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Anti-Infl ammatory and Cytotoxic Activities of Chichipegenin, Peniocerol, and Macdougallin Isolated from Myrtillocactus geometrizans (Mart. ex Pfeiff.) Con.

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Anti-Infl ammatory and Cytotoxic Activities of Chichipegenin, Peniocerol, and Macdougallin Isolated from Myrtillocactus geometrizans (Mart. ex Pfeiff.) Con.

Juan Rodrigo Salazara,e, Mariano Martínez-Vazqueza,*, Carlos L. Cespedesb, Teresa Ramírez-Apana, Antonio Nieto-Camachoa, Juan Rodríguez-Silverioc,d, and Francisco Flores-Murrietac,d

a Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior, Coyoacán, C. P. 04510, México, D. F., México. Fax: 56162203.

E-mail: marvaz@servidor.unam.mx

b Facultad de Ciencias, Departamento de Ciencias Básicas, Universidad del Bio-Bio, Chillan, Chile

c Escuela Superior de Medicina, Instituto Politécnico Nacional, México, D. F., México

d Instituto Nacional de Enfermedades Respiratorias, México, D. F., México

e Current address: Escuela de Ciencias de la Salud, Universidad del Valle de México, Campus Tlapan, Ciudad de México, México

* Author for correspondence and reprint requests

Z. Naturforsch. 66 c, 24 – 30 (2011); received April 9/September 4, 2010

The oleanane-type triterpene chichipegenin and the sterols peniocerol and macdougallin, isolated from Myrtillocactus geometrizans, showed anti-infl ammatory activities in both the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model and the car- rageenan-induced rat paw edema model. All tested compounds inhibited the TPA-induced edema in a dose-dependent manner, with ED50 values less than or equal to that shown by indomethacin. Among them, peniocerol was the most active compound. However, only peniocerol and macdougallin reduced carrageenan-induced rat paw edema. On the other hand, peniocerol and macdougallin showed cytotoxicity against several human cancer cell lines. These results indicate that compounds isolated from M. geometrizans possess anti- infl ammatory and cytotoxic properties, and the presence of chichipegenin in the aerial parts could justify the medicinal uses attributed to the plant.

Key words: Myrtillocactus geometrizans, Anti-Infl ammatory, Cytotoxicity

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