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Role of the Hydroxymethyl Group for the Inhibitory Activity of Penienone Yasuo Kimura

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Role of the Hydroxymethyl Group for the Inhibitory Activity of Penienone Yasuo Kimura

a

, Takashi Mizuno

a

, Tsuyoshi Kawano

a

, and Atsumi Shimada*

,b

a Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University, Koyama, Tottori 680Ð8553, Japan

b Department of Environmental Chemistry, Faculty of Engineering, Kyushu Kyoritsu University, Yahatanishi, Kitakyushu 807Ð8585, Japan

* Reprint requests to Dr. A. Shimada.

Fax: (+81) 93Ð693Ð3201;

E-mail: jun@kyukyo-u.ac.jp

Z. Naturforsch.54 b,1342Ð1344 (1999);

received June 7, 1999

Penicilliumsp., Penienone, Growth Inhibitor, Lettuce

Penienone was isolated from the culture filtrate ofPenicilliumsp. No.13 and completely inhibited hypocotyl elongation and root growth of lettuce seedlings at a concentration of 300 mg/l. In order to elucidate the active site of penienone, three de- rivatives were prepared and tested for their inhib- itory activity against the growth of lettuce seed- lings. The results indicated that hydroxymethyl groupin the molecule of penienone was essential to exhibit the remarkable inhibitory activity against the growth of lettuce seedlings.

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