Antihepatotoxic Activity of Phyllanthus atropurpureus Cultivated in Egypt
Taha Sarg, Afaf Abdel Ghani, Rawia Zayed*, and May El-Sayed
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt. E-mail: rawiazayed@hotmail.com
* Author for correspondence and reprint requests
Z. Naturforsch. 66 c, 447 – 452 (2011); received April 27, 2010/June 10, 2011
The genus Phyllanthus (family Euphorbiaceae) is considered one of the important medici- nal and ornamental plants. A phytochemical analysis of the extracts was performed to search for the active ingredient. Results of the investigation of the hepatoprotective activity of Phyllanthus atropurpureus Boj. Hort. Maurit. revealed that the activities of alcoholic extracts of its aerial parts and roots were quite similar to those of silymarin. Both of them improve the parameters of CCl4-induced liver injury including serum aspartate aminotransferase and alanine aminotransferase. Among the extracts tested, the root extract showed maximum activity compared to the aerial parts extract and to silymarin.
Key words: Phyllanthus, Euphorbiaceae, Hepatoprotective Activity