Supplementary Appendix TABLE OF CONTENTS
Supplementary figure S1. PRISMA flowchart
Supplementary figure S2. Forest plots showing the risk of colchicine discontinuation compared with placebo, according to treatment duration (left) and daily dose (right).
Supplementary figure S3. Forest plots showing the risk of gastrointestinal CRAEs compared with placebo, according to clinical setting.
Supplementary table 1. Main features of included studies (according to clinical setting)
Supplementary Figure S1 – PRISMA Flow Chart
Supplementary Figure S2
Supplementary Figure S3
Supplementary Table 1. Main features of included studies (according to clinical setting)
Year Study name First Author Sample size Disease state (clinical setting) Colchicine dose and duration Colchicine, daily dose (mg) Comparator Follow-up Age, years Male sex, %
CORONARY ARTERY DISEASE
1992 - O'Keefe 197
Prevention of restenosis after
coronary angioplasty
Colchicine, 0.6 mg twice daily
for 6 months 1.2 Placebo 6
months 59 85
2011 - Raju 80
Acute coronary syndrome or
stroke
Colchicine, 1 mg daily, for 1
month 1 Placebo 1 month 57.2 89
2013 - Deftereos 222
Bare metal stent restenosis in diabetic patients
Colchicine, 0.5 mg twice daily,
for 6 months 1 Placebo 6
months 63.6 65
2015 - Deftereos 151
ST-segment elavation myocardial
infarction
Colchicine, 0.5 mg twice daily, plus additional 2 mg loading dose (half dose if <60 kg), for 5
days
0.5 to 1 Placebo 5 days 58 69
2015 - Giannopo
ulos
59 Myocardial damage following
Colchicine, 0.5 mg twice daily (half dose if <60 kg), for 10
0.5 to 1 Placebo 10 days 65.2 69
on-pump coronary artery bypass
grafting
days
2019 COLCO
T Tardif 4676 Myocardial
infarction
Colchicine, 0.5 mg daily, for 19
months 0.5 Placebo
23 months (median)
60.6 81
2020 Colchici
ne-PCI Shah 714
Percutaneous Coronary Intervention
Colchicine, 1.2 mg followed by
0.6 mg 1 hour later 1.8 Placebo 30 days 66.2 93.5
2020 LoDoCo
2 Nidorf 5522 Chronic coronary disease
Colchicine 0.5 mg daily (for a
median of 28.6 months) 0.5 Placebo
28.6 months (median)
65.8 84.7
2020 COPS Tong 795 Acute coronary
syndrome
Colchicine 0.5 mg twice daily for 1 month, then 0.5 mg daily
for 11 months
0.5 Placebo 12
months 60 79.5
PERICARDIAL DISEASES
2005 CORE Imazio 84 Recurrent
pericarditis
Colchicine, 1 mg on first day, followed by 0.5 mg daily (if <70 kg) or 1 mg twice daily followed by 0.5 mg twice daily (if ≥70
kg), for 6 months
0.5 to 1
conventional treatment alone (aspirin)
20 months (mean)
53.5 35
2005 COPE Imazio 120 Acute pericarditis
Colchicine, 1 mg on first day, followed by 0.5 mg daily (if <70 kg) or 1 mg twice daily followed by 0.5 mg twice daily (if ≥70
kg), for 3 months
0.5 to 1
conventional treatment alone (aspirin)
24 months (mean)
56.9 45
2010 COPPS Imazio 360 Post-
pericardiotomy syndrome
Colchicine, 1 mg on first day followed by 0.5 mg daily for 1 month (if <70 kg) or 1 mg twice
daily followed by 0.5 mg twice daily for 1 month (if ≥70 kg), for
0.5 to 1 Placebo 1 month 66 66
1 month
2011 CORP Imazio 120 Recurrent
pericarditis
Colchicine, 1 mg on first day followed by 0.5 mg daily for 1 month (if <70 kg) or 1 mg twice
daily followed by 0.5 mg twice daily for 1 month (if ≥70 kg), for
6 months
0.5 to 1 Placebo 18
months 47.6 53
2013 ICAP Imazio 240 Acute pericarditis
Colchicine, 0.5 mg daily (if <70 kg) or 0.5 mg twice daily (if ≥70
kg) , for 3 months
0.5 to 1 Placebo
22 months (mean)
52.1 60
2014 COPPS-
2 Imazio 360
Post- pericardiotomy
syndrome and postoperative atrial fibrillation
Colchicine, 0.5 mg daily (if <70 kg) or 0.5 mg twice daily (if ≥70
kg) , for 1 month
0.5 to 1 Placebo 3
months 67.5 69
2014 CORP-2 Imazio 240 Recurrent
pericarditis
Colchicine, 0.5 mg daily (if <70 kg) or 0.5 mg twice daily (if ≥70
kg), for 6 months
0.5 to 1 Placebo 18
months 48.7 50
2016 - Liebenber
g 33
Pericardial constriction in
tuberculous pericarditis
Colchicine, 1 mg daily, for 6
weeks 1 Placebo 4
months 31 33
2019 - Sambola 110 Acute pericarditis
Colchicine, 0.5 mg twice daily (if <70 kg) or 1 mg twice daily
(if ≥70 kg), for 3 months
1 to 2
conventional treatment alone (aspirin
or NSAIDs)
24
months 44.4 83.3
ATRIAL FIBRILLATION 2012 - Deftereos 161 Atrial fibrillation
recurrence following pulmonary vein
Colchicine, 0.5 mg twice daily, for 3 months
1 Placebo 3
months
62 71
isolation
2016 END-AF Tabbalat 360
Perioperative atrial fibrillation following cardiac
surgery
Colchicine, 0.5 mg twice daily, plus 2 mg before surgery (half
dose if <70 kg), for 8 days
0.5 to 1 Placebo 8 days
(mean) 60.7 78.9
2017 - Besissow 100
Perioperative atrial fibrillation
following lung resection surgery
Colchicine, 0.6 mg twice daily, plus additional 0.6 mg loading
dose, for 10 days
1.26 Placebo 1 month 68.6 45
HEART FAILURE
2014 - Deftereos 279 Chronic heart failure
Colchicine, 0.5 mg daily (if <60 kg) or 0.5 mg twice daily (if ≥60
kg) , for 6 months
0.5 to 1 Placebo 6
months 66.7 67
