingale, ~ ( t ) should have t h e form

(4)

where

A ( u )

is given by (1). The family H in this case is generated by t h e indicator pro- cess

4 = I ( t

2

T ) .

If t h e stopping time T is correlated with some random variable

z ( o ) ,

t h e n t h e traditional approach defines t h e intensity in terms of conditional pro- babilities

Martingale characterization shows t h a t the process

M z ( t )

is a martingale with respect t o t h e family of o-algebras

HZ.

generated in

R

by t h e indi- cator process

I ( t r T )

a n d random variable

z .

In the case of a discontinuous condi- tional distribution function for T, formula

( 2 )

should be corrected. The notion of cumulated intensity

h ( t , z )

is more appropriate in this case. The formula for it is

and martingale characterization is respectively [13,14]:

The situation is not so clear however if one has t h e random processes, say Yt, correlated with stopping time

T .

Assume for instance t h a t Yt simulates t h e changes of t h e physiological variables of some patient i n hospital a n d

T

is the time of death. It is clear t h a t in this case t h e process

3

should terminate a t time T, so observing Yt one can tell about t h e alive/dead s t a t e of the patient, t h a t is, can observe t h e death time.

(5)

I t

is clear also t h a t t h e s t a t e or t h e whole history of t h e physiological variable influences t h e chances of occurring death. The question is how can one specify t h e random intensity in terms of conditional probabilities in order to establish t h e correspondence between intuitive traditional and martingale definitions of t h e random intensities.

The idea t o use

h ( t

,

Y )

in t h e form

where a-algebra

q

is generated in

R

by t h e process Y,, up to time

t

fails because

q

contains t h e event

1 T I t

j. Taking

q-

instead of

HfV

seems t o improve t h e situation, however t h e event

fT

2

t 1

is measurable with respect to

q-.

So t o find t h e proper formula for random intensity one needs t o get t h e probabilis- t i c representation result for HY-predictable compensator.

RESULT

HO-TION

We will demonstrate t h e result and t h e ideas of proof on a simple particular case.

The generalization on a more general situation i s straightforward.

Assume t h a t stopping time

~ ( w )

and t h e Wiener process

wt ( w )

a r e defined on some probability space ( R , H , P ) and are independent for any

t

r 0. Define

& =

Wt

- / ( T ~ t ) w ~ .

Let

I P = (q)t90, H = (Hyl)tro

where

q = utY,.u t j

(6)

The following s t a t e m e n t is t r u e .

Theorem

W - p r e d i c t a b l e c o m p e n s a t o r A Y ( t )

of

t h e process I ( T

S

t ) have the fol- lowing r e ~ e s e n t ation

The proof of t h i s theorem will be followed by some auxilliary lemmas.

Let

H;I =

ol&, u

s t 1,

where

4 = I ( T

5

t ).

I t is clear t h a t

= q

v

H;I.

Denote

HI = HZ, = HT.

The n e x t assertion underlines t h e important property of t h e stopping times with respect t o

W .

Lemma 1.

Fbr a n y W stopping t i m e

7

one c a n find t h e r a n d o m v m i u b l e s

S

a n d

S'

s u c h t h t i n d i c a t o r I ( S

r

s )

is

m e a s u r a b l e f o r a n y s

r 0 ;

i n d i c a t a I ( S '

r s ) is

HT m e n s u r a b l e f o r a n y s

r 0

a n d :

Let u s first prove t h e first equality. From t h e definition of i t follows t h a t

G- n

t s zz

T j = t s TI

;

t h e r e f o r e

( V V

H&)

n1.5 T I = q n t s s

TI

o r by virtue of coincidence of t h e s e t s @'

n [ t s TI

a n d

(q

v H f )

n [ t

ZZ

T ]

and con-

tinuity of t h e flow of 8-algebras W :

H'f- n t s s T ] = g ' n 1 ~ 1 T j .

Taking t h e s e t [ r

<

s

I

from II,YY one c a n find t h e s e t

D,

from s u c h t h a t

(7)

- 6 -

~ T < s ] n

1s

s T ] = D s n

1s

s T ] .

Note now t h a t for T

<

s

lo, U D , I n

I S

s T I = D ~ n

1s

T ]

In f a c t

Define t h e random variable S by t h e relations

Where T a n d s a r e r a t i o n a l n u m b e r s we have

which completes t h e proof of t h e first equality. The s e c o n d equality c a n b e proved i n a similar way.

The n e x t lemma deals with t h e r e p r e s e n t a t i o n of IF"-adapted s q u a r e integrable martingales a s s t o c h a s t i c i n t e g r a l s with r e s p e c t t o Wiener p r o c e s s

Wt.

kmma 2. Let

h? = ( M t )t,O

be a W - u d a p t e d s q u u r e i n t e g r a b l e m a r t i n g a l e . Then f h e r e .is an Hw-adapted p r o c e s s f ( s , w ) , s r 0 s u c h

that

f o r m y f

a n d

(8)

The proof of this lemma may be found in [13].

The next s t a t e m e n t will play an important role in t h e characterization of

W -

predictable processes.

lemma

3. Any W - w e l l measurable process is W - p r e d i c t a b l e .

Proof. Let T be t h e a r b i t r a r y stopping time with respect t o

H"'.

Denote by A(t) W - p r e d i c t a b l e compensator of t h e process I ( T

s

t ) . According t o t h e definition of

compensator t h e process Mt

=

I ( T 6 t )

-

A(t) is t h e bounded martingale with r e s p e c t t o

W .

According to Lemma 2 t h e r e exists H"'-adapted function f ( s , o ) s u c h t h a t

By virtue of the continuity of t h e stochastic integral's trajectories, t h e right-hand side of t h i s equality is W - p r e d i c t a b l e . This f a c t yields t h e IT"-predictability of t h e indica- t o r I ( T s t ) for a n y t t h a t in t u r n yields t h e H"'-predictability of t h e stopping time 7.

The predictability property for any stopping time with r e s p e c t t o

W

yields t h e coin- cidence of t h e well-measurable a n d predictable a-algebras.

lemma

4. Hv-adapted process

Z =

(q)t,o is P - p r e d i c f a b l e if and only if there is an W - m e a s u r a b l e process X

=

(4)t,o a n d Hy-well m e a s u m b l e process X'

=

(x;'),,~

s u c h that

h o o f . Necessity. Let Zt

=

I ( t S T) where T is an a r b i t r a r y stopping time with r e s p e c t t o W . According t o t h e r e s u l t of Lemma 1 we have:

(9)

where S is some random variable, such t h a t indicator

I ( t

S S ) is @'-measurable for any

t

2 0. ,Setting

Yt = I ( t

s S ) we get t h e necessity of t h e condition (6) for t h e pro- cess Zt

= I ( t s

7 ) .

Denote by

L

t h e s e t of bounded *-adapted functions which satisfy relation (6). I t is easy t o see t h a t

L

is closed with respect t o monotonic convergence t o bounded func- tions and contains t h e s e t of indicators

I ( t

1 T ) , where T is arbitrary stopping times with respect t o W . This s e t of indicators is t h e algebra; i t contains t h e 1, and gen- e r a t e s t h e @-predictable a-algebra in

R

x

R,.

The necessity of the condition (6) of t h e lemma follows as a result of montone classes theorem [15]. In t h e same way the necessity of condition

( 7 )

can be proved

Sufficiency. Note t h a t for any arbitrary P - a d a p t e d and left continuous process Lt t h e process

I ( t s T)Lt

is @-adapted and left continuous; therefore

where

P ( P )

a n d

P ( @ )

denote El""-predictable and W-predictable a-algebras, respec- tively. According t o Lemma 3 t h e process

Yt

from t h e relation (6) is W-predictable, a n d process

X

from

( 7 )

is Hw-predictable. Consequently t h e processes

4 I ( t

I

T )

and

&I(T

5 f ) a r e @-predictable.

Define t h e process

A ( t )

by t h e equality

The following statement concerns t h e measurability property of

A ( t )

which is impor- t a n t for predictable specification of t h e compensator.

(10)

Lemma 5. ?he process h(t ) is

W

-predictable.

Proof. For h(t ) one can write

The first addendum on t h e right-hand side is an W-predictable process in accordance with Lemma 4. The second is an W-adapted, left-continuous process and consequently i t is also P - p r e d i c t a b l e .

The next lemma demonstrates t h e last effort i n proving t h e main result.

Lemma 6. 7he process

=

I(T s t )

-

A(t ) is

W

-martingale.

Proof. Consider t h e process

It i s clear t h a t

E 1

~ ()

1

t

<

=. Let u s prove t h a t

E ( M ( ~ )

1 =

M(S)

.

We have

The first t e r m can be transformed i n t o

In order to transform t h e second addendum l e t us assume for simplicity t h a t t h e conditional distribution of T is absolutely continuous a n d consequently A(t) can be r e p r e s e n t e d i n t h e form

t

(11)

where h ( w , u ) is FP-adapted process

we have

Taking into account formula ( 9 ) for X ( W . U ) , t h e last addendum can be transformed into t h e form

Subtracting ( 1 0 ) from (8) a n d taking i n t o account ( l l ) , one can s e e t h a t

The uniqueness of W-predictable compensator yields t h e coincidence of A ( t ) a n d A Y ( t ) t h a t completes t h e proof.

Remark. It t u r n s out t h a t even if t h e o-algebra has t h e more general struc- t u r e t h a n in t h e example above, for instance,

=

@ v

p,

t h e r e s u l t of t h e proba- bilistic representation of t h e P - p r e d i c t a b l e compensator of t h e process

(12)

X(t )

=

I ( T

s

t ) given by formula (5) is t r u e .

Example. The relevance of t h e results such as formula (5) becomes evident from the following example. Assume t h a t Wiener process

Wt

and stopping time T a r e inter- related and t h e random intensity of occurrence

T

is h ( t ) ~ f 2 . Formula (5) gives immediately the form of t h e conditional survival function

In survival analysis the stopping time

T

is associated with the death or failure time and the research is often focused on the properties of t h e survival function S ( t )

=

P ( T

> t

) [8,11,10,7]. The straightforward way of its calculation is the averag- ing of the conditional survival function S ( t (

w;).

It t u r n s out t h a t (see for instance

161)

For the Wiener process t h e conditional mathematical expectation on t h e right-hand side of this formula can be easily calculated ( t h e condition

W o =

0 is used there)

where y(t ) is t h e solution of t h e differential equation

+ ( t )

=

1 - 2 h ( t ) ? ( t ) , y(O)=O

.

When A(t) i s constantly equal, say, t o

- 1

the straightforward calculations lead to the 2

formula

(13)

which coincides with t h e r e s u l t based on the Cameron a n d Martin formula 1131.

CONCLUSION

Formula (5) c a n be generalized in more complex c a s e s including t h e sequence of stopping times and semimartingale as an influential stochastic process. I t can be use- ful in t h e field of survival analysis, reliability theory and risk analysis. I t shows which particular conditional distribution functions should be used i n specification of t h e random intensities. The specification of the influential process and t h e measurement schemas provide t h e particular forms for t h e distributions and t h e intensities. Some examples, r e l a t e d to t h e biomedical and demographical applications a r e discussed in [17, 18, 161.

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1.

D.R.

Cox, "Regression Models and Life Tables." Journul of Royal Stat.tisticaL S c i e t y B 34, pp. 107-220 (1972).

2 .

D.R

Cox, "Partial Likelihood," Biomet7-ikaA 62 , pp.269-276 (1975).

3. K. Bailey, "The Asymptotic Joint Distribution of Regression and Survival Parameter Estimates in t h e Cox Regression Model." 7Ae Annals of S a t i s t i c s 11(1), pp.39-48 ( 1983).

4. P.K. Anderson and R. Gill, Cox R e g r e s s i o n Model f o r Counting P r o c e s s e s : A h g e a m p l e ShLdy, Statistical Research Unit, Danish Medical Research Council, Danish Social Science Research Council, Copenhagen (1981). RR- 81-6.

(15)

RD. Gill, "Understanding Cox's Regression Model: A Martingale Approach,"

Jo,umal of American Statistical Association

?9(386), pp.441-447, June 1904 (1984).

RL. Prentice and S.G. Self,

Asymptotic Distribution Theory for Coz-type B g r e s s i o n Models

with

General Relative

&k F b r m , 1983.

D.R Cox and D. Oakes,

Analysis of Survival h t a ,

Chapman and Hall, London (1984).

RC. Elandt-Johnson and N.L. Johnson,

Sunrival Models and Data Analysis,

John Wiley and Sons, New York (1979).

RE. Barlow and

F.

Proschan,

Statistical lheory of Reliability and Life Testing,

Holt, Rinehart and Winston, Inc., New Y ork (1975).

J.F. Lawless,

Statistical Models and Methods for Lifetime Data,

John Wiley and Sons, New York (1982).

W. Nelson,

Applied Life Data Analysis

, John Wiley and Sons, New York (1982).

J. Jacod,

Calcules S o c h a s t i q u e et R o b l e m e

d e

Martingales. Lecture Notes

in

Mathematics, Vol.

714, Springer-Verlag, Heidelberg (1979).

RS. Liptzer a n d AN. Shiryaev,

Statistics of Random Processes,

Springer- Verlag, Berlin a n d New York (1978).

J. Jacod, "Multivariate Point Processes: Predictable Projection, Radon- Nicodim Derivatives, Representation of Martingales,"

Z d t s c h r i f t

fim

Wahrscheidichkeitstheorie u n d

Veur. Gebiete

31. pp.235-253 (1975).

C. Dellacherie,

Capacities e t Processus Sochastiques (Capacities

and

Sto-

chastic Processes),

Springer-Verlag, Berlin and New York (1972).

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16. Al. Yashin, D y n a m i c s in S u r v i v a l Analysis: Conditional Gaussian P r o p e r t y Ve?-sus C a m e r o n - M u r t i n F o r m u l a . WP- 8 4 1 0 7 , lnternational lnstitute for Applied Systems Analysis, Laxenburg, Austria (1984).

17. Al. Yashin, K.G. Manton, and

J.W.

Vaupel, Mortnlity a n d Aging in a Hetero- g e n e o u s PopuLation: A S o c h a s t i c P r o c e s s Model with Observed a n d Unob- s e r v e d Variables. WP-83-81, International lnstitute for Applied Systems Analysis, Laxenburg, Austria (1983).

10. Al. Yashin and K.G. Manton, 5 a l u a t i n g the m f e c t s of O b s e m e d and h o b - s e r v e d D i f f u s i o n P r o c e s s e s in S u u i u a l A d y s i s of Longitudinal Data. CP- 84-58, lnternational lnstitute for Applied Systems Analysis, Laxenburg, Aus- t r i a (1964).

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