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Antinociceptive Activity of the Natural Piperidine Alkaloid Hydrochlorides from Syphocampylus verticellatus

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Antinociceptive Activity of the Natural Piperidine Alkaloid Hydrochlorides from Syphocampylus verticellatus

Obdulio G. Miguel

a

, Adair R. S. Santos

b

, Joa˜o B. Calixto

b

, Franco Delle Monache

c

and Rosendo A. Yunes

d,

*

a Departamento de Farmacia, Universidade Federal do Parana´, Curitiba, Brazil

b Departamento de Farmacologia, Universidade Federal de Santa Catarina, Rua Ferreira Lima, 82, 88015-420ÐFloriano´polis, SC, Brazil

c Centro Chimica Recettori, CNR, Rome, Italy

d Departamento de Quı´mica, Universidade Federal de Santa Catariana, 88040-900, Floriano´polis, SC, Brazil. Fax: (48) 3 31-97 11. E-mail: ryunes@qmc.ufsc.br

*Author for correspondence and reprint requests

Z. Naturforsch.57 c, 81Ð84 (2002); received August 10/October 12, 2001 Syphocampylus verticellatus, Alkaloids Hydroclorides, Antinociceptive Activity

In addition to 3⬘-methoxyluteolin and mixtures of sterols and triterpenes, the leaves of Syphocampylus Verticellatusyielded two piperidine alkaloid hydrochlorides, one of them has a novel structure. The alkaloids exhibit antinociceptive activity.

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