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An Efficient Procedure for the Synthesis of Polysubstituted Pyrroles in an Ionic Liquid

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An Efficient Procedure for the Synthesis of Polysubstituted Pyrroles in an Ionic Liquid

Yan-Hong He, Gang-Qiang Wang, Ke-Ling Xu, and Zhi Guan

School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China

Reprint requests to Prof. Zhi Guan. Fax: +86 23 68254091. E-mail: guanzhi@swu.edu.cn Z. Naturforsch.2011,66b,191 – 196; received October 9, 2010

The ionic liquid 1-butyl-3-methyl-imidazolium hydrogen sulfate, [bmim]HSO4, was used as a cata- lyst and reaction medium for the pyrrole synthesis, and a wide range of aliphatic, aromatic, heteroaro- matic and carboxylic 1,4-diketones easily underwent condensations with aniline and ethylenediamine to form polysubstituted pyrroles. Sequential decarboxylation/Paal-Knorr pyrrole condensation was observed, which provides a new and facile approach to monoester pyrroles from 1,4-diketo-2,3-di- carboxylic acid esters.

Key words:Ionic Liquid, Paal-Knorr Reaction, Polysubstituted Pyrrole, 1,4-Diketone, Decarboxylation

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